ENSG00000189007

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000237283 ENSG00000189007 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAT2 protein_coding protein_coding 15.194 7.908317 21.0143 0.4642196 1.786426 1.408792 1.1098017 0.2163930 1.4578226 0.12246290 0.2554699 2.6967761 0.06015833 0.02893333 0.07263333 0.04370000 4.226757e-01 1.666001e-06 FALSE TRUE
ENST00000367593 ENSG00000189007 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAT2 protein_coding processed_transcript 15.194 7.908317 21.0143 0.4642196 1.786426 1.408792 2.4487341 1.4400510 4.0035075 0.35607622 0.4403009 1.4687600 0.17162083 0.17896667 0.18963333 0.01066667 9.064457e-01 1.666001e-06   FALSE
ENST00000606514 ENSG00000189007 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAT2 protein_coding protein_coding 15.194 7.908317 21.0143 0.4642196 1.786426 1.408792 1.0951229 0.9484289 1.5508825 0.09731655 0.3379645 0.7036186 0.08458333 0.11936667 0.07243333 -0.04693333 1.297717e-01 1.666001e-06 FALSE FALSE
MSTRG.29077.1 ENSG00000189007 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAT2 protein_coding   15.194 7.908317 21.0143 0.4642196 1.786426 1.408792 1.0361745 0.4683250 1.5223067 0.23424251 0.5280840 1.6796420 0.06542083 0.05746667 0.07146667 0.01400000 8.410571e-01 1.666001e-06 TRUE TRUE
MSTRG.29077.10 ENSG00000189007 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAT2 protein_coding   15.194 7.908317 21.0143 0.4642196 1.786426 1.408792 0.7508746 0.5861618 0.7543927 0.29311229 0.3855439 0.3586101 0.05290000 0.07193333 0.03373333 -0.03820000 8.741415e-01 1.666001e-06 FALSE TRUE
MSTRG.29077.12 ENSG00000189007 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAT2 protein_coding   15.194 7.908317 21.0143 0.4642196 1.786426 1.408792 0.9933585 0.8821762 0.7641273 0.20598298 0.3852330 -0.2047578 0.06189583 0.11460000 0.03730000 -0.07730000 4.812175e-01 1.666001e-06 FALSE FALSE
MSTRG.29077.13 ENSG00000189007 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAT2 protein_coding   15.194 7.908317 21.0143 0.4642196 1.786426 1.408792 0.4282043 0.0000000 1.1597476 0.00000000 0.2158956 6.8700534 0.02511667 0.00000000 0.05666667 0.05666667 1.666001e-06 1.666001e-06 FALSE FALSE
MSTRG.29077.8 ENSG00000189007 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAT2 protein_coding   15.194 7.908317 21.0143 0.4642196 1.786426 1.408792 4.6581226 2.2890399 6.0490107 0.25150836 0.7657360 1.3980508 0.30402500 0.29326667 0.28586667 -0.00740000 1.000000e+00 1.666001e-06 FALSE TRUE
MSTRG.29077.9 ENSG00000189007 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAT2 protein_coding   15.194 7.908317 21.0143 0.4642196 1.786426 1.408792 1.5402981 0.6448746 2.3052297 0.33073532 0.1887996 1.8218648 0.09634583 0.07946667 0.11300000 0.03353333 7.561549e-01 1.666001e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000189007 E001 2.331242 0.0762585248 0.82144654 0.88742333 6 143417758 143417772 15 - 0.495 0.541 0.221
ENSG00000189007 E002 2.463393 0.0631395072 0.15280731 0.26547018 6 143420734 143420743 10 - 0.600 0.301 -1.579
