ENSG00000188994

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000339907 ENSG00000188994 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF292 protein_coding protein_coding 2.85414 0.6838352 4.502485 0.01725067 0.04759804 2.701257 0.09710281 0.06091057 0.00000000 0.06091057 0.00000000 -2.8260007 0.11886250 0.09246667 0.00000000 -0.09246667 0.3970513769 5.381e-07 FALSE TRUE
ENST00000369577 ENSG00000188994 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF292 protein_coding protein_coding 2.85414 0.6838352 4.502485 0.01725067 0.04759804 2.701257 1.97965649 0.13674805 3.32291903 0.08425500 0.10056918 4.5053730 0.49552917 0.19416667 0.73770000 0.54353333 0.0024147601 5.381e-07 FALSE TRUE
ENST00000369578 ENSG00000188994 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF292 protein_coding processed_transcript 2.85414 0.6838352 4.502485 0.01725067 0.04759804 2.701257 0.17171922 0.09995223 0.30425086 0.05066315 0.05870168 1.5150398 0.05584583 0.14326667 0.06773333 -0.07553333 0.4482820818 5.381e-07 FALSE TRUE
ENST00000392985 ENSG00000188994 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF292 protein_coding protein_coding 2.85414 0.6838352 4.502485 0.01725067 0.04759804 2.701257 0.03976401 0.10637848 0.05045886 0.02548306 0.03148006 -0.9447987 0.03509583 0.15486667 0.01116667 -0.14370000 0.0027578698 5.381e-07   FALSE
ENST00000466062 ENSG00000188994 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF292 protein_coding protein_coding 2.85414 0.6838352 4.502485 0.01725067 0.04759804 2.701257 0.34616201 0.00000000 0.82485620 0.00000000 0.02939454 6.3834558 0.07270417 0.00000000 0.18336667 0.18336667 0.0001476164 5.381e-07 FALSE TRUE
ENST00000485016 ENSG00000188994 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF292 protein_coding processed_transcript 2.85414 0.6838352 4.502485 0.01725067 0.04759804 2.701257 0.04341874 0.05223287 0.00000000 0.05223287 0.00000000 -2.6376767 0.05932083 0.07926667 0.00000000 -0.07926667 0.3735302092 5.381e-07   FALSE
ENST00000496806 ENSG00000188994 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF292 protein_coding protein_coding 2.85414 0.6838352 4.502485 0.01725067 0.04759804 2.701257 0.10035117 0.22761304 0.00000000 0.07166865 0.00000000 -4.5705421 0.12851250 0.33603333 0.00000000 -0.33603333 0.0000005381 5.381e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000188994 E001 0.0000000       6 87152833 87152869 37 +      
ENSG00000188994 E002 0.4545463 0.6731032488 1.000000e+00 1.000000e+00 6 87155191 87155221 31 + 0.106 0.000 -8.016
ENSG00000188994 E003 0.4545463 0.6731032488 1.000000e+00 1.000000e+00 6 87155222 87155361 140 + 0.106 0.000 -9.120
ENSG00000188994 E004 0.1515154 0.0431722763 5.830564e-01   6 87155563 87155564 2 + 0.038 0.000 -8.389
ENSG00000188994 E005 0.1515154 0.0431722763 5.830564e-01   6 87155565 87155575 11 + 0.038 0.000 -8.389
ENSG00000188994 E006 1.1844487 0.0829188604 5.394121e-01 6.706702e-01 6 87155576 87155578 3 + 0.238 0.000 -11.028
ENSG00000188994 E007 1.1844487 0.0829188604 5.394121e-01 6.706702e-01 6 87155579 87155580 2 + 0.238 0.000 -11.028
ENSG00000188994 E008 4.4181506 0.0073816998 8.309639e-01 8.940357e-01 6 87155581 87155620 40 + 0.527 0.652 0.560
ENSG00000188994 E009 8.4664610 0.0353344418 7.147483e-01 8.108623e-01 6 87155621 87155759 139 + 0.744 0.902 0.620
ENSG00000188994 E010 1.5029146 0.0158839464 2.080278e-07 1.987806e-06 6 87169674 87170364 691 + 0.038 0.962 6.486
ENSG00000188994 E011 0.0000000       6 87213714 87213737 24 +      
ENSG00000188994 E012 0.0000000       6 87213738 87213865 128 +      
ENSG00000188994 E013 0.0000000       6 87214998 87215142 145 +      
ENSG00000188994 E014 9.5822395 0.0050830056 3.971783e-01 5.409636e-01 6 87215903 87215962 60 + 0.810 0.752 -0.232
ENSG00000188994 E015 8.4315834 0.0019329633 1.918696e-02 4.974294e-02 6 87215963 87216057 95 + 0.785 0.335 -2.133
ENSG00000188994 E016 7.1480562 0.0023074315 8.737409e-01 9.228610e-01 6 87216299 87216377 79 + 0.692 0.752 0.248
ENSG00000188994 E017 9.3571447 0.0018731821 8.917819e-01 9.348980e-01 6 87218596 87218731 136 + 0.785 0.902 0.452
ENSG00000188994 E018 7.6557341 0.0030481596 1.195375e-07 1.197058e-06 6 87222770 87223936 1167 + 0.572 1.341 2.938
ENSG00000188994 E019 5.0951888 0.0031695202 4.798260e-01 6.181596e-01 6 87233325 87233339 15 + 0.593 0.522 -0.326
ENSG00000188994 E020 14.0404117 0.0075964253 7.312699e-02 1.485200e-01 6 87233340 87233523 184 + 0.964 0.752 -0.817
ENSG00000188994 E021 5.7498508 0.0283390593 1.481875e-02 4.008408e-02 6 87233524 87233527 4 + 0.658 0.000 -13.050
ENSG00000188994 E022 12.5259785 0.0018511680 1.114364e-02 3.151126e-02 6 87243475 87243611 137 + 0.928 0.522 -1.683
ENSG00000188994 E023 12.6373152 0.0018963957 1.503157e-03 5.646024e-03 6 87245503 87245644 142 + 0.937 0.335 -2.718
ENSG00000188994 E024 0.0000000       6 87249312 87249466 155 +      
ENSG00000188994 E025 209.5916837 0.0002262056 1.662248e-28 2.454466e-26 6 87254650 87258376 3727 + 2.099 1.655 -1.495
ENSG00000188994 E026 121.3302255 0.0008201819 1.588543e-01 2.736285e-01 6 87258377 87260037 1661 + 1.835 1.871 0.123
ENSG00000188994 E027 15.0194335 0.0128930509 9.727570e-01 9.870160e-01 6 87260038 87260074 37 + 0.968 1.059 0.336
ENSG00000188994 E028 218.4559694 0.0093316538 9.469982e-16 3.586684e-14 6 87260075 87265943 5869 + 2.038 2.448 1.371