ENSG00000189079

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000334344 ENSG00000189079 HEK293_OSMI2_2hA HEK293_TMG_2hB ARID2 protein_coding protein_coding 4.948355 2.234509 7.130749 0.241932 0.2001425 1.669676 2.3381405 0.7126251 3.54743769 0.18637598 0.11575920 2.299519 0.43867500 0.32996667 0.497566667 0.16760000 2.988316e-01 3.073996e-27 FALSE TRUE
ENST00000422737 ENSG00000189079 HEK293_OSMI2_2hA HEK293_TMG_2hB ARID2 protein_coding protein_coding 4.948355 2.234509 7.130749 0.241932 0.2001425 1.669676 1.7319314 0.0000000 3.34411880 0.00000000 0.08905867 8.389790 0.22982917 0.00000000 0.469233333 0.46923333 3.073996e-27 3.073996e-27 FALSE TRUE
ENST00000427628 ENSG00000189079 HEK293_OSMI2_2hA HEK293_TMG_2hB ARID2 protein_coding processed_transcript 4.948355 2.234509 7.130749 0.241932 0.2001425 1.669676 0.1023078 0.2967055 0.00000000 0.16885833 0.00000000 -4.938782 0.04060000 0.11900000 0.000000000 -0.11900000 2.526087e-02 3.073996e-27   FALSE
ENST00000444670 ENSG00000189079 HEK293_OSMI2_2hA HEK293_TMG_2hB ARID2 protein_coding protein_coding 4.948355 2.234509 7.130749 0.241932 0.2001425 1.669676 0.1745378 0.1642372 0.00000000 0.08212688 0.00000000 -4.122981 0.07751667 0.07633333 0.000000000 -0.07633333 3.050016e-02 3.073996e-27 FALSE TRUE
ENST00000457135 ENSG00000189079 HEK293_OSMI2_2hA HEK293_TMG_2hB ARID2 protein_coding protein_coding 4.948355 2.234509 7.130749 0.241932 0.2001425 1.669676 0.4352668 1.0609407 0.05936615 0.16152325 0.03563453 -3.948503 0.18197917 0.47470000 0.008366667 -0.46633333 5.432187e-17 3.073996e-27 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000189079 E001 0.6600838 0.0547414874 1.845410e-01 3.069073e-01 12 45729702 45729705 4 + 0.114 0.382 2.225
ENSG00000189079 E002 0.9567719 0.0422108972 4.400395e-01 5.817579e-01 12 45729706 45729712 7 + 0.205 0.381 1.224
ENSG00000189079 E003 6.7956178 0.0024088326 4.789831e-01 6.173928e-01 12 45729713 45729872 160 + 0.828 0.772 -0.218
ENSG00000189079 E004 6.1324135 0.0026156109 8.565012e-02 1.684320e-01 12 45729873 45729885 13 + 0.818 0.581 -0.987
ENSG00000189079 E005 6.6430436 0.0025376392 5.722817e-01 6.984150e-01 12 45729886 45729915 30 + 0.808 0.773 -0.139
ENSG00000189079 E006 5.7551693 0.0029533364 9.113658e-01 9.477245e-01 12 45729916 45729928 13 + 0.742 0.773 0.124
ENSG00000189079 E007 16.7698316 0.0011589335 2.892916e-02 6.986300e-02 12 45730044 45730137 94 + 1.193 1.006 -0.676
ENSG00000189079 E008 22.4439526 0.0008145463 3.342284e-03 1.126926e-02 12 45731217 45731314 98 + 1.323 1.088 -0.833
ENSG00000189079 E009 0.8814403 0.0140116130 1.149234e-04 5.905476e-04 12 45755931 45756005 75 + 0.000 0.655 14.726
ENSG00000189079 E010 0.2966881 0.0290785164 1.000000e+00   12 45776081 45776329 249 + 0.114 0.000 -11.048
ENSG00000189079 E011 25.7282131 0.0007160981 4.521950e-08 4.920279e-07 12 45811418 45811551 134 + 1.407 0.865 -1.956
ENSG00000189079 E012 37.5530872 0.0007008365 9.745546e-07 8.103693e-06 12 45817670 45817888 219 + 1.548 1.198 -1.217
ENSG00000189079 E013 23.3224614 0.0008078097 4.573871e-03 1.474703e-02 12 45821420 45821487 68 + 1.332 1.112 -0.777
