ENSG00000189042

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000536254 ENSG00000189042 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF567 protein_coding protein_coding 5.377666 2.371272 7.553587 0.2954825 0.1739354 1.667338 0.29250854 0.08148324 0.57901698 0.08148324 0.45831761 2.6867299 0.06423333 0.03340000 0.07533333 0.04193333 8.459844e-01 7.893643e-12 FALSE TRUE
ENST00000588311 ENSG00000189042 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF567 protein_coding protein_coding 5.377666 2.371272 7.553587 0.2954825 0.1739354 1.667338 0.41067977 0.00000000 0.41908522 0.00000000 0.21024431 5.4231923 0.05280000 0.00000000 0.05426667 0.05426667 3.777783e-01 7.893643e-12 FALSE TRUE
ENST00000589264 ENSG00000189042 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF567 protein_coding protein_coding 5.377666 2.371272 7.553587 0.2954825 0.1739354 1.667338 0.70814737 0.93924331 0.46424437 0.30373958 0.33237038 -1.0011473 0.22102500 0.37540000 0.06036667 -0.31503333 1.119466e-01 7.893643e-12   FALSE
ENST00000682579 ENSG00000189042 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF567 protein_coding protein_coding 5.377666 2.371272 7.553587 0.2954825 0.1739354 1.667338 0.08589465 0.17129837 0.00000000 0.17129837 0.00000000 -4.1802941 0.03432500 0.09366667 0.00000000 -0.09366667 6.444453e-01 7.893643e-12 FALSE TRUE
MSTRG.17037.1 ENSG00000189042 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF567 protein_coding   5.377666 2.371272 7.553587 0.2954825 0.1739354 1.667338 1.46430064 0.40895467 2.59318235 0.06707823 0.34973013 2.6354103 0.23703333 0.17080000 0.34530000 0.17450000 5.282246e-02 7.893643e-12 FALSE TRUE
MSTRG.17037.2 ENSG00000189042 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF567 protein_coding   5.377666 2.371272 7.553587 0.2954825 0.1739354 1.667338 0.55294625 0.00000000 1.69103474 0.00000000 0.29617330 7.4102688 0.08432917 0.00000000 0.22330000 0.22330000 4.605964e-09 7.893643e-12 FALSE TRUE
MSTRG.17037.5 ENSG00000189042 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF567 protein_coding   5.377666 2.371272 7.553587 0.2954825 0.1739354 1.667338 0.99513074 0.00000000 1.42394199 0.00000000 0.71665442 7.1638429 0.11840000 0.00000000 0.19070000 0.19070000 3.177303e-01 7.893643e-12 FALSE TRUE
MSTRG.17037.6 ENSG00000189042 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF567 protein_coding   5.377666 2.371272 7.553587 0.2954825 0.1739354 1.667338 0.26299205 0.46414351 0.03267146 0.05390222 0.03267146 -3.4739805 0.08952083 0.19640000 0.00420000 -0.19220000 7.893643e-12 7.893643e-12   FALSE
MSTRG.17037.9 ENSG00000189042 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF567 protein_coding   5.377666 2.371272 7.553587 0.2954825 0.1739354 1.667338 0.23623189 0.22209395 0.20068376 0.15303753 0.01836105 -0.1396298 0.04354167 0.08440000 0.02656667 -0.05783333 5.103185e-01 7.893643e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000189042 E001 0.2944980 0.3710758470 1.000000e+00   19 36687508 36687598 91 + 0.111 0.000 -8.683
