ENSG00000188732

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000344962 ENSG00000188732 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM221A protein_coding protein_coding 4.013896 3.363558 3.706578 0.5253495 0.3622515 0.1397038 0.4755839 1.0385751 0.4109058 0.03582477 0.20188618 -1.3168608 0.1571208 0.3199000 0.11180000 -0.20810000 0.06873035 0.03302394 FALSE  
ENST00000409192 ENSG00000188732 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM221A protein_coding protein_coding 4.013896 3.363558 3.706578 0.5253495 0.3622515 0.1397038 1.4569996 0.4219291 1.7166305 0.31930642 0.22756443 1.9990929 0.3258250 0.1038667 0.45993333 0.35606667 0.05975476 0.03302394 FALSE  
ENST00000409653 ENSG00000188732 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM221A protein_coding protein_coding 4.013896 3.363558 3.706578 0.5253495 0.3622515 0.1397038 1.2830726 0.7899277 1.1246925 0.05143195 0.19442086 0.5043599 0.2919083 0.2414333 0.30550000 0.06406667 0.65888300 0.03302394 FALSE  
ENST00000409994 ENSG00000188732 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM221A protein_coding protein_coding 4.013896 3.363558 3.706578 0.5253495 0.3622515 0.1397038 0.3826968 0.6364777 0.1287268 0.10272797 0.12872675 -2.2203546 0.1030042 0.1922333 0.02980000 -0.16243333 0.07780934 0.03302394 FALSE  
ENST00000483090 ENSG00000188732 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM221A protein_coding processed_transcript 4.013896 3.363558 3.706578 0.5253495 0.3622515 0.1397038 0.2289945 0.3758345 0.0930663 0.03845112 0.04656767 -1.9044093 0.0694875 0.1141667 0.02756667 -0.08660000 0.03302394 0.03302394    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000188732 E001 0.2987644 0.0298790001 1.797332e-01   7 23680130 23680166 37 + 0.228 0.000 -10.679
ENSG00000188732 E002 1.1865370 0.0119054177 1.099582e-01 2.054851e-01 7 23680167 23680178 12 + 0.487 0.208 -1.754
ENSG00000188732 E003 1.7786655 0.1579201660 4.028189e-01 5.466144e-01 7 23680179 23680183 5 + 0.533 0.394 -0.706
ENSG00000188732 E004 3.3975220 0.0228609532 7.677221e-01 8.498956e-01 7 23680184 23680198 15 + 0.681 0.639 -0.179
ENSG00000188732 E005 9.9522553 0.0066054052 2.298154e-01 3.622357e-01 7 23680199 23680283 85 + 1.116 0.994 -0.445
ENSG00000188732 E006 11.1671059 0.0017412747 1.145149e-01 2.121379e-01 7 23684499 23684672 174 + 1.170 1.022 -0.536
ENSG00000188732 E007 0.2998086 0.0280386292 9.450395e-01   7 23686289 23688227 1939 + 0.129 0.116 -0.170
ENSG00000188732 E008 0.0000000       7 23688228 23688323 96 +      
ENSG00000188732 E009 0.2214452 0.0527302613 5.224020e-01   7 23688324 23688987 664 + 0.000 0.117 9.076
ENSG00000188732 E010 22.8942218 0.0009850929 4.639132e-01 6.036773e-01 7 23689269 23689459 191 + 1.412 1.363 -0.169
ENSG00000188732 E011 36.6577245 0.0007144416 5.099606e-01 6.452228e-01 7 23691390 23691596 207 + 1.598 1.563 -0.118
ENSG00000188732 E012 1.5541990 0.0091064955 4.141450e-01 5.575506e-01 7 23692183 23692253 71 + 0.487 0.348 -0.754
ENSG00000188732 E013 7.9894202 0.0028415699 3.462773e-02 8.095015e-02 7 23692254 23694913 2660 + 1.068 0.835 -0.874
ENSG00000188732 E014 16.9182098 0.0013320974 3.204462e-01 4.635766e-01 7 23698192 23698299 108 + 1.209 1.288 0.279
ENSG00000188732 E015 16.6348896 0.0012963713 6.994299e-01 7.991851e-01 7 23700786 23700792 7 + 1.236 1.267 0.109
ENSG00000188732 E016 21.8528037 0.0010240793 8.642231e-01 9.164640e-01 7 23700793 23700868 76 + 1.369 1.358 -0.041
ENSG00000188732 E017 17.2138038 0.0067864746 8.712447e-01 9.212053e-01 7 23702096 23702221 126 + 1.253 1.260 0.025
ENSG00000188732 E018 16.3209480 0.0014321689 1.033727e-05 6.849583e-05 7 23702222 23702650 429 + 0.983 1.364 1.358
ENSG00000188732 E019 3.9081746 0.0045118963 2.926022e-03 1.004705e-02 7 23702694 23703249 556 + 0.376 0.834 2.080