ENSG00000196072

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000441611 ENSG00000196072 HEK293_OSMI2_2hA HEK293_TMG_2hB BLOC1S2 protein_coding protein_coding 35.20656 24.35239 49.25782 2.310413 1.47463 1.01599 10.56277 8.202672 13.37096 1.020784 1.0037064 0.7042579 0.3095583 0.3352667 0.2713333 -0.06393333 0.19092749 0.01733368 FALSE FALSE
MSTRG.4484.5 ENSG00000196072 HEK293_OSMI2_2hA HEK293_TMG_2hB BLOC1S2 protein_coding   35.20656 24.35239 49.25782 2.310413 1.47463 1.01599 22.25084 13.651987 32.73269 1.300224 0.6794779 1.2610054 0.6112125 0.5610333 0.6650667 0.10403333 0.01733368 0.01733368 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196072 E001 0.9911135 0.0127702650 5.826017e-01 7.069337e-01 10 100273280 100273292 13 - 0.248 0.350 0.681
ENSG00000196072 E002 13.2212535 0.0020341719 1.390276e-06 1.119209e-05 10 100273293 100273955 663 - 0.900 1.358 1.653
ENSG00000196072 E003 301.3821787 0.0018137667 2.506521e-07 2.357175e-06 10 100273956 100275018 1063 - 2.415 2.554 0.462
ENSG00000196072 E004 646.9329190 0.0005885140 6.779673e-02 1.397092e-01 10 100275019 100275490 472 - 2.797 2.828 0.103
ENSG00000196072 E005 127.7132589 0.0002862261 1.460770e-01 2.563439e-01 10 100275491 100275493 3 - 2.126 2.088 -0.127
ENSG00000196072 E006 3.0391584 0.2287555296 7.558256e-01 8.410507e-01 10 100280041 100280123 83 - 0.552 0.671 0.524
ENSG00000196072 E007 233.4100479 0.0002107288 1.981545e-01 3.238951e-01 10 100280124 100280228 105 - 2.378 2.356 -0.073
ENSG00000196072 E008 268.4562281 0.0002290641 3.736583e-03 1.240119e-02 10 100280934 100281053 120 - 2.452 2.398 -0.181
ENSG00000196072 E009 3.4405711 0.0046697252 2.177702e-01 3.477168e-01 10 100282906 100282936 31 - 0.553 0.743 0.818
ENSG00000196072 E010 224.2035665 0.0020563145 4.220614e-03 1.375965e-02 10 100286097 100286213 117 - 2.384 2.301 -0.276
ENSG00000196072 E011 9.3133111 0.0018911237 2.386674e-01 3.726015e-01 10 100286214 100286300 87 - 0.953 1.084 0.481
ENSG00000196072 E012 6.9645534 0.0024444661 4.772248e-01 6.158323e-01 10 100286301 100286332 32 - 0.855 0.946 0.344
ENSG00000196072 E013 1.1654561 0.4557447612 2.581807e-01 3.954043e-01 10 100286333 100286378 46 - 0.179 0.484 2.002
ENSG00000196072 E014 121.6588305 0.0017030752 8.200431e-06 5.556320e-05 10 100286605 100286694 90 - 2.148 1.985 -0.546