ENSG00000188735

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000342607 ENSG00000188735 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM120B protein_coding nonsense_mediated_decay 13.62374 18.32777 8.648814 1.414849 0.2127062 -1.082577 0.3604307 0.05691259 0.7550737 0.03040197 0.3780749 3.5152491 0.03532083 0.00290000 0.08523333 0.08233333 2.654869e-01 2.715359e-05 TRUE TRUE
ENST00000449592 ENSG00000188735 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM120B protein_coding protein_coding 13.62374 18.32777 8.648814 1.414849 0.2127062 -1.082577 6.5770523 8.75153756 3.5733843 0.75230935 0.1730385 -1.2898613 0.46891667 0.47683333 0.41423333 -0.06260000 3.589352e-01 2.715359e-05 FALSE TRUE
ENST00000540377 ENSG00000188735 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM120B protein_coding protein_coding 13.62374 18.32777 8.648814 1.414849 0.2127062 -1.082577 2.4299656 3.52976155 1.1609482 0.57568706 0.1798563 -1.5959749 0.17672917 0.19053333 0.13340000 -0.05713333 3.989780e-01 2.715359e-05 FALSE FALSE
ENST00000541467 ENSG00000188735 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM120B protein_coding protein_coding 13.62374 18.32777 8.648814 1.414849 0.2127062 -1.082577 0.9429763 0.90236538 1.0239697 0.17459636 0.1762573 0.1805102 0.07762917 0.04830000 0.11773333 0.06943333 1.131811e-02 2.715359e-05 FALSE TRUE
MSTRG.8198.5 ENSG00000188735 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM120B protein_coding   13.62374 18.32777 8.648814 1.414849 0.2127062 -1.082577 2.0977104 4.13039893 0.7305288 0.30250858 0.1241966 -2.4831419 0.14155000 0.22956667 0.08526667 -0.14430000 3.886698e-03 2.715359e-05 TRUE TRUE
MSTRG.8198.8 ENSG00000188735 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM120B protein_coding   13.62374 18.32777 8.648814 1.414849 0.2127062 -1.082577 0.8427744 0.62232300 1.1660941 0.03344538 0.1743309 0.8952699 0.07165417 0.03436667 0.13593333 0.10156667 2.715359e-05 2.715359e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000188735 E001 0.0000000       12 121712752 121712758 7 +      
ENSG00000188735 E002 0.4439371 0.0215636214 1.503623e-02 4.056982e-02 12 121712759 121712762 4 + 0.390 0.000 -11.794
ENSG00000188735 E003 0.4439371 0.0215636214 1.503623e-02 4.056982e-02 12 121712763 121712764 2 + 0.390 0.000 -14.560
ENSG00000188735 E004 1.7296755 0.0340955016 6.329901e-03 1.948145e-02 12 121712765 121712768 4 + 0.688 0.219 -2.562
ENSG00000188735 E005 2.8389064 0.0904640715 9.117919e-03 2.657849e-02 12 121712769 121712778 10 + 0.834 0.364 -2.150
ENSG00000188735 E006 62.2359774 0.0013341160 2.104519e-01 3.390695e-01 12 121712779 121712964 186 + 1.779 1.729 -0.169
ENSG00000188735 E007 0.9899927 0.0594834779 8.454249e-02 1.666648e-01 12 121743623 121743628 6 + 0.000 0.362 12.862
ENSG00000188735 E008 91.5774125 0.0003697401 5.382463e-02 1.159504e-01 12 121743629 121743747 119 + 1.955 1.891 -0.216
ENSG00000188735 E009 126.8229923 0.0002792077 1.915060e-02 4.966179e-02 12 121748326 121748442 117 + 2.097 2.031 -0.223
ENSG00000188735 E010 109.3264649 0.0003184049 2.581220e-03 9.008095e-03 12 121750380 121750439 60 + 2.057 1.960 -0.323
