ENSG00000189180

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000432900 ENSG00000189180 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF33A protein_coding protein_coding 6.982667 4.480372 10.10293 0.09633825 0.6799757 1.171295 2.0173651 0.6857113 3.54085821 0.14770015 0.28391804 2.35160701 0.25930833 0.15456667 0.35193333 0.19736667 0.01418009 0.01418009 FALSE TRUE
ENST00000458705 ENSG00000189180 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF33A protein_coding protein_coding 6.982667 4.480372 10.10293 0.09633825 0.6799757 1.171295 0.8426819 0.3356298 0.60696690 0.16839091 0.35489116 0.83596541 0.11870417 0.07400000 0.06213333 -0.01186667 0.96708375 0.01418009 FALSE TRUE
ENST00000469037 ENSG00000189180 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF33A protein_coding protein_coding 6.982667 4.480372 10.10293 0.09633825 0.6799757 1.171295 0.6359291 0.6269473 0.59679883 0.47861142 0.16100147 -0.06995574 0.09821250 0.13593333 0.05993333 -0.07600000 0.97657403 0.01418009 FALSE TRUE
ENST00000476504 ENSG00000189180 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF33A protein_coding processed_transcript 6.982667 4.480372 10.10293 0.09633825 0.6799757 1.171295 0.1268064 0.2956905 0.06174983 0.29569054 0.06174983 -2.09102453 0.02962917 0.06686667 0.00600000 -0.06086667 0.90329279 0.01418009 FALSE TRUE
MSTRG.3801.1 ENSG00000189180 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF33A protein_coding   6.982667 4.480372 10.10293 0.09633825 0.6799757 1.171295 0.4503435 0.1809503 0.64090276 0.18095029 0.64090276 1.76924489 0.06660000 0.03876667 0.06233333 0.02356667 0.92368558 0.01418009 FALSE TRUE
MSTRG.3801.2 ENSG00000189180 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF33A protein_coding   6.982667 4.480372 10.10293 0.09633825 0.6799757 1.171295 0.2628597 0.8231907 0.28575106 0.44219423 0.28575106 -1.49426346 0.05387083 0.18736667 0.02556667 -0.16180000 0.43429410 0.01418009 FALSE TRUE
MSTRG.3801.3 ENSG00000189180 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF33A protein_coding   6.982667 4.480372 10.10293 0.09633825 0.6799757 1.171295 0.6502316 0.3569245 0.72253760 0.09121279 0.31916013 0.99741963 0.08875833 0.08043333 0.06926667 -0.01116667 0.88975598 0.01418009 TRUE TRUE
MSTRG.3801.8 ENSG00000189180 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF33A protein_coding   6.982667 4.480372 10.10293 0.09633825 0.6799757 1.171295 0.8001487 0.5277468 1.67096655 0.26484936 0.21047296 1.64429207 0.11900000 0.11580000 0.16503333 0.04923333 0.65006072 0.01418009 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000189180 E001 0.0000000       10 38010573 38010600 28 +      
ENSG00000189180 E002 0.0000000       10 38010601 38010605 5 +      
ENSG00000189180 E003 0.0000000       10 38010606 38010615 10 +      
ENSG00000189180 E004 0.4804688 0.0212105734 8.885471e-01 9.327403e-01 10 38010616 38010649 34 + 0.169 0.160 -0.085
ENSG00000189180 E005 1.1437748 0.0116371530 9.556487e-01 9.761666e-01 10 38010650 38010654 5 + 0.339 0.278 -0.406
ENSG00000189180 E006 1.2889475 0.0109172425 7.773695e-01 8.567390e-01 10 38010655 38010657 3 + 0.384 0.278 -0.669
ENSG00000189180 E007 2.7742609 0.0058821940 7.399473e-01 8.295015e-01 10 38010658 38010668 11 + 0.585 0.566 -0.086
ENSG00000189180 E008 2.7742609 0.0058821940 7.399473e-01 8.295015e-01 10 38010669 38010669 1 + 0.585 0.566 -0.086
ENSG00000189180 E009 4.2951611 0.0060280490 2.299249e-01 3.623631e-01 10 38010670 38010674 5 + 0.681 0.772 0.373
ENSG00000189180 E010 6.3527447 0.0081277590 1.797307e-01 3.008219e-01 10 38010675 38010685 11 + 0.825 0.911 0.328
ENSG00000189180 E011 7.8336900 0.0140579187 5.658009e-02 1.207250e-01 10 38010686 38010692 7 + 0.883 1.032 0.558
ENSG00000189180 E012 9.3879908 0.0114097556 1.272762e-01 2.303433e-01 10 38010693 38010698 6 + 0.979 1.067 0.323
ENSG00000189180 E013 11.0163886 0.0137434317 2.937596e-01 4.348083e-01 10 38010699 38010703 5 + 1.067 1.098 0.113
ENSG00000189180 E014 48.0061779 0.0005383376 1.922327e-03 6.984638e-03 10 38010704 38010783 80 + 1.659 1.719 0.205
ENSG00000189180 E015 58.2095022 0.0028892766 1.772049e-03 6.510285e-03 10 38012298 38012350 53 + 1.739 1.802 0.215
ENSG00000189180 E016 2.7646971 0.0055921785 8.635469e-01 9.159916e-01 10 38015967 38016045 79 + 0.611 0.510 -0.464
ENSG00000189180 E017 39.8628077 0.0005831961 6.422480e-02 1.337422e-01 10 38016871 38016874 4 + 1.603 1.610 0.024
ENSG00000189180 E018 88.5307514 0.0003151160 2.751018e-06 2.077106e-05 10 38016875 38017015 141 + 1.914 1.989 0.251
ENSG00000189180 E019 1.8498561 0.0077113932 7.248210e-01 8.182437e-01 10 38017016 38017020 5 + 0.496 0.369 -0.671
ENSG00000189180 E020 76.0324584 0.0019766781 3.640316e-04 1.634815e-03 10 38017291 38017386 96 + 1.858 1.918 0.203
ENSG00000189180 E021 0.8815290 0.1953974736 2.069536e-01 3.348956e-01 10 38017387 38017707 321 + 0.168 0.373 1.524
ENSG00000189180 E022 3.8565225 0.0087745324 2.229378e-01 3.538803e-01 10 38034278 38034325 48 + 0.635 0.738 0.428
ENSG00000189180 E023 14.5436081 0.0247441113 9.738104e-01 9.876783e-01 10 38034326 38034400 75 + 1.222 1.127 -0.338
ENSG00000189180 E024 31.4365891 0.0011987709 5.122935e-01 6.471978e-01 10 38054375 38054377 3 + 1.525 1.471 -0.184
ENSG00000189180 E025 59.0169152 0.0004608616 1.275165e-01 2.306936e-01 10 38054378 38054479 102 + 1.782 1.755 -0.092
ENSG00000189180 E026 15.9906143 0.0179755845 8.445061e-01 9.031995e-01 10 38054480 38054511 32 + 1.268 1.155 -0.398
ENSG00000189180 E027 437.7778463 0.0137908921 2.340839e-07 2.214999e-06 10 38054512 38060087 5576 + 2.727 2.419 -1.026
ENSG00000189180 E028 76.4293621 0.0073858201 4.710809e-04 2.049458e-03 10 38064088 38065088 1001 + 1.844 1.934 0.303