ENSG00000189164

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356178 ENSG00000189164 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF527 protein_coding nonsense_mediated_decay 2.273685 2.093775 2.242539 0.2756953 0.1264219 0.09857168 0.2168759 0.08315868 0.3463634 0.08315868 0.17319954 1.935587 0.08797083 0.03146667 0.14663333 0.1151667 4.696624e-01 1.760947e-10 FALSE TRUE
ENST00000436120 ENSG00000189164 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF527 protein_coding protein_coding 2.273685 2.093775 2.242539 0.2756953 0.1264219 0.09857168 0.3259607 0.16817935 0.1847909 0.08582131 0.18479088 0.128596 0.14415000 0.09226667 0.09136667 -0.0009000 7.251327e-01 1.760947e-10 FALSE TRUE
ENST00000483919 ENSG00000189164 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF527 protein_coding protein_coding 2.273685 2.093775 2.242539 0.2756953 0.1264219 0.09857168 0.8169483 1.52864703 0.4836909 0.25730731 0.03980034 -1.639982 0.38120000 0.72410000 0.21906667 -0.5050333 1.760947e-10 1.760947e-10 FALSE TRUE
ENST00000588512 ENSG00000189164 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF527 protein_coding nonsense_mediated_decay 2.273685 2.093775 2.242539 0.2756953 0.1264219 0.09857168 0.2557249 0.00000000 0.4835239 0.00000000 0.10703701 5.625048 0.10352917 0.00000000 0.21253333 0.2125333 3.079002e-07 1.760947e-10 FALSE TRUE
ENST00000588911 ENSG00000189164 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF527 protein_coding protein_coding 2.273685 2.093775 2.242539 0.2756953 0.1264219 0.09857168 0.1340649 0.01925467 0.3056674 0.01925467 0.15304072 3.431667 0.05136667 0.00730000 0.14380000 0.1365000 4.311875e-02 1.760947e-10 FALSE TRUE
ENST00000589615 ENSG00000189164 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF527 protein_coding processed_transcript 2.273685 2.093775 2.242539 0.2756953 0.1264219 0.09857168 0.4336862 0.20847185 0.4385029 0.10482564 0.21943993 1.037670 0.18721250 0.09650000 0.18660000 0.0901000 8.764680e-01 1.760947e-10   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000189164 E001 1.266032 0.047872476 3.501296e-01 4.943176e-01 19 37371061 37371098 38 + 0.418 0.252 -1.045
ENSG00000189164 E002 1.783019 0.107892309 7.680753e-01 8.501426e-01 19 37371099 37371158 60 + 0.461 0.411 -0.265
ENSG00000189164 E003 1.340228 0.081474572 8.393129e-01 8.995854e-01 19 37371159 37371160 2 + 0.371 0.339 -0.189
ENSG00000189164 E004 1.633694 0.009050751 9.141173e-01 9.495903e-01 19 37371161 37371176 16 + 0.418 0.410 -0.044
ENSG00000189164 E005 1.772524 0.008393036 7.214896e-01 8.158532e-01 19 37371177 37371180 4 + 0.461 0.410 -0.267
ENSG00000189164 E006 2.218537 0.007243862 3.138629e-01 4.565019e-01 19 37371181 37371193 13 + 0.568 0.410 -0.781
ENSG00000189164 E007 6.995761 0.002706566 7.327489e-01 8.241581e-01 19 37371194 37371226 33 + 0.874 0.927 0.204
ENSG00000189164 E008 10.718173 0.001816963 7.845245e-01 8.617588e-01 19 37374158 37374231 74 + 1.051 1.093 0.150
ENSG00000189164 E009 18.267327 0.002468427 4.461817e-01 5.876939e-01 19 37379120 37379236 117 + 1.249 1.323 0.259
ENSG00000189164 E010 9.109817 0.002146932 8.931041e-03 2.610604e-02 19 37379237 37379246 10 + 0.841 1.132 1.082
ENSG00000189164 E011 1.686698 0.264119278 7.029682e-01 8.017097e-01 19 37379487 37379692 206 + 0.371 0.478 0.573
ENSG00000189164 E012 2.572876 0.135548634 2.316074e-01 3.643813e-01 19 37380048 37380276 229 + 0.655 0.405 -1.194
ENSG00000189164 E013 17.492643 0.004688772 3.261188e-03 1.103550e-02 19 37380277 37380372 96 + 1.128 1.383 0.900
ENSG00000189164 E014 8.478507 0.002146932 1.423084e-11 2.889746e-10 19 37384868 37384981 114 + 0.418 1.252 3.381
ENSG00000189164 E015 13.158227 0.021835918 4.102796e-09 5.428150e-08 19 37384982 37385304 323 + 0.703 1.415 2.629
ENSG00000189164 E016 8.633148 0.007424880 7.412275e-06 5.072364e-05 19 37385305 37385379 75 + 0.679 1.210 2.011
ENSG00000189164 E017 8.376127 0.040686902 1.045894e-04 5.432254e-04 19 37385380 37385644 265 + 0.627 1.211 2.237
ENSG00000189164 E018 77.003807 0.001203144 2.308650e-39 7.686587e-37 19 37388306 37392414 4109 + 2.045 1.578 -1.574
ENSG00000189164 E019 4.080609 0.004512174 5.207896e-01 6.547351e-01 19 37392415 37393066 652 + 0.654 0.757 0.425