ENSG00000188895

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000339569 ENSG00000188895 HEK293_OSMI2_2hA HEK293_TMG_2hB MSL1 protein_coding retained_intron 25.28199 21.30946 26.1124 0.3013012 0.2152354 0.2931167 1.589686 0.5438834 1.864622 0.08046447 0.14747789 1.75894531 0.06026250 0.02556667 0.07133333 0.04576667 0.0001068467 0.0001068467 FALSE  
ENST00000398532 ENSG00000188895 HEK293_OSMI2_2hA HEK293_TMG_2hB MSL1 protein_coding protein_coding 25.28199 21.30946 26.1124 0.3013012 0.2152354 0.2931167 1.535728 1.2332739 1.939759 0.31869425 0.06646454 0.64915188 0.06156667 0.05810000 0.07433333 0.01623333 0.6621703977 0.0001068467 FALSE  
ENST00000577454 ENSG00000188895 HEK293_OSMI2_2hA HEK293_TMG_2hB MSL1 protein_coding protein_coding 25.28199 21.30946 26.1124 0.3013012 0.2152354 0.2931167 9.535776 8.7579278 8.338014 0.23328176 0.21244180 -0.07080285 0.37955000 0.41133333 0.31933333 -0.09200000 0.0139452415 0.0001068467 FALSE  
ENST00000579565 ENSG00000188895 HEK293_OSMI2_2hA HEK293_TMG_2hB MSL1 protein_coding protein_coding 25.28199 21.30946 26.1124 0.3013012 0.2152354 0.2931167 9.073964 9.2438006 9.036659 1.17374757 0.23310224 -0.03266088 0.36091667 0.43250000 0.34606667 -0.08643333 0.3928697835 0.0001068467 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000188895 E001 28.3772756 0.0115611944 5.005057e-01 6.367430e-01 17 40121971 40122572 602 + 1.479 1.449 -0.106
ENSG00000188895 E002 6.5915278 0.0567079169 4.255985e-01 5.685341e-01 17 40122573 40122583 11 + 0.794 0.951 0.602
ENSG00000188895 E003 10.1960239 0.0432765666 9.548135e-01 9.756759e-01 17 40122584 40122613 30 + 1.034 1.058 0.086
ENSG00000188895 E004 40.4250769 0.0323223445 4.460207e-01 5.875735e-01 17 40122614 40122760 147 + 1.637 1.590 -0.159
ENSG00000188895 E005 88.6173638 0.0161795245 5.418852e-01 6.727736e-01 17 40122761 40123096 336 + 1.958 1.941 -0.059
ENSG00000188895 E006 108.8584656 0.0162564131 7.795797e-01 8.582830e-01 17 40123097 40123284 188 + 2.036 2.040 0.016
ENSG00000188895 E007 116.4661807 0.0024662792 2.392357e-01 3.732242e-01 17 40123285 40123380 96 + 2.080 2.058 -0.074
ENSG00000188895 E008 0.3030308 0.3573135687 3.053719e-01   17 40124577 40124861 285 + 0.209 0.000 -10.009
ENSG00000188895 E009 195.7907257 0.0016382242 9.272877e-01 9.582305e-01 17 40126183 40126392 210 + 2.278 2.306 0.093
ENSG00000188895 E010 90.0600044 0.0003309210 8.766267e-01 9.248083e-01 17 40126393 40126406 14 + 1.942 1.974 0.107
ENSG00000188895 E011 1.1426289 0.0112557189 7.648369e-01 8.478064e-01 17 40126407 40126860 454 + 0.348 0.309 -0.245
ENSG00000188895 E012 346.5433893 0.0002438225 2.631853e-01 4.010559e-01 17 40129245 40129627 383 + 2.517 2.565 0.159
ENSG00000188895 E013 161.7864379 0.0033896464 1.618317e-06 1.284342e-05 17 40129628 40129861 234 + 2.089 2.303 0.713
ENSG00000188895 E014 125.0590321 0.0025622386 7.203059e-09 9.111343e-08 17 40129862 40130293 432 + 1.950 2.206 0.857
ENSG00000188895 E015 8.3476994 0.0083401128 8.619256e-05 4.571879e-04 17 40130930 40131000 71 + 1.143 0.682 -1.760
ENSG00000188895 E016 12.6535776 0.0080605647 2.908409e-09 3.957973e-08 17 40131001 40131219 219 + 1.352 0.712 -2.372
ENSG00000188895 E017 7.9970168 0.0081772426 2.023265e-06 1.572455e-05 17 40131220 40131345 126 + 1.162 0.576 -2.289
ENSG00000188895 E018 10.9403853 0.0015224607 1.553786e-07 1.521084e-06 17 40131346 40131536 191 + 1.274 0.739 -1.988
ENSG00000188895 E019 67.4063752 0.0036055400 2.040024e-04 9.810790e-04 17 40131537 40131584 48 + 1.915 1.753 -0.546
ENSG00000188895 E020 4.7978724 0.0593697282 1.541800e-03 5.771147e-03 17 40131780 40131990 211 + 0.969 0.432 -2.284
ENSG00000188895 E021 2.0776335 0.0067438811 7.956052e-04 3.243980e-03 17 40131991 40132033 43 + 0.698 0.129 -3.531
ENSG00000188895 E022 90.5357782 0.0003395872 1.993374e-07 1.910257e-06 17 40132034 40132098 65 + 2.041 1.874 -0.561
ENSG00000188895 E023 95.1683494 0.0003181720 4.889825e-08 5.283236e-07 17 40133042 40133109 68 + 2.064 1.892 -0.576
ENSG00000188895 E024 1.7253960 0.0082239898 1.551696e-01 2.686175e-01 17 40133110 40133533 424 + 0.538 0.309 -1.245
ENSG00000188895 E025 116.5972719 0.0003112913 8.109904e-08 8.384158e-07 17 40133534 40133658 125 + 2.142 1.993 -0.501
ENSG00000188895 E026 86.7702874 0.0002943670 8.257144e-03 2.443403e-02 17 40133827 40133899 73 + 1.980 1.907 -0.245
ENSG00000188895 E027 1016.3200917 0.0028554470 4.908845e-03 1.567631e-02 17 40134279 40136917 2639 + 2.964 3.045 0.268