ENSG00000189308

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340417 ENSG00000189308 HEK293_OSMI2_2hA HEK293_TMG_2hB LIN54 protein_coding protein_coding 5.50387 1.476541 8.676876 0.01440715 0.617297 2.546878 0.6737523 0.38898683 1.1293186 0.06466359 0.03936083 1.513758 0.15247500 0.264266667 0.13133333 -0.1329333 0.03542149 0.03542149 FALSE TRUE
ENST00000446851 ENSG00000189308 HEK293_OSMI2_2hA HEK293_TMG_2hB LIN54 protein_coding protein_coding 5.50387 1.476541 8.676876 0.01440715 0.617297 2.546878 1.8048767 0.71527899 2.5934218 0.09176554 0.30543502 1.843801 0.40297917 0.485566667 0.29680000 -0.1887667 0.05851058 0.03542149 FALSE TRUE
ENST00000505397 ENSG00000189308 HEK293_OSMI2_2hA HEK293_TMG_2hB LIN54 protein_coding protein_coding 5.50387 1.476541 8.676876 0.01440715 0.617297 2.546878 2.1766348 0.29559305 3.7583290 0.13012135 0.44290562 3.624241 0.29183333 0.198533333 0.43056667 0.2320333 0.08238607 0.03542149 FALSE TRUE
ENST00000510557 ENSG00000189308 HEK293_OSMI2_2hA HEK293_TMG_2hB LIN54 protein_coding protein_coding 5.50387 1.476541 8.676876 0.01440715 0.617297 2.546878 0.2350186 0.01003867 0.6140193 0.01003867 0.15799421 4.960732 0.03440833 0.006833333 0.07303333 0.0662000 0.06285039 0.03542149 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000189308 E001 0.0000000       4 82909973 82910267 295 -      
ENSG00000189308 E002 0.0000000       4 82913231 82913441 211 -      
ENSG00000189308 E003 0.1472490 0.0450452751 1.000000e+00   4 82924603 82924635 33 - 0.056 0.000 -7.054
ENSG00000189308 E004 0.7458221 0.0297656747 8.652802e-01 0.9172007189 4 82924636 82924689 54 - 0.191 0.247 0.472
ENSG00000189308 E005 1.5701067 0.1886232640 3.780890e-01 0.5223843716 4 82924690 82924850 161 - 0.295 0.517 1.236
ENSG00000189308 E006 20.3550393 0.0009483035 2.341697e-03 0.0082814218 4 82924851 82925547 697 - 1.145 1.457 1.091
ENSG00000189308 E007 5.2955203 0.1464947841 3.729613e-02 0.0860288952 4 82925548 82925714 167 - 0.541 1.061 2.086
ENSG00000189308 E008 142.3157450 0.0234792315 6.508406e-05 0.0003563269 4 82925715 82927559 1845 - 1.961 2.291 1.105
ENSG00000189308 E009 11.6608245 0.0021770104 7.773141e-01 0.8566956979 4 82927560 82927585 26 - 0.993 1.009 0.061
ENSG00000189308 E010 18.5894337 0.0016723137 8.893880e-01 0.9332972871 4 82927586 82927776 191 - 1.174 1.214 0.139
ENSG00000189308 E011 21.0777728 0.0022927117 1.345094e-01 0.2404158879 4 82927777 82928055 279 - 1.194 1.381 0.655
ENSG00000189308 E012 49.6053085 0.0005082572 9.902376e-01 0.9980154207 4 82928056 82928303 248 - 1.581 1.636 0.185
ENSG00000189308 E013 49.7673840 0.0027524969 3.600912e-01 0.5044045771 4 82930943 82931145 203 - 1.592 1.587 -0.017
ENSG00000189308 E014 46.4039481 0.0006561454 9.954983e-01 1.0000000000 4 82935981 82936118 138 - 1.549 1.604 0.188
ENSG00000189308 E015 32.3021119 0.0041622525 6.298628e-01 0.7451572959 4 82936279 82936381 103 - 1.408 1.420 0.044
ENSG00000189308 E016 28.6874140 0.0006992147 7.519063e-01 0.8382601554 4 82937227 82937298 72 - 1.353 1.381 0.097
ENSG00000189308 E017 29.5712218 0.0043185030 3.666881e-01 0.5110342636 4 82938413 82938504 92 - 1.376 1.352 -0.081
ENSG00000189308 E018 42.9300569 0.0005613861 6.590754e-02 0.1365528735 4 82939539 82939736 198 - 1.543 1.468 -0.258
ENSG00000189308 E019 25.1035240 0.0144869454 5.653757e-02 0.1206561266 4 82939889 82939962 74 - 1.334 1.169 -0.578
ENSG00000189308 E020 40.8109782 0.0073835418 2.841275e-02 0.0688422987 4 82946258 82946474 217 - 1.530 1.395 -0.465
ENSG00000189308 E021 34.4321920 0.0037463601 7.119126e-04 0.0029413497 4 82970327 82970465 139 - 1.471 1.214 -0.894
ENSG00000189308 E022 13.4333465 0.0015202700 1.242329e-03 0.0047844265 4 82970466 82970469 4 - 1.100 0.685 -1.595
ENSG00000189308 E023 29.9086201 0.0008694852 5.915129e-04 0.0025023522 4 82978883 82979006 124 - 1.415 1.148 -0.937
ENSG00000189308 E024 10.5614112 0.0017504539 5.766463e-01 0.7020275941 4 82984161 82984161 1 - 0.961 0.938 -0.085
ENSG00000189308 E025 60.4391640 0.0004163433 1.564049e-01 0.2703339339 4 82984162 82984717 556 - 1.678 1.651 -0.092
ENSG00000189308 E026 18.7251246 0.0036057292 5.107252e-02 0.1110823513 4 82984718 82984823 106 - 1.209 1.041 -0.605
ENSG00000189308 E027 16.0044824 0.0010869764 1.016315e-01 0.1929797714 4 82984824 82984876 53 - 1.145 1.009 -0.494
ENSG00000189308 E028 3.4586621 0.0564721265 2.971538e-01 0.4384619802 4 83010484 83010746 263 - 0.591 0.403 -0.923
ENSG00000189308 E029 0.8942170 0.0136230713 2.915446e-01 0.4324106853 4 83010747 83010823 77 - 0.262 0.000 -9.634
ENSG00000189308 E030 9.6452114 0.0017284875 3.207489e-01 0.4639180858 4 83012792 83012926 135 - 0.941 0.854 -0.332