ENSG00000188735 E011 73.2387046 0.0026372334 6.324488e-02 1.321169e-01 12 121752128 121752128 1 + 1.876 1.797 -0.266
ENSG00000188735 E012 123.1712929 0.0002969144 1.024002e-03 4.041375e-03 12 121752129 121752223 95 + 2.109 2.010 -0.332
ENSG00000188735 E013 106.7005287 0.0003038273 6.651962e-04 2.771485e-03 12 121761649 121761738 90 + 2.057 1.946 -0.372
ENSG00000188735 E014 75.6191031 0.0009178194 9.286995e-03 2.700196e-02 12 121770907 121770972 66 + 1.906 1.803 -0.346
ENSG00000188735 E015 85.0984158 0.0015363894 2.030711e-02 5.212547e-02 12 121771488 121771549 62 + 1.946 1.857 -0.299
ENSG00000188735 E016 114.2700129 0.0003454356 6.438030e-01 7.562551e-01 12 121773421 121773513 93 + 1.984 2.014 0.100
ENSG00000188735 E017 86.3562747 0.0003306448 2.494450e-01 3.852619e-01 12 121774658 121774722 65 + 1.841 1.903 0.208
ENSG00000188735 E018 117.3443289 0.0002907267 9.724720e-01 9.868385e-01 12 121775062 121775130 69 + 2.006 2.020 0.047
ENSG00000188735 E019 287.5531877 0.0002441528 2.693325e-01 4.078543e-01 12 121775609 121776262 654 + 2.374 2.413 0.131
ENSG00000188735 E020 28.4219248 0.0169608142 2.951790e-01 4.363125e-01 12 121776263 121776283 21 + 1.464 1.388 -0.263
ENSG00000188735 E021 41.4323760 0.0025217055 5.860835e-01 7.097129e-01 12 121776284 121776374 91 + 1.583 1.563 -0.070
ENSG00000188735 E022 43.7811343 0.0047485730 6.384831e-01 7.521163e-01 12 121776375 121776444 70 + 1.555 1.603 0.163
ENSG00000188735 E023 91.6785466 0.0003096605 3.893329e-01 5.334387e-01 12 121776445 121776821 377 + 1.873 1.921 0.163
ENSG00000188735 E024 91.0418593 0.0003322530 2.650020e-01 4.030106e-01 12 121776822 121777247 426 + 1.865 1.924 0.199
ENSG00000188735 E025 59.8073801 0.0019161258 6.563092e-02 1.360955e-01 12 121777248 121777392 145 + 1.786 1.704 -0.279
ENSG00000188735 E026 161.4169053 0.0002256540 1.362906e-02 3.737602e-02 12 121777393 121777897 505 + 2.197 2.136 -0.205
ENSG00000188735 E027 72.3738842 0.0120963641 1.048772e-02 2.994957e-02 12 121777898 121778076 179 + 1.924 1.764 -0.538
ENSG00000188735 E028 49.7175217 0.0061917236 2.656289e-03 9.241985e-03 12 121778077 121778127 51 + 1.772 1.596 -0.597
ENSG00000188735 E029 366.0668513 0.0001788059 2.081512e-07 1.988784e-06 12 121778128 121779548 1421 + 2.571 2.483 -0.294
ENSG00000188735 E030 79.2253189 0.0030331544 6.444079e-01 7.567310e-01 12 121779549 121779623 75 + 1.850 1.843 -0.024
ENSG00000188735 E031 140.8011049 0.0033413238 4.146679e-01 5.580683e-01 12 121779624 121780102 479 + 2.055 2.108 0.178
ENSG00000188735 E032 116.4981740 0.0003437543 9.131545e-03 2.661206e-02 12 121780103 121780451 349 + 1.926 2.038 0.375
ENSG00000188735 E033 181.7986889 0.0006916651 1.190073e-06 9.724208e-06 12 121780452 121780940 489 + 2.071 2.244 0.577
ENSG00000188735 E034 123.0621669 0.0003843372 1.433353e-08 1.716138e-07 12 121780941 121781142 202 + 1.856 2.089 0.782
ENSG00000188735 E035 102.7378710 0.0088391867 1.182125e-06 9.668857e-06 12 121781143 121781321 179 + 1.711 2.032 1.084
ENSG00000188735 E036 287.3136692 0.0087561774 2.874736e-07 2.671229e-06 12 121781322 121782031 710 + 2.192 2.468 0.922
ENSG00000188735 E037 51.3059769 0.0169073684 5.360473e-01 6.678133e-01 12 121782032 121783001 970 + 1.620 1.688 0.231