ENSG00000189091

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000302516 ENSG00000189091 HEK293_OSMI2_2hA HEK293_TMG_2hB SF3B3 protein_coding protein_coding 234.1112 219.4383 243.0404 26.70149 7.215892 0.147374 11.23037 19.13038 6.755481 1.505434 0.2653462 -1.5003551 0.04978750 0.08910000 0.02780000 -0.06130000 1.071448e-09 4.03021e-67 FALSE TRUE
ENST00000563739 ENSG00000189091 HEK293_OSMI2_2hA HEK293_TMG_2hB SF3B3 protein_coding retained_intron 234.1112 219.4383 243.0404 26.70149 7.215892 0.147374 41.15778 49.10590 33.881422 2.647599 1.2041638 -0.5352698 0.17844167 0.22890000 0.13990000 -0.08900000 2.254419e-02 4.03021e-67 FALSE TRUE
ENST00000567635 ENSG00000189091 HEK293_OSMI2_2hA HEK293_TMG_2hB SF3B3 protein_coding nonsense_mediated_decay 234.1112 219.4383 243.0404 26.70149 7.215892 0.147374 30.01250 21.04459 35.507760 5.336650 0.7361320 0.7544058 0.12690417 0.09316667 0.14616667 0.05300000 2.321170e-02 4.03021e-67   FALSE
ENST00000567654 ENSG00000189091 HEK293_OSMI2_2hA HEK293_TMG_2hB SF3B3 protein_coding protein_coding 234.1112 219.4383 243.0404 26.70149 7.215892 0.147374 11.35389 0.00000 18.352164 0.000000 2.0595339 10.8425204 0.04557917 0.00000000 0.07513333 0.07513333 4.030210e-67 4.03021e-67 FALSE FALSE
ENST00000568539 ENSG00000189091 HEK293_OSMI2_2hA HEK293_TMG_2hB SF3B3 protein_coding retained_intron 234.1112 219.4383 243.0404 26.70149 7.215892 0.147374 43.34653 36.53491 44.363835 4.248391 0.1812357 0.2800389 0.18475833 0.16673333 0.18286667 0.01613333 3.816270e-01 4.03021e-67 FALSE FALSE
ENST00000572365 ENSG00000189091 HEK293_OSMI2_2hA HEK293_TMG_2hB SF3B3 protein_coding retained_intron 234.1112 219.4383 243.0404 26.70149 7.215892 0.147374 21.75258 14.50191 28.882522 9.092078 4.0879738 0.9934586 0.09065000 0.05993333 0.11806667 0.05813333 4.513300e-01 4.03021e-67 FALSE FALSE
MSTRG.12933.3 ENSG00000189091 HEK293_OSMI2_2hA HEK293_TMG_2hB SF3B3 protein_coding   234.1112 219.4383 243.0404 26.70149 7.215892 0.147374 46.45074 61.41235 38.199406 3.888028 0.5126153 -0.6848359 0.20096250 0.28360000 0.15736667 -0.12623333 3.029262e-08 4.03021e-67 TRUE TRUE
MSTRG.12933.5 ENSG00000189091 HEK293_OSMI2_2hA HEK293_TMG_2hB SF3B3 protein_coding   234.1112 219.4383 243.0404 26.70149 7.215892 0.147374 16.00716 12.63382 16.278995 2.492285 0.9770150 0.3654646 0.06805833 0.05663333 0.06720000 0.01056667 6.303566e-01 4.03021e-67 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000189091 E001 0.6621601 0.0167772833 6.324287e-01 7.472913e-01 16 70523670 70523790 121 + 0.261 0.180 -0.677
ENSG00000189091 E002 0.5890081 0.0292610051 6.283535e-01 7.438997e-01 16 70523791 70523797 7 + 0.261 0.180 -0.682
ENSG00000189091 E003 1.1373435 0.0138438280 7.956178e-01 8.694926e-01 16 70523798 70523798 1 + 0.349 0.307 -0.263
ENSG00000189091 E004 12.1438897 0.0026232368 1.127754e-05 7.403458e-05 16 70523799 70523804 6 + 1.326 0.914 -1.485
