ENSG00000189337

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361144 ENSG00000189337 HEK293_OSMI2_2hA HEK293_TMG_2hB KAZN protein_coding protein_coding 6.923951 8.478466 7.182893 0.2803437 0.1161631 -0.2389317 2.3579558 1.2923898 4.5976529 0.32464096 0.10593400 1.8228708 0.34017083 0.15023333 0.64063333 0.49040000 2.952606e-09 2.952606e-09 FALSE TRUE
ENST00000376030 ENSG00000189337 HEK293_OSMI2_2hA HEK293_TMG_2hB KAZN protein_coding protein_coding 6.923951 8.478466 7.182893 0.2803437 0.1161631 -0.2389317 0.6346261 0.5959997 1.1086890 0.04858050 0.08420309 0.8844201 0.08887083 0.07006667 0.15423333 0.08416667 1.904882e-03 2.952606e-09 FALSE TRUE
ENST00000400798 ENSG00000189337 HEK293_OSMI2_2hA HEK293_TMG_2hB KAZN protein_coding protein_coding 6.923951 8.478466 7.182893 0.2803437 0.1161631 -0.2389317 3.2766732 6.1180853 0.7753422 0.15388152 0.38884869 -2.9640431 0.47445417 0.72440000 0.10636667 -0.61803333 3.364519e-02 2.952606e-09 FALSE TRUE
ENST00000491547 ENSG00000189337 HEK293_OSMI2_2hA HEK293_TMG_2hB KAZN protein_coding retained_intron 6.923951 8.478466 7.182893 0.2803437 0.1161631 -0.2389317 0.3857185 0.2311340 0.4121622 0.01634336 0.05154639 0.8079624 0.05877500 0.02726667 0.05736667 0.03010000 1.056233e-01 2.952606e-09 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000189337 E001 0.8041237 0.0174896334 7.520793e-01 8.383785e-01 1 13892792 13893756 965 + 0.214 0.300 0.648
ENSG00000189337 E002 0.4782907 0.0221126020 1.035801e-01 1.959504e-01 1 14180435 14180592 158 + 0.000 0.300 11.522
ENSG00000189337 E003 0.0000000       1 14304590 14304663 74 +      
ENSG00000189337 E004 1.4017517 0.0130728700 8.763490e-01 9.246389e-01 1 14598685 14598703 19 + 0.357 0.368 0.067
ENSG00000189337 E005 2.1370639 0.0519734326 8.667539e-01 9.182444e-01 1 14598704 14598716 13 + 0.464 0.481 0.085
ENSG00000189337 E006 6.5731047 0.0252401465 2.037576e-01 3.309119e-01 1 14598717 14598910 194 + 0.920 0.805 -0.443
ENSG00000189337 E007 4.4942406 0.0037601519 9.150785e-01 9.502293e-01 1 14598911 14598982 72 + 0.711 0.753 0.171
ENSG00000189337 E008 8.4370265 0.0249087648 3.762656e-01 5.206096e-01 1 14598983 14599223 241 + 0.996 0.940 -0.210
ENSG00000189337 E009 14.6961672 0.0012677317 9.305206e-08 9.502687e-07 1 14924130 14924572 443 + 1.367 0.953 -1.481
ENSG00000189337 E010 0.3729606 0.0303361140 9.343060e-01 9.625713e-01 1 14929800 14930044 245 + 0.120 0.125 0.066
ENSG00000189337 E011 0.1817044 0.0421627911 5.371704e-01   1 14945919 14946173 255 + 0.000 0.125 9.811
ENSG00000189337 E012 54.6037739 0.0004308259 8.430002e-02 1.662993e-01 1 14960684 14960875 192 + 1.749 1.737 -0.040
ENSG00000189337 E013 62.4240534 0.0006136465 3.207446e-02 7.600072e-02 1 15034749 15034885 137 + 1.815 1.789 -0.087
ENSG00000189337 E014 71.0290270 0.0016685263 5.538023e-01 6.828925e-01 1 15043989 15044159 171 + 1.830 1.871 0.140
ENSG00000189337 E015 71.2181549 0.0146209010 6.293751e-01 7.447430e-01 1 15056091 15056280 190 + 1.836 1.869 0.111
ENSG00000189337 E016 61.4603037 0.0007021313 1.126081e-02 3.178568e-02 1 15060172 15060302 131 + 1.815 1.770 -0.151
ENSG00000189337 E017 29.8935664 0.0007083634 1.154677e-04 5.930460e-04 1 15060303 15063571 3269 + 1.572 1.397 -0.599
ENSG00000189337 E018 48.1736988 0.0042045526 8.844894e-02 1.727534e-01 1 15063572 15063622 51 + 1.702 1.673 -0.099
ENSG00000189337 E019 61.5604776 0.0051199070 2.441992e-01 3.791442e-01 1 15065630 15065753 124 + 1.789 1.795 0.023
ENSG00000189337 E020 494.5263328 0.0055887542 7.294722e-11 1.316782e-09 1 15065754 15068155 2402 + 2.555 2.786 0.771
ENSG00000189337 E021 4.8819566 0.0068594312 1.767918e-03 6.497251e-03 1 15094180 15094385 206 + 0.937 0.563 -1.523
ENSG00000189337 E022 3.2631212 0.0159986888 2.679021e-01 4.062828e-01 1 15094815 15094933 119 + 0.683 0.564 -0.521
ENSG00000189337 E023 0.0000000       1 15094934 15094958 25 +      
ENSG00000189337 E024 6.5380145 0.0518914181 5.931631e-03 1.842844e-02 1 15101543 15101774 232 + 1.037 0.667 -1.442
ENSG00000189337 E025 3.9996981 0.0039295688 1.094774e-05 7.207703e-05 1 15103359 15103460 102 + 0.920 0.301 -2.875
ENSG00000189337 E026 4.3694365 0.0037780184 1.544543e-04 7.668170e-04 1 15104023 15104189 167 + 0.920 0.426 -2.138
ENSG00000189337 E027 4.2804745 0.0065141363 2.664037e-02 6.524553e-02 1 15112427 15112541 115 + 0.828 0.564 -1.103
ENSG00000189337 E028 96.8671269 0.0037978497 3.709682e-04 1.662106e-03 1 15114471 15118043 3573 + 2.035 1.949 -0.289