ENSG00000189007 E003 3.133042 0.0985069417 0.24249455 0.37709409 6 143420744 143420754 11 - 0.665 0.399 -1.266
ENSG00000189007 E004 2.834278 0.1368762110 0.37965514 0.52391431 6 143420755 143420756 2 - 0.623 0.400 -1.083
ENSG00000189007 E005 3.121401 0.0695633910 0.42283653 0.56598187 6 143420757 143420797 41 - 0.644 0.477 -0.770
ENSG00000189007 E006 6.539061 0.0347524054 0.22965513 0.36202830 6 143420798 143420930 133 - 0.916 0.736 -0.702
ENSG00000189007 E007 6.887608 0.1773718270 0.41552364 0.55890226 6 143422544 143422619 76 - 0.915 0.822 -0.358
ENSG00000189007 E008 108.128696 0.0045092497 0.59780036 0.71951389 6 143422832 143424988 2157 - 2.007 2.034 0.092
ENSG00000189007 E009 11.643030 0.0193972003 0.10033599 0.19098881 6 143424989 143425062 74 - 1.145 0.950 -0.712
ENSG00000189007 E010 10.960996 0.0018066815 0.09679459 0.18557912 6 143425063 143425252 190 - 1.110 0.928 -0.670
ENSG00000189007 E011 279.912962 0.0002840200 0.24713567 0.38256534 6 143425253 143428111 2859 - 2.434 2.411 -0.076
ENSG00000189007 E012 61.152264 0.0031417056 0.02755523 0.06712255 6 143428112 143428193 82 - 1.727 1.841 0.386
ENSG00000189007 E013 60.547019 0.0028911326 0.23438871 0.36762110 6 143428194 143428285 92 - 1.744 1.805 0.207
ENSG00000189007 E014 124.214207 0.0002684872 0.50113589 0.63730073 6 143428286 143428506 221 - 2.067 2.090 0.077
ENSG00000189007 E015 80.931420 0.0020898256 0.98889837 0.99707970 6 143428612 143428684 73 - 1.890 1.891 0.001
ENSG00000189007 E016 90.012937 0.0004361869 0.56931275 0.69590343 6 143432505 143432611 107 - 1.942 1.920 -0.072
ENSG00000189007 E017 104.972973 0.0015538782 0.66215260 0.77050492 6 143433831 143433981 151 - 1.994 2.012 0.059
ENSG00000189007 E018 5.537451 0.0103322559 0.17139758 0.29001344 6 143438509 143438585 77 - 0.855 0.652 -0.822
ENSG00000189007 E019 5.130031 0.0518892886 0.90765374 0.94538106 6 143438586 143438589 4 - 0.771 0.742 -0.118
ENSG00000189007 E020 85.090040 0.0003258505 0.82481366 0.88963678 6 143438590 143438694 105 - 1.908 1.918 0.033
ENSG00000189007 E021 3.955588 0.0131343329 0.52938949 0.66218457 6 143441053 143441086 34 - 0.702 0.602 -0.431
ENSG00000189007 E022 4.542621 0.0035605486 0.26653718 0.40475391 6 143441087 143441140 54 - 0.770 0.601 -0.708
ENSG00000189007 E023 3.559923 0.0121428752 0.53309481 0.66533949 6 143441393 143441437 45 - 0.599 0.698 0.424
ENSG00000189007 E024 25.317809 0.0049991006 0.43758577 0.57952726 6 143441438 143441500 63 - 1.372 1.431 0.205
ENSG00000189007 E025 16.714623 0.0011092914 0.30631157 0.44846678 6 143441501 143441506 6 - 1.189 1.278 0.313
ENSG00000189007 E026 53.624214 0.0051585264 0.07037528 0.14397514 6 143441507 143441977 471 - 1.669 1.776 0.361
ENSG00000189007 E027 32.587566 0.0125375788 0.36462552 0.50897891 6 143444557 143444927 371 - 1.523 1.443 -0.274
ENSG00000189007 E028 7.749774 0.0172243578 0.12809930 0.23152098 6 143444928 143444969 42 - 0.988 0.776 -0.812
ENSG00000189007 E029 8.329320 0.0020792862 0.02135329 0.05433164 6 143446835 143446898 64 - 1.032 0.739 -1.124
ENSG00000189007 E030 40.058983 0.0011625893 0.64563918 0.75771110 6 143450563 143450720 158 - 1.603 1.578 -0.085