ENSG00000188747

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000683555 ENSG00000188747 HEK293_OSMI2_2hA HEK293_TMG_2hB NOXA1 protein_coding protein_coding 4.265294 5.182367 3.028224 0.8556198 0.5295646 -0.7731641 0.1963634 0.03421134 0.2355411 0.03421134 0.02889716 2.4734761 0.05741250 0.00860000 0.08680000 0.07820000 0.01559617 0.01559617 FALSE  
MSTRG.33706.10 ENSG00000188747 HEK293_OSMI2_2hA HEK293_TMG_2hB NOXA1 protein_coding   4.265294 5.182367 3.028224 0.8556198 0.5295646 -0.7731641 0.5002710 0.72505342 0.1490303 0.36261778 0.14903028 -2.2085476 0.10937917 0.16793333 0.03793333 -0.13000000 0.59069483 0.01559617 FALSE  
MSTRG.33706.4 ENSG00000188747 HEK293_OSMI2_2hA HEK293_TMG_2hB NOXA1 protein_coding   4.265294 5.182367 3.028224 0.8556198 0.5295646 -0.7731641 0.3790837 0.32994044 0.4504375 0.32994044 0.25848753 0.4377233 0.07512917 0.04823333 0.13616667 0.08793333 0.57197389 0.01559617 FALSE  
MSTRG.33706.6 ENSG00000188747 HEK293_OSMI2_2hA HEK293_TMG_2hB NOXA1 protein_coding   4.265294 5.182367 3.028224 0.8556198 0.5295646 -0.7731641 1.6450872 2.39303218 1.2711217 0.53534067 0.30085986 -0.9074485 0.39661667 0.45363333 0.41086667 -0.04276667 0.76576237 0.01559617 FALSE  
MSTRG.33706.7 ENSG00000188747 HEK293_OSMI2_2hA HEK293_TMG_2hB NOXA1 protein_coding   4.265294 5.182367 3.028224 0.8556198 0.5295646 -0.7731641 1.1454595 1.11054564 0.8208971 0.17323638 0.03691118 -0.4314598 0.26138333 0.23116667 0.29043333 0.05926667 0.78324962 0.01559617 FALSE  
MSTRG.33706.8 ENSG00000188747 HEK293_OSMI2_2hA HEK293_TMG_2hB NOXA1 protein_coding   4.265294 5.182367 3.028224 0.8556198 0.5295646 -0.7731641 0.1131584 0.35979380 0.0000000 0.35979380 0.00000000 -5.2086491 0.03188750 0.05260000 0.00000000 -0.05260000 0.85285243 0.01559617 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000188747 E001 0.1451727 0.0453317607 0.310321821   9 137423350 137423392 43 + 0.151 0.000 -10.298
ENSG00000188747 E002 0.1451727 0.0453317607 0.310321821   9 137423393 137423394 2 + 0.151 0.000 -10.300
ENSG00000188747 E003 0.9953799 0.0123228920 0.567193390 0.694038264 9 137423395 137423420 26 + 0.351 0.247 -0.698
ENSG00000188747 E004 3.0710363 0.0057916138 0.001981223 0.007168662 9 137423421 137423470 50 + 0.833 0.358 -2.183
ENSG00000188747 E005 5.5820904 0.0875042949 0.107350014 0.201629304 9 137423471 137423549 79 + 0.928 0.676 -0.999
ENSG00000188747 E006 4.9405542 0.0559389750 0.275645616 0.414989749 9 137423550 137423573 24 + 0.833 0.670 -0.657
ENSG00000188747 E007 11.0026218 0.0016295767 0.198259027 0.324040875 9 137423574 137423706 133 + 1.128 0.998 -0.475
ENSG00000188747 E008 14.6077562 0.0013508828 0.308247901 0.450511407 9 137426248 137426330 83 + 1.224 1.131 -0.331
ENSG00000188747 E009 19.9095479 0.0009664864 0.418377418 0.561654394 9 137426521 137426746 226 + 1.245 1.305 0.209
ENSG00000188747 E010 10.3592114 0.0065888401 0.210084997 0.338648235 9 137427921 137428032 112 + 1.101 0.965 -0.499
ENSG00000188747 E011 10.6680052 0.0065484474 0.153196510 0.266020946 9 137428033 137428075 43 + 1.128 0.976 -0.556
ENSG00000188747 E012 11.9235270 0.0101919554 0.109169458 0.204317417 9 137428076 137428141 66 + 1.179 1.011 -0.605
ENSG00000188747 E013 16.1579137 0.0011580767 0.499728618 0.636006338 9 137428882 137429016 135 + 1.245 1.185 -0.213
ENSG00000188747 E014 7.0538726 0.0387774377 0.716911217 0.812441628 9 137429276 137429302 27 + 0.927 0.867 -0.228
ENSG00000188747 E015 12.4703491 0.0058512087 0.572105749 0.698267713 9 137429303 137429383 81 + 1.071 1.123 0.187
ENSG00000188747 E016 13.6782791 0.0014365881 0.828838303 0.892473699 9 137430784 137430843 60 + 1.154 1.131 -0.084
ENSG00000188747 E017 11.7127910 0.0018133112 0.778319343 0.857348733 9 137431075 137431100 26 + 1.101 1.069 -0.114
ENSG00000188747 E018 15.3874772 0.0197095240 0.897686361 0.938682851 9 137431236 137431341 106 + 1.179 1.193 0.048
ENSG00000188747 E019 11.0683077 0.0016468016 0.689491320 0.791365888 9 137433029 137433074 46 + 1.023 1.060 0.136
ENSG00000188747 E020 11.6119591 0.0017695425 0.121254582 0.221713735 9 137433205 137433263 59 + 0.968 1.123 0.564
ENSG00000188747 E021 17.8407803 0.0246531897 0.295862757 0.437008801 9 137433264 137433446 183 + 1.179 1.290 0.393
ENSG00000188747 E022 19.6932573 0.0014716227 0.112676361 0.209457166 9 137433453 137433607 155 + 1.191 1.316 0.441
ENSG00000188747 E023 15.1981165 0.0013308067 0.325317065 0.468753789 9 137433750 137433864 115 + 1.115 1.200 0.303
ENSG00000188747 E024 16.3382646 0.0012198904 0.106034191 0.199664633 9 137433965 137434079 115 + 1.115 1.252 0.488
ENSG00000188747 E025 2.5066264 0.0069121042 0.343381555 0.487427828 9 137434203 137434223 21 + 0.425 0.581 0.759
ENSG00000188747 E026 12.0405657 0.0018952256 0.031098373 0.074098449 9 137434224 137434406 183 + 0.928 1.147 0.804