ENSG00000189079 E014 21.9761438 0.0057657280 3.389740e-04 1.536417e-03 12 45836589 45836655 67 + 1.323 0.975 -1.246
ENSG00000189079 E015 17.2275271 0.0010369973 3.641519e-03 1.213116e-02 12 45836741 45836760 20 + 1.218 0.941 -1.004
ENSG00000189079 E016 35.7570765 0.0095738449 4.099735e-03 1.342418e-02 12 45836761 45836944 184 + 1.510 1.301 -0.722
ENSG00000189079 E017 18.2919289 0.0010057843 3.019327e-01 4.437608e-01 12 45836945 45836991 47 + 1.206 1.157 -0.173
ENSG00000189079 E018 22.5994890 0.0008807241 2.111542e-01 3.398773e-01 12 45837321 45837394 74 + 1.294 1.235 -0.207
ENSG00000189079 E019 16.0109349 0.0012088120 2.630163e-01 4.008725e-01 12 45837395 45837417 23 + 1.154 1.088 -0.236
ENSG00000189079 E020 34.1653992 0.0061022617 1.068646e-02 3.042100e-02 12 45837498 45837707 210 + 1.485 1.316 -0.583
ENSG00000189079 E021 16.3133635 0.0011035183 1.738473e-02 4.578673e-02 12 45839329 45839385 57 + 1.189 0.975 -0.777
ENSG00000189079 E022 23.0067596 0.0008279512 2.379610e-03 8.397319e-03 12 45839386 45839496 111 + 1.332 1.088 -0.865
ENSG00000189079 E023 0.4396707 0.0330752706 6.251441e-01 7.413238e-01 12 45839497 45842234 2738 + 0.162 0.000 -11.587
ENSG00000189079 E024 0.0000000       12 45845990 45846072 83 +      
ENSG00000189079 E025 16.8303363 0.0011160743 9.890440e-02 1.888021e-01 12 45846856 45846937 82 + 1.185 1.063 -0.440
ENSG00000189079 E026 23.8866823 0.0007558463 1.893109e-04 9.182577e-04 12 45848836 45848970 135 + 1.356 1.035 -1.140
ENSG00000189079 E027 34.6567873 0.0006528122 5.582396e-08 5.952430e-07 12 45849580 45849776 197 + 1.522 1.088 -1.519
ENSG00000189079 E028 139.1920070 0.0003810844 1.632313e-15 6.003432e-14 12 45850036 45851286 1251 + 2.098 1.827 -0.913
ENSG00000189079 E029 69.6823279 0.0036983464 2.644315e-04 1.234767e-03 12 45851287 45851838 552 + 1.787 1.614 -0.586
ENSG00000189079 E030 67.0333860 0.0004263465 3.299921e-04 1.500805e-03 12 45851839 45852294 456 + 1.766 1.621 -0.493
ENSG00000189079 E031 85.0703589 0.0003430267 8.882006e-01 9.325413e-01 12 45852295 45852896 602 + 1.831 1.894 0.213
ENSG00000189079 E032 38.0823573 0.0006323388 1.906087e-01 3.145254e-01 12 45860801 45860949 149 + 1.465 1.606 0.484
ENSG00000189079 E033 40.1928271 0.0005459573 3.813934e-04 1.702815e-03 12 45891780 45891918 139 + 1.454 1.725 0.924
ENSG00000189079 E034 30.0453715 0.0007289830 2.903473e-03 9.979757e-03 12 45892011 45892042 32 + 1.335 1.598 0.906
ENSG00000189079 E035 35.8133532 0.0005911043 6.663926e-03 2.034816e-02 12 45892043 45892096 54 + 1.418 1.649 0.793
ENSG00000189079 E036 39.8757294 0.0007116319 4.934966e-03 1.574911e-02 12 45893420 45893543 124 + 1.465 1.695 0.784
ENSG00000189079 E037 0.4482035 0.0254294915 6.259489e-01 7.419666e-01 12 45893544 45893629 86 + 0.162 0.000 -11.620
ENSG00000189079 E038 32.7814045 0.0011718009 8.007284e-02 1.596683e-01 12 45893630 45893721 92 + 1.397 1.575 0.611
ENSG00000189079 E039 0.3030308 0.3426856326 1.000000e+00   12 45893722 45893918 197 + 0.115 0.000 -10.257
ENSG00000189079 E040 0.5138669 0.0205889575 5.550581e-01 6.839602e-01 12 45904342 45904398 57 + 0.114 0.232 1.225
ENSG00000189079 E041 223.6580408 0.0045920652 3.879864e-39 1.271676e-36 12 45904934 45908040 3107 + 2.100 2.602 1.676