ENSG00000189042 E002 0.4545463 0.6135547048 1.000000e+00 1.000000e+00 19 36687599 36687611 13 + 0.159 0.000 -10.728
ENSG00000189042 E003 0.6017953 0.1057530111 5.555567e-01 6.843965e-01 19 36687612 36687612 1 + 0.200 0.000 -11.746
ENSG00000189042 E004 1.1909051 0.0108647759 1.703088e-01 2.885731e-01 19 36687613 36687617 5 + 0.337 0.000 -12.962
ENSG00000189042 E005 3.8745832 0.1844613446 7.355893e-01 8.263275e-01 19 36687618 36687627 10 + 0.579 0.676 0.421
ENSG00000189042 E006 10.7264131 0.0016491599 5.045729e-01 6.404892e-01 19 36687628 36687634 7 + 0.956 1.047 0.333
ENSG00000189042 E007 1.3231889 0.4166257707 3.268992e-01 4.703466e-01 19 36687635 36687643 9 + 0.237 0.571 1.902
ENSG00000189042 E008 2.2161582 0.4908945728 4.206954e-01 5.638849e-01 19 36687644 36687686 43 + 0.336 0.749 1.983
ENSG00000189042 E009 0.8846375 0.6675257514 3.776803e-01 5.219875e-01 19 36689397 36689399 3 + 0.158 0.407 1.825
ENSG00000189042 E010 0.8846375 0.6675257514 3.776803e-01 5.219875e-01 19 36689400 36689400 1 + 0.158 0.407 1.825
ENSG00000189042 E011 17.1896226 0.0011645853 4.952898e-02 1.083323e-01 19 36689401 36689497 97 + 1.119 1.313 0.687
ENSG00000189042 E012 1.5855470 0.0318075511 9.886901e-02 1.887464e-01 19 36689624 36689721 98 + 0.274 0.590 1.721
ENSG00000189042 E013 12.2551140 0.0037150133 3.026440e-01 4.445401e-01 19 36694802 36694876 75 + 0.997 1.125 0.466
ENSG00000189042 E014 0.1515154 0.0423522302 1.000000e+00   19 36703681 36703736 56 + 0.059 0.000 -10.112
ENSG00000189042 E015 0.3686942 0.0276510768 2.528687e-01 3.893024e-01 19 36711240 36712385 1146 + 0.059 0.237 2.310
ENSG00000189042 E016 20.4560356 0.0011127439 9.969621e-02 1.900173e-01 19 36712386 36712439 54 + 1.202 1.356 0.541
ENSG00000189042 E017 21.5154204 0.0009700255 1.627285e-01 2.787128e-01 19 36712440 36712481 42 + 1.225 1.356 0.459
ENSG00000189042 E018 23.7435503 0.0010358462 2.253637e-01 3.568460e-01 19 36712482 36712512 31 + 1.272 1.383 0.388
ENSG00000189042 E019 1.4102740 0.0108167721 6.176932e-01 7.354483e-01 19 36712513 36712732 220 + 0.337 0.237 -0.692
ENSG00000189042 E020 33.4798525 0.0007123477 1.530660e-01 2.658504e-01 19 36712781 36712867 87 + 1.415 1.526 0.381
ENSG00000189042 E021 80.9076452 0.0003834928 1.665453e-08 1.970491e-07 19 36718948 36719667 720 + 1.857 1.571 -0.971
ENSG00000189042 E022 23.4912958 0.0009268149 1.406077e-02 3.836292e-02 19 36719668 36719752 85 + 1.329 1.100 -0.812
ENSG00000189042 E023 94.9548617 0.0003873316 3.674310e-05 2.136678e-04 19 36719753 36720561 809 + 1.911 1.737 -0.587
ENSG00000189042 E024 35.3242048 0.0007654446 1.640075e-02 4.361662e-02 19 36720562 36721365 804 + 1.425 1.595 0.583
ENSG00000189042 E025 4.5492313 0.0632006808 5.246385e-07 4.621342e-06 19 36723189 36723252 64 + 0.336 1.168 3.555
ENSG00000189042 E026 2.5721906 0.1587498913 7.098202e-04 2.934113e-03 19 36723253 36723347 95 + 0.238 0.943 3.413
ENSG00000189042 E027 0.2966881 0.0290785164 1.000000e+00   19 36727093 36727214 122 + 0.111 0.000 -11.128
ENSG00000189042 E028 0.2966881 0.0290785164 1.000000e+00   19 36727523 36727701 179 + 0.111 0.000 -11.128