ENSG00000188786

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373036 ENSG00000188786 HEK293_OSMI2_2hA HEK293_TMG_2hB MTF1 protein_coding protein_coding 3.979372 3.047212 5.625519 0.1262855 0.4253898 0.882332 3.5841017 3.047212 4.069092 0.1262855 0.07454715 0.4160316 0.92332500 1 0.7319667 -0.2680333 2.283886e-08 2.283886e-08 FALSE TRUE
ENST00000468190 ENSG00000188786 HEK293_OSMI2_2hA HEK293_TMG_2hB MTF1 protein_coding processed_transcript 3.979372 3.047212 5.625519 0.1262855 0.4253898 0.882332 0.3152303 0.000000 1.357508 0.0000000 0.42586329 7.0954057 0.05888333 0 0.2318333 0.2318333 2.994717e-06 2.283886e-08 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000188786 E001 423.8803608 0.0003423141 4.697772e-50 2.880190e-47 1 37809574 37813473 3900 - 2.524 2.721 0.656
ENSG00000188786 E002 186.9599537 0.0002226614 4.513541e-02 1.004405e-01 1 37813474 37815566 2093 - 2.301 2.246 -0.185
ENSG00000188786 E003 20.3590593 0.0011376295 3.127267e-01 4.552504e-01 1 37817419 37817482 64 - 1.367 1.283 -0.293
ENSG00000188786 E004 58.9058774 0.0054973989 1.431946e-02 3.895768e-02 1 37822121 37822716 596 - 1.842 1.695 -0.498
ENSG00000188786 E005 22.4431796 0.0058964057 1.009415e-02 2.899410e-02 1 37823710 37823812 103 - 1.466 1.255 -0.736
ENSG00000188786 E006 19.7312685 0.0031555867 2.021991e-01 3.289509e-01 1 37832245 37832322 78 - 1.372 1.265 -0.375
ENSG00000188786 E007 28.7583995 0.0007408015 1.792927e-01 3.002258e-01 1 37835079 37835215 137 - 1.518 1.425 -0.322
ENSG00000188786 E008 18.3778241 0.0010207497 3.006397e-01 4.423746e-01 1 37835671 37835744 74 - 1.328 1.239 -0.313
ENSG00000188786 E009 27.6487291 0.0006895326 7.617270e-05 4.099026e-04 1 37838625 37838756 132 - 1.571 1.299 -0.939
ENSG00000188786 E010 36.0953185 0.0047143488 4.582378e-06 3.290693e-05 1 37839920 37840158 239 - 1.693 1.374 -1.091
ENSG00000188786 E011 23.9573641 0.0025906408 7.918631e-05 4.240332e-04 1 37857251 37857348 98 - 1.522 1.219 -1.052
ENSG00000188786 E012 31.4156918 0.0329523244 1.974790e-03 7.148389e-03 1 37857349 37857499 151 - 1.642 1.307 -1.152
ENSG00000188786 E013 21.7290495 0.0373716601 6.560953e-04 2.738023e-03 1 37857500 37857575 76 - 1.510 1.097 -1.449
ENSG00000188786 E014 24.7141451 0.0259749890 8.866921e-04 3.567672e-03 1 37857576 37857709 134 - 1.547 1.190 -1.239
ENSG00000188786 E015 0.4375944 0.0267875852 1.388819e-01 2.465632e-01 1 37858488 37858539 52 - 0.269 0.000 -10.265
ENSG00000188786 E016 13.3326709 0.0015647772 3.777675e-04 1.688536e-03 1 37859531 37859592 62 - 1.291 0.944 -1.252