ENSG00000188938

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000375412 ENSG00000188938 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM120AOS protein_coding protein_coding 23.17216 21.20935 30.13402 2.167049 0.46873 0.506491 3.066526 2.020933 4.846983 0.1156548 0.1153956 1.25791780 0.12895417 0.09726667 0.16090000 0.06363333 0.007371410 0.00737141 FALSE TRUE
ENST00000423591 ENSG00000188938 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM120AOS protein_coding protein_coding 23.17216 21.20935 30.13402 2.167049 0.46873 0.506491 11.856747 12.785258 13.630383 1.6173079 0.2952002 0.09227499 0.51420000 0.60163333 0.45243333 -0.14920000 0.008486938 0.00737141 FALSE FALSE
ENST00000476484 ENSG00000188938 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM120AOS protein_coding nonsense_mediated_decay 23.17216 21.20935 30.13402 2.167049 0.46873 0.506491 3.738876 3.144814 6.145144 0.9095316 0.2686018 0.96423774 0.15880000 0.14456667 0.20376667 0.05920000 0.496535358 0.00737141 TRUE FALSE
ENST00000479094 ENSG00000188938 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM120AOS protein_coding processed_transcript 23.17216 21.20935 30.13402 2.167049 0.46873 0.506491 1.210694 1.310048 1.537270 0.6601641 0.3450679 0.22913478 0.05408333 0.05853333 0.05103333 -0.00750000 0.929141002 0.00737141 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000188938 E001 6.6386016 0.0027674636 1.247527e-02 3.467688e-02 9 93431441 93432352 912 - 0.707 1.003 1.146
ENSG00000188938 E002 1.2115291 0.0109860919 2.729474e-01 4.119227e-01 9 93432855 93432987 133 - 0.440 0.237 -1.277
ENSG00000188938 E003 0.7782011 0.0156970758 8.601677e-01 9.137952e-01 9 93432988 93433089 102 - 0.274 0.237 -0.277
ENSG00000188938 E004 9.7021664 0.0017978315 8.657345e-01 9.175225e-01 9 93434324 93435331 1008 - 1.027 1.033 0.019
ENSG00000188938 E005 7.8328148 0.0020738025 3.082236e-04 1.413064e-03 9 93435332 93435922 591 - 1.114 0.665 -1.727
ENSG00000188938 E006 3.2774061 0.1096199811 1.806643e-01 3.020217e-01 9 93437022 93437121 100 - 0.754 0.450 -1.361
ENSG00000188938 E007 4.3500922 0.0453211138 8.846281e-02 1.727733e-01 9 93437130 93437234 105 - 0.853 0.548 -1.276
ENSG00000188938 E008 3.2495079 0.0045831757 1.764173e-02 4.636434e-02 9 93437235 93437291 57 - 0.776 0.389 -1.778
ENSG00000188938 E009 1.5479581 0.0091981308 1.164919e-01 2.149449e-01 9 93437292 93437294 3 - 0.524 0.237 -1.691
ENSG00000188938 E010 1.4298538 0.0107384120 1.822346e-01 3.040004e-01 9 93437762 93437762 1 - 0.484 0.237 -1.497
ENSG00000188938 E011 2.3304136 0.0064474794 1.173494e-02 3.290093e-02 9 93437763 93437866 104 - 0.681 0.237 -2.391
ENSG00000188938 E012 5.8294011 0.0051741065 3.645234e-01 5.088710e-01 9 93438627 93438818 192 - 0.888 0.757 -0.513
ENSG00000188938 E013 3.9741353 0.0044223321 2.335378e-01 3.666023e-01 9 93439403 93439500 98 - 0.776 0.591 -0.778
ENSG00000188938 E014 1.5081035 0.0412736014 1.347625e-01 2.407570e-01 9 93439501 93439525 25 - 0.524 0.236 -1.693
ENSG00000188938 E015 3.3426331 0.0062128706 1.193795e-02 3.338266e-02 9 93441260 93441373 114 - 0.797 0.389 -1.862
ENSG00000188938 E016 350.6064795 0.0095307632 1.012573e-06 8.388895e-06 9 93443332 93446493 3162 - 2.651 2.403 -0.825
ENSG00000188938 E017 21.6603745 0.0220175379 3.425096e-01 4.865064e-01 9 93446494 93446524 31 - 1.407 1.285 -0.425
ENSG00000188938 E018 20.2283506 0.0182519584 6.679617e-01 7.750842e-01 9 93446525 93446532 8 - 1.314 1.331 0.062
ENSG00000188938 E019 300.9467108 0.0016737710 1.508390e-06 1.205586e-05 9 93446533 93446904 372 - 2.426 2.539 0.376
ENSG00000188938 E020 118.2694057 0.0007621132 4.180789e-09 5.520583e-08 9 93446905 93446923 19 - 1.982 2.169 0.625
ENSG00000188938 E021 382.8887869 0.0045830274 6.468434e-03 1.984052e-02 9 93446924 93447257 334 - 2.548 2.624 0.255
ENSG00000188938 E022 125.6955550 0.0021024804 1.275542e-01 2.307427e-01 9 93447258 93447267 10 - 2.086 2.127 0.139
ENSG00000188938 E023 382.6452806 0.0002349071 9.644231e-01 9.815889e-01 9 93447268 93447634 367 - 2.596 2.582 -0.047
ENSG00000188938 E024 144.9756739 0.0007185179 1.668960e-02 4.425494e-02 9 93447635 93447697 63 - 2.211 2.123 -0.292
ENSG00000188938 E025 67.7027523 0.0004178643 6.800191e-02 1.400498e-01 9 93448369 93448489 121 - 1.887 1.796 -0.305
ENSG00000188938 E026 0.4355181 0.6178640047 3.626107e-01 5.070191e-01 9 93450475 93450478 4 - 0.272 0.000 -10.222
ENSG00000188938 E027 136.3594613 0.0058162981 8.258428e-01 8.903666e-01 9 93450479 93450587 109 - 2.146 2.135 -0.035
ENSG00000188938 E028 57.7717180 0.0006109260 4.383874e-01 5.802783e-01 9 93450588 93450599 12 - 1.764 1.786 0.076
ENSG00000188938 E029 7.3976608 0.0028049459 2.222240e-02 5.613739e-02 9 93450742 93450944 203 - 0.776 1.033 0.977
ENSG00000188938 E030 22.4779200 0.0015599436 6.726520e-01 7.785369e-01 9 93450945 93451087 143 - 1.360 1.377 0.058
ENSG00000188938 E031 165.4359395 0.0111500351 7.974404e-01 8.707460e-01 9 93451088 93451588 501 - 2.241 2.203 -0.127
ENSG00000188938 E032 11.8742620 0.0539970016 3.768256e-01 5.211408e-01 9 93452147 93452739 593 - 1.050 1.154 0.376
ENSG00000188938 E033 31.7700119 0.0006480387 1.080528e-01 2.026480e-01 9 93452740 93453581 842 - 1.568 1.455 -0.386