ENSG00000189091 E005 28.9648797 0.0104453534 1.599568e-05 1.014474e-04 16 70523805 70523812 8 + 1.649 1.307 -1.177
ENSG00000189091 E006 30.3612442 0.0105025727 7.593521e-05 4.087775e-04 16 70523813 70523815 3 + 1.653 1.344 -1.062
ENSG00000189091 E007 431.4622550 0.0113362124 1.566533e-06 1.246797e-05 16 70523816 70523892 77 + 2.764 2.508 -0.853
ENSG00000189091 E008 532.5762142 0.0137410201 7.805189e-05 4.187917e-04 16 70523893 70523928 36 + 2.838 2.614 -0.747
ENSG00000189091 E009 7.5890411 0.0022501335 1.277143e-05 8.278053e-05 16 70523929 70524055 127 + 1.176 0.686 -1.859
ENSG00000189091 E010 8.0864618 0.0020823043 7.662867e-06 5.227233e-05 16 70524550 70524863 314 + 1.199 0.709 -1.848
ENSG00000189091 E011 4.5987578 0.0134620199 4.862120e-03 1.554780e-02 16 70524864 70524866 3 + 0.945 0.553 -1.603
ENSG00000189091 E012 23.5344171 0.0073099412 1.296182e-05 8.385965e-05 16 70524867 70525017 151 + 1.561 1.216 -1.196
ENSG00000189091 E013 983.4415635 0.0087360838 6.221568e-07 5.401452e-06 16 70526587 70526726 140 + 3.104 2.880 -0.744
ENSG00000189091 E014 0.3332198 0.0299344035 7.223060e-01   16 70526901 70527014 114 + 0.150 0.099 -0.677
ENSG00000189091 E015 1687.0641097 0.0056042024 9.856995e-10 1.463577e-08 16 70528873 70529199 327 + 3.335 3.117 -0.726
ENSG00000189091 E016 1238.8245444 0.0033180588 1.487693e-10 2.549542e-09 16 70530745 70530917 173 + 3.184 2.998 -0.618
ENSG00000189091 E017 1126.2205287 0.0022271914 4.099480e-08 4.500140e-07 16 70532479 70532620 142 + 3.113 2.979 -0.445
ENSG00000189091 E018 968.9597348 0.0031033482 1.935401e-03 7.025944e-03 16 70535308 70535420 113 + 3.019 2.932 -0.290
ENSG00000189091 E019 799.8512662 0.0049057847 6.184657e-03 1.910115e-02 16 70538323 70538394 72 + 2.940 2.846 -0.311
ENSG00000189091 E020 813.6349964 0.0073396562 7.688646e-02 1.545159e-01 16 70538395 70538460 66 + 2.933 2.862 -0.235
ENSG00000189091 E021 974.3510520 0.0052893634 8.839625e-02 1.726647e-01 16 70539104 70539207 104 + 3.003 2.946 -0.192
ENSG00000189091 E022 838.0511783 0.0040980829 4.236197e-02 9.538088e-02 16 70541669 70541738 70 + 2.942 2.878 -0.215
ENSG00000189091 E023 1109.1394170 0.0043673350 8.185182e-03 2.425405e-02 16 70541739 70541834 96 + 3.077 2.991 -0.284
ENSG00000189091 E024 1136.0157496 0.0016099878 7.556172e-06 5.161328e-05 16 70544438 70544533 96 + 3.093 2.999 -0.312
ENSG00000189091 E025 1048.3673331 0.0011310592 3.074781e-08 3.452718e-07 16 70548370 70548442 73 + 3.064 2.960 -0.345
ENSG00000189091 E026 4.7353700 0.0615300500 4.790958e-02 1.054651e-01 16 70548443 70548512 70 + 0.924 0.587 -1.368
ENSG00000189091 E027 10.2165982 0.0023346333 7.031143e-12 1.502232e-10 16 70550203 70550649 447 + 1.358 0.638 -2.705
ENSG00000189091 E028 20.5209382 0.0008949529 1.780156e-12 4.187302e-11 16 70550650 70550678 29 + 1.585 1.062 -1.829
ENSG00000189091 E029 5.8986921 0.0551002992 2.846636e-02 6.894485e-02 16 70554106 70554445 340 + 1.021 0.662 -1.403
