ENSG00000188706

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357166 ENSG00000188706 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC9 protein_coding protein_coding 47.15648 60.74268 34.61286 4.363358 1.332345 -0.8112231 15.971187 27.355436 9.261021 0.4095871 0.3748017 -1.5615547 0.3243542 0.4550333 0.2690000 -0.18603333 1.742259e-03 2.120532e-52 FALSE TRUE
ENST00000371064 ENSG00000188706 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC9 protein_coding protein_coding 47.15648 60.74268 34.61286 4.363358 1.332345 -0.8112231 5.417349 6.875060 4.558912 0.8161876 0.8148183 -0.5916187 0.1127667 0.1139667 0.1304000 0.01643333 8.260269e-01 2.120532e-52 FALSE TRUE
MSTRG.34859.15 ENSG00000188706 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC9 protein_coding   47.15648 60.74268 34.61286 4.363358 1.332345 -0.8112231 4.832231 0.000000 7.211305 0.0000000 0.8830552 9.4961158 0.1185333 0.0000000 0.2071667 0.20716667 2.120532e-52 2.120532e-52 FALSE FALSE
MSTRG.34859.3 ENSG00000188706 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC9 protein_coding   47.15648 60.74268 34.61286 4.363358 1.332345 -0.8112231 8.995727 8.475636 5.627500 2.4380573 0.8963914 -0.5899673 0.1919333 0.1406667 0.1624333 0.02176667 8.335005e-01 2.120532e-52 FALSE TRUE
MSTRG.34859.4 ENSG00000188706 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC9 protein_coding   47.15648 60.74268 34.61286 4.363358 1.332345 -0.8112231 6.772510 7.794803 3.539088 0.8755094 0.8620827 -1.1369140 0.1434167 0.1275333 0.1040000 -0.02353333 7.291868e-01 2.120532e-52 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000188706 E001 1022.393182 0.0064048738 2.828143e-06 2.129166e-05 X 129803288 129805328 2041 - 2.799 3.012 0.709
ENSG00000188706 E002 1938.845347 0.0009334429 4.723760e-15 1.630356e-13 X 129805329 129806486 1158 - 3.128 3.276 0.495
ENSG00000188706 E003 355.109388 0.0013572597 2.795960e-01 4.193575e-01 X 129810905 129810986 82 - 2.495 2.503 0.025
ENSG00000188706 E004 196.854202 0.0010007086 4.916465e-01 6.289313e-01 X 129810987 129811001 15 - 2.238 2.252 0.047
ENSG00000188706 E005 273.937209 0.0002808124 7.711843e-01 8.522742e-01 X 129811406 129811446 41 - 2.360 2.402 0.140
ENSG00000188706 E006 357.555876 0.0001982217 1.949823e-01 3.199630e-01 X 129811447 129811509 63 - 2.499 2.506 0.024
ENSG00000188706 E007 392.410743 0.0020838969 5.574046e-02 1.192450e-01 X 129812718 129812820 103 - 2.559 2.540 -0.064
ENSG00000188706 E008 17.757205 0.0010847586 8.217878e-01 8.876062e-01 X 129813661 129813676 16 - 1.184 1.237 0.186
ENSG00000188706 E009 297.260526 0.0009279557 6.109531e-04 2.573252e-03 X 129813677 129813725 49 - 2.463 2.409 -0.179
ENSG00000188706 E010 392.224864 0.0004662110 1.897422e-03 6.906202e-03 X 129814658 129814770 113 - 2.567 2.536 -0.104
ENSG00000188706 E011 184.096858 0.0010713729 1.154745e-02 3.245982e-02 X 129814771 129814795 25 - 2.248 2.203 -0.151
ENSG00000188706 E012 6.915406 0.0794650725 9.161914e-01 9.510095e-01 X 129822888 129823402 515 - 0.858 0.857 -0.001
ENSG00000188706 E013 331.620915 0.0014804142 6.860249e-02 1.410505e-01 X 129823679 129823837 159 - 2.483 2.468 -0.050
ENSG00000188706 E014 353.210743 0.0015133247 9.583750e-04 3.816156e-03 X 129828981 129829141 161 - 2.539 2.485 -0.180
ENSG00000188706 E015 326.954111 0.0001612123 1.760410e-03 6.472924e-03 X 129841779 129841918 140 - 2.490 2.457 -0.109
ENSG00000188706 E016 163.075043 0.0018483926 2.876241e-03 9.900527e-03 X 129841919 129841930 12 - 2.218 2.147 -0.239
ENSG00000188706 E017 190.972054 0.0013452913 4.910923e-05 2.772476e-04 X 129841931 129841956 26 - 2.302 2.208 -0.316
ENSG00000188706 E018 368.430865 0.0003363356 6.625346e-09 8.446072e-08 X 129841957 129842080 124 - 2.578 2.491 -0.289
ENSG00000188706 E019 299.855130 0.0022381350 7.280290e-06 4.991484e-05 X 129843259 129843326 68 - 2.499 2.397 -0.341
ENSG00000188706 E020 12.851432 0.0264422649 5.580356e-03 1.750156e-02 X 129843327 129843460 134 - 1.291 0.988 -1.087
ENSG00000188706 E021 2.835670 0.0602602143 9.077804e-02 1.763642e-01 X 129843539 129843562 24 - 0.723 0.446 -1.257
ENSG00000188706 E022 4.226837 0.0497375932 2.005567e-01 3.269023e-01 X 129843563 129843695 133 - 0.795 0.617 -0.738
ENSG00000188706 E023 291.504184 0.0028914492 3.829441e-04 1.708651e-03 X 129843696 129843909 214 - 2.473 2.391 -0.273