ENSG00000189283

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000466788 ENSG00000189283 HEK293_OSMI2_2hA HEK293_TMG_2hB FHIT protein_coding processed_transcript 10.30076 15.76017 11.00634 0.3737339 0.3256097 -0.5175532 0.6465104 0.34999623 0.8584947 0.04611369 0.08193443 1.2705353 0.07427917 0.02236667 0.07803333 0.05566667 0.0000874558 8.74558e-05 TRUE  
ENST00000468189 ENSG00000189283 HEK293_OSMI2_2hA HEK293_TMG_2hB FHIT protein_coding protein_coding 10.30076 15.76017 11.00634 0.3737339 0.3256097 -0.5175532 0.1706399 0.04748749 0.6036785 0.02436760 0.30798664 3.4161631 0.01914583 0.00300000 0.05616667 0.05316667 0.0401041417 8.74558e-05 FALSE  
ENST00000476844 ENSG00000189283 HEK293_OSMI2_2hA HEK293_TMG_2hB FHIT protein_coding protein_coding 10.30076 15.76017 11.00634 0.3737339 0.3256097 -0.5175532 6.1659457 9.60046521 6.5145539 0.45309055 0.58307808 -0.5587270 0.58906250 0.60880000 0.59040000 -0.01840000 0.9157972382 8.74558e-05 FALSE  
MSTRG.23171.3 ENSG00000189283 HEK293_OSMI2_2hA HEK293_TMG_2hB FHIT protein_coding   10.30076 15.76017 11.00634 0.3737339 0.3256097 -0.5175532 1.3875440 2.98173741 1.0067538 0.26613404 0.40196565 -1.5570132 0.12931667 0.19020000 0.09380000 -0.09640000 0.2093189430 8.74558e-05    
MSTRG.23171.4 ENSG00000189283 HEK293_OSMI2_2hA HEK293_TMG_2hB FHIT protein_coding   10.30076 15.76017 11.00634 0.3737339 0.3256097 -0.5175532 1.2443983 1.93927525 1.0819890 0.23875806 0.65818737 -0.8359796 0.12244167 0.12273333 0.09653333 -0.02620000 0.7701913147 8.74558e-05    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000189283 E001 5.9506364 0.0189189814 1.013700e-01 1.925565e-01 3 59747277 59749309 2033 - 0.956 0.722 -0.914
ENSG00000189283 E002 7.9874656 0.0584928385 3.151996e-01 4.579476e-01 3 59749310 59749342 33 - 1.031 0.863 -0.630
ENSG00000189283 E003 12.6661637 0.0200208366 7.347695e-01 8.256563e-01 3 59749343 59749354 12 - 1.094 1.127 0.119
ENSG00000189283 E004 74.5290693 0.0041728324 3.681239e-02 8.510999e-02 3 59749355 59749568 214 - 1.786 1.884 0.330
ENSG00000189283 E005 20.3650498 0.0010347871 1.010295e-01 1.920297e-01 3 59749569 59749579 11 - 1.221 1.343 0.426
ENSG00000189283 E006 37.4243600 0.0138186192 3.616555e-10 5.807795e-09 3 59749702 59751406 1705 - 1.824 1.320 -1.724
ENSG00000189283 E007 18.5978574 0.0136460680 2.281599e-12 5.279616e-11 3 59751407 59752220 814 - 1.601 0.915 -2.428
ENSG00000189283 E008 80.5828520 0.0004169472 1.471375e-02 3.984555e-02 3 59752221 59752321 101 - 1.823 1.912 0.298
ENSG00000189283 E009 0.1472490 0.0425040682 3.041920e-01   3 59886220 59886287 68 - 0.153 0.000 -11.444
ENSG00000189283 E010 56.7538801 0.0100716715 9.546663e-01 9.755841e-01 3 59922346 59922414 69 - 1.748 1.735 -0.044
ENSG00000189283 E011 53.8913096 0.0049468564 4.682083e-01 6.076376e-01 3 60011371 60011400 30 - 1.751 1.700 -0.174
ENSG00000189283 E012 43.2092109 0.0005712945 1.393601e-01 2.471689e-01 3 60014007 60014019 13 - 1.681 1.591 -0.304
ENSG00000189283 E013 60.5509630 0.0004445170 4.616977e-01 6.016084e-01 3 60014020 60014075 56 - 1.795 1.751 -0.149
ENSG00000189283 E014 62.8141266 0.0004285020 8.345531e-01 8.964363e-01 3 60014076 60014152 77 - 1.792 1.771 -0.069
ENSG00000189283 E015 0.7665583 0.2103233079 1.464571e-01 2.568657e-01 3 60077370 60077526 157 - 0.000 0.305 11.479
ENSG00000189283 E016 0.1472490 0.0425040682 3.041920e-01   3 60080791 60080840 50 - 0.153 0.000 -11.444
ENSG00000189283 E017 0.8868276 0.0251909503 3.281538e-01 4.716253e-01 3 60535810 60536714 905 - 0.356 0.177 -1.337
ENSG00000189283 E018 12.0173823 0.0294898131 1.382355e-02 3.782688e-02 3 60536715 60536756 42 - 0.840 1.165 1.204
ENSG00000189283 E019 22.6704144 0.0493384751 2.036968e-01 3.308250e-01 3 60536757 60536859 103 - 1.244 1.386 0.496
ENSG00000189283 E020 105.0717469 0.0003597471 5.641035e-01 6.914587e-01 3 60536860 60536979 120 - 1.991 2.000 0.030
ENSG00000189283 E021 2.4399930 0.0086376240 7.058217e-01 8.041099e-01 3 60765524 60765563 40 - 0.549 0.478 -0.339
ENSG00000189283 E022 87.4199420 0.0003151910 1.151560e-03 4.476630e-03 3 60821919 60822011 93 - 1.840 1.956 0.392
ENSG00000189283 E023 74.1268063 0.0004398094 1.057648e-03 4.158829e-03 3 61042047 61042099 53 - 1.761 1.891 0.439
ENSG00000189283 E024 6.3251463 0.1828869720 2.224660e-02 5.618504e-02 3 61165575 61165828 254 - 1.108 0.590 -2.032
ENSG00000189283 E025 3.2638022 0.0146105618 2.935463e-03 1.007373e-02 3 61166973 61167042 70 - 0.866 0.398 -2.078
ENSG00000189283 E026 68.0778443 0.0004114117 5.569458e-02 1.191724e-01 3 61200617 61200665 49 - 1.761 1.835 0.249
ENSG00000189283 E027 0.7780993 0.0171996524 4.019517e-01 5.456603e-01 3 61244010 61244150 141 - 0.153 0.301 1.239
ENSG00000189283 E028 72.2016168 0.0004139744 6.326696e-01 7.474807e-01 3 61251301 61251459 159 - 1.858 1.827 -0.104