ENSG00000189144

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000494605 ENSG00000189144 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF573 protein_coding processed_transcript 1.819646 1.282816 2.136534 0.1422798 0.369081 0.7314922 0.30271254 0.56200507 0.2205112 0.09409436 0.09999895 -1.311191 0.19251667 0.43236667 0.1320000 -0.30036667 6.225672e-02 5.134118e-06 TRUE FALSE
ENST00000536220 ENSG00000189144 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF573 protein_coding protein_coding 1.819646 1.282816 2.136534 0.1422798 0.369081 0.7314922 0.08793311 0.00000000 0.1789047 0.00000000 0.08996346 4.239587 0.03845000 0.00000000 0.1021000 0.10210000 3.220126e-01 5.134118e-06 FALSE TRUE
ENST00000586155 ENSG00000189144 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF573 protein_coding nonsense_mediated_decay 1.819646 1.282816 2.136534 0.1422798 0.369081 0.7314922 0.23814785 0.05945527 0.2912803 0.03594189 0.06257332 2.116950 0.13309167 0.05353333 0.1354000 0.08186667 2.426060e-01 5.134118e-06 FALSE TRUE
ENST00000589632 ENSG00000189144 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF573 protein_coding nonsense_mediated_decay 1.819646 1.282816 2.136534 0.1422798 0.369081 0.7314922 0.12697284 0.07352159 0.2920793 0.01318091 0.03469338 1.854706 0.07610833 0.05646667 0.1416333 0.08516667 2.177987e-01 5.134118e-06 FALSE TRUE
ENST00000590674 ENSG00000189144 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF573 protein_coding processed_transcript 1.819646 1.282816 2.136534 0.1422798 0.369081 0.7314922 0.77533378 0.10927092 0.8060159 0.10927092 0.41347127 2.774355 0.35685000 0.07430000 0.3230667 0.24876667 5.354751e-01 5.134118e-06   FALSE
ENST00000591516 ENSG00000189144 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF573 protein_coding nonsense_mediated_decay 1.819646 1.282816 2.136534 0.1422798 0.369081 0.7314922 0.09923834 0.30554462 0.0000000 0.05176328 0.00000000 -4.979772 0.08804583 0.25496667 0.0000000 -0.25496667 5.134118e-06 5.134118e-06 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000189144 E001 2.7002788 0.009176680 3.546851e-01 4.990162e-01 19 37735833 37735865 33 - 0.618 0.439 -0.851
ENSG00000189144 E002 2.9625116 0.007301874 7.621932e-02 1.534542e-01 19 37735866 37736014 149 - 0.689 0.364 -1.566
ENSG00000189144 E003 0.2966881 0.029078516 4.491247e-01   19 37738287 37738301 15 - 0.172 0.000 -11.948
ENSG00000189144 E004 15.4488619 0.001287901 3.807259e-12 8.492569e-11 19 37738302 37739905 1604 - 1.385 0.608 -2.929
ENSG00000189144 E005 1.9123885 0.026771258 2.424526e-03 8.535627e-03 19 37739906 37739933 28 - 0.618 0.000 -14.050
ENSG00000189144 E006 1.6480794 0.042071032 6.391547e-02 1.332123e-01 19 37739934 37739945 12 - 0.534 0.157 -2.471
ENSG00000189144 E007 3.0520106 0.010030985 1.338604e-02 3.681366e-02 19 37739946 37740060 115 - 0.730 0.273 -2.320
ENSG00000189144 E008 1.4791742 0.011223109 7.755455e-03 2.316475e-02 19 37740061 37740083 23 - 0.535 0.000 -13.784
ENSG00000189144 E009 3.8954372 0.008315827 4.627259e-02 1.025359e-01 19 37740084 37740180 97 - 0.785 0.439 -1.543
ENSG00000189144 E010 2.8538575 0.006643068 2.782113e-01 4.178529e-01 19 37740181 37740194 14 - 0.643 0.439 -0.958
ENSG00000189144 E011 0.1515154 0.042379706 1.000000e+00   19 37740641 37740710 70 - 0.094 0.000 -11.065
ENSG00000189144 E012 0.5149111 0.022031865 2.532411e-01 3.897382e-01 19 37755201 37755261 61 - 0.094 0.273 1.849
ENSG00000189144 E013 1.6523286 0.302163924 3.807659e-01 5.250609e-01 19 37758476 37758596 121 - 0.294 0.522 1.266
ENSG00000189144 E014 1.1770843 0.011181270 2.146154e-01 3.439936e-01 19 37759047 37759139 93 - 0.237 0.439 1.264
ENSG00000189144 E015 4.5405423 0.003848360 8.361778e-01 8.975709e-01 19 37770005 37770038 34 - 0.749 0.693 -0.229
ENSG00000189144 E016 6.5083888 0.003038917 5.114313e-01 6.464698e-01 19 37770039 37770097 59 - 0.905 0.795 -0.425
ENSG00000189144 E017 8.5247728 0.007231412 1.033544e-05 6.848615e-05 19 37770407 37770597 191 - 0.730 1.187 1.721
ENSG00000189144 E018 17.7370527 0.001379275 7.868981e-03 2.345065e-02 19 37771564 37771690 127 - 1.192 1.358 0.585
ENSG00000189144 E019 9.3165094 0.002725066 5.242308e-01 6.578380e-01 19 37771691 37771696 6 - 0.988 1.026 0.138
ENSG00000189144 E020 3.0603530 0.005378022 7.010323e-01 8.003673e-01 19 37772938 37772982 45 - 0.643 0.558 -0.375
ENSG00000189144 E021 11.0120411 0.002118309 1.083077e-02 3.076018e-02 19 37773661 37773751 91 - 0.977 1.188 0.763
ENSG00000189144 E022 0.1472490 0.043660006 1.000000e+00   19 37778433 37778546 114 - 0.094 0.000 -11.065
ENSG00000189144 E023 9.7029169 0.002146932 4.480882e-05 2.554204e-04 19 37779544 37779878 335 - 0.834 1.212 1.392
ENSG00000189144 E024 0.0000000       19 37792570 37792853 284 -      
ENSG00000189144 E025 0.0000000       19 37793433 37793629 197 -      
ENSG00000189144 E026 0.0000000       19 37793630 37793727 98 -      
ENSG00000189144 E027 0.0000000       19 37793976 37794034 59 -      
ENSG00000189144 E028 0.0000000       19 37794035 37794055 21 -      
ENSG00000189144 E029 0.0000000       19 37794141 37794245 105 -      
ENSG00000189144 E030 0.0000000       19 37799112 37799163 52 -      
ENSG00000189144 E031 0.0000000       19 37810605 37810800 196 -      
ENSG00000189144 E032 0.0000000       19 37817061 37817300 240 -