ENSG00000189091 E030 1428.1756347 0.0009673499 1.685853e-07 1.639275e-06 16 70554446 70554597 152 + 3.188 3.100 -0.293
ENSG00000189091 E031 1568.1367284 0.0006409814 3.322615e-05 1.954245e-04 16 70555051 70555206 156 + 3.210 3.153 -0.190
ENSG00000189091 E032 1701.2036343 0.0001688065 3.399314e-04 1.540019e-03 16 70556179 70556334 156 + 3.231 3.199 -0.104
ENSG00000189091 E033 12.7650011 0.0240151973 4.200199e-03 1.370387e-02 16 70556335 70556597 263 + 1.309 0.985 -1.162
ENSG00000189091 E034 1582.1871732 0.0003734510 9.605804e-01 9.791876e-01 16 70556886 70557029 144 + 3.174 3.181 0.024
ENSG00000189091 E035 4.0628015 0.0780116408 8.216367e-01 8.874849e-01 16 70560350 70560468 119 + 0.709 0.699 -0.042
ENSG00000189091 E036 1465.4806811 0.0001495281 1.951723e-02 5.045001e-02 16 70560469 70560591 123 + 3.123 3.156 0.109
ENSG00000189091 E037 1.1791475 0.0356670746 8.079342e-01 8.779556e-01 16 70561349 70561629 281 + 0.349 0.308 -0.261
ENSG00000189091 E038 1682.8059870 0.0002799087 8.897395e-01 9.335317e-01 16 70561630 70561784 155 + 3.200 3.207 0.024
ENSG00000189091 E039 1.9039905 0.1060057384 6.817240e-01 7.853581e-01 16 70563729 70563875 147 + 0.485 0.410 -0.388
ENSG00000189091 E040 1755.3980633 0.0010542014 8.866803e-01 9.315291e-01 16 70563876 70564050 175 + 3.222 3.223 0.004
ENSG00000189091 E041 1897.1074818 0.0003812927 1.702178e-06 1.344700e-05 16 70565065 70565270 206 + 3.213 3.278 0.218
ENSG00000189091 E042 1957.3788103 0.0009335939 5.641538e-03 1.766187e-02 16 70565368 70565524 157 + 3.235 3.287 0.171
ENSG00000189091 E043 1.2305573 0.0893725246 5.822745e-02 1.235913e-01 16 70565525 70565720 196 + 0.541 0.180 -2.272
ENSG00000189091 E044 1766.0191279 0.0015083274 4.773982e-05 2.703155e-04 16 70567411 70567536 126 + 3.164 3.254 0.297
ENSG00000189091 E045 0.8438645 0.0136968632 9.305384e-01 9.603171e-01 16 70567537 70567541 5 + 0.261 0.249 -0.092
ENSG00000189091 E046 2375.4886136 0.0016696116 1.366346e-06 1.101912e-05 16 70568283 70568495 213 + 3.281 3.387 0.352
ENSG00000189091 E047 1773.0661008 0.0022145558 7.152004e-07 6.130331e-06 16 70569043 70569141 99 + 3.139 3.266 0.420
ENSG00000189091 E048 8.1979234 0.0022549920 9.980872e-01 1.000000e+00 16 70569915 70570005 91 + 0.945 0.953 0.027
ENSG00000189091 E049 2054.6558244 0.0022050849 3.548375e-09 4.748722e-08 16 70570006 70570149 144 + 3.189 3.335 0.487
ENSG00000189091 E050 1756.3556271 0.0020692742 4.548078e-12 1.000603e-10 16 70571095 70571199 105 + 3.104 3.273 0.561
ENSG00000189091 E051 5148.9148781 0.0023402327 1.630506e-15 5.997949e-14 16 70571673 70576300 4628 + 3.561 3.742 0.601
ENSG00000189091 E052 16.6189855 0.0010771307 2.430228e-01 3.777419e-01 16 70576301 70576348 48 + 1.151 1.261 0.388
ENSG00000189091 E053 373.3204798 0.0037213865 1.909847e-16 7.929319e-15 16 70576349 70577317 969 + 2.323 2.636 1.041
ENSG00000189091 E054 172.3492242 0.0097064697 8.556421e-11 1.528513e-09 16 70577318 70577670 353 + 1.925 2.316 1.308