ENSG00000188681

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000416067 ENSG00000188681 HEK293_OSMI2_2hA HEK293_TMG_2hB TEKT4P2 transcribed_unprocessed_pseudogene processed_transcript 13.19095 17.79708 11.30833 1.24625 0.3895893 -0.65379 5.346681 10.030971 2.461778 0.2438046 0.2872010 -2.0222777 0.3717167 0.5698000 0.2198000 -0.350000000 2.074363e-05 2.190212e-17 FALSE TRUE
ENST00000690389 ENSG00000188681 HEK293_OSMI2_2hA HEK293_TMG_2hB TEKT4P2 transcribed_unprocessed_pseudogene processed_transcript 13.19095 17.79708 11.30833 1.24625 0.3895893 -0.65379 1.424945 1.811350 1.205388 0.4098908 0.2748258 -0.5835921 0.1135500 0.1011000 0.1054667 0.004366667 9.786701e-01 2.190212e-17 FALSE TRUE
ENST00000691834 ENSG00000188681 HEK293_OSMI2_2hA HEK293_TMG_2hB TEKT4P2 transcribed_unprocessed_pseudogene processed_transcript 13.19095 17.79708 11.30833 1.24625 0.3895893 -0.65379 4.229007 2.788512 5.908357 0.4929562 0.2493884 1.0805366 0.3557125 0.1544333 0.5222333 0.367800000 2.190212e-17 2.190212e-17   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000188681 E001 0.0000000       21 9067267 9067440 174 -      
ENSG00000188681 E002 0.0000000       21 9068325 9068345 21 -      
ENSG00000188681 E003 0.0000000       21 9068346 9068350 5 -      
ENSG00000188681 E004 0.0000000       21 9068351 9068353 3 -      
ENSG00000188681 E005 0.0000000       21 9068354 9068355 2 -      
ENSG00000188681 E006 0.5169874 0.020044300 9.505653e-01 9.730504e-01 21 9068356 9068358 3 - 0.172 0.158 -0.148
ENSG00000188681 E007 0.5169874 0.020044300 9.505653e-01 9.730504e-01 21 9068359 9068359 1 - 0.171 0.158 -0.145
ENSG00000188681 E008 1.1101601 0.186935560 4.407163e-01 5.823866e-01 21 9068360 9068361 2 - 0.171 0.357 1.397
ENSG00000188681 E009 1.4067465 0.318421656 4.099775e-01 5.535930e-01 21 9068362 9068368 7 - 0.171 0.424 1.772
ENSG00000188681 E010 3.6638020 0.029078516 6.752708e-01 7.805975e-01 21 9068369 9068369 1 - 0.592 0.669 0.337
ENSG00000188681 E011 5.8759198 0.067307330 7.309245e-01 8.226930e-01 21 9068370 9068372 3 - 0.833 0.799 -0.132
ENSG00000188681 E012 6.1757284 0.076442025 6.409692e-01 7.540764e-01 21 9068373 9068373 1 - 0.863 0.812 -0.198
ENSG00000188681 E013 13.6987270 0.044732528 5.791952e-01 7.041459e-01 21 9068374 9068388 15 - 1.067 1.151 0.306
ENSG00000188681 E014 14.0319468 0.045366890 6.197754e-01 7.370937e-01 21 9068389 9068389 1 - 1.084 1.158 0.264
ENSG00000188681 E015 17.8251392 0.045836857 4.137630e-01 5.571776e-01 21 9068390 9068413 24 - 1.149 1.264 0.408
ENSG00000188681 E016 89.8006210 0.001740521 6.302823e-04 2.644631e-03 21 9068414 9068629 216 - 1.809 1.946 0.460
ENSG00000188681 E017 38.1289631 0.003771998 2.248690e-02 5.669744e-02 21 9068630 9068659 30 - 1.426 1.573 0.506
ENSG00000188681 E018 63.7455525 0.001554607 2.985488e-05 1.777596e-04 21 9068660 9069064 405 - 1.599 1.805 0.699
ENSG00000188681 E019 6.2677268 0.003052692 1.070624e-01 2.012048e-01 21 9069065 9069153 89 - 0.642 0.866 0.905
ENSG00000188681 E020 34.8601938 0.012888452 7.849904e-01 8.621363e-01 21 9069154 9069341 188 - 1.518 1.490 -0.095
ENSG00000188681 E021 36.7528360 0.008164074 5.893702e-01 7.124407e-01 21 9069342 9069444 103 - 1.555 1.509 -0.157
ENSG00000188681 E022 32.9939246 0.003010578 1.257126e-01 2.281661e-01 21 9069445 9069599 155 - 1.554 1.446 -0.371
ENSG00000188681 E023 4.4275294 0.020667573 7.414432e-01 8.306231e-01 21 9069600 9070213 614 - 0.729 0.674 -0.226
ENSG00000188681 E024 14.6667755 0.051397687 2.726898e-01 4.116388e-01 21 9070214 9070436 223 - 1.254 1.097 -0.558
ENSG00000188681 E025 6.9766919 0.096975061 7.588542e-01 8.433485e-01 21 9070437 9070444 8 - 0.891 0.843 -0.185
ENSG00000188681 E026 1.6262171 0.081246377 9.783616e-01 9.906289e-01 21 9071128 9071248 121 - 0.389 0.401 0.063
ENSG00000188681 E027 0.6256415 0.017565877 7.797946e-02 1.562298e-01 21 9071609 9071682 74 - 0.390 0.086 -2.730
ENSG00000188681 E028 6.0453297 0.002829187 1.081456e-01 2.027939e-01 21 9073095 9073609 515 - 0.942 0.731 -0.823
ENSG00000188681 E029 14.3586998 0.091536880 4.754841e-01 6.141948e-01 21 9075115 9075341 227 - 1.217 1.105 -0.400
ENSG00000188681 E030 7.9467758 0.040933257 6.834733e-06 4.718902e-05 21 9076228 9077485 1258 - 1.265 0.630 -2.416
ENSG00000188681 E031 9.1688068 0.002056202 8.860384e-05 4.684695e-04 21 9077486 9077539 54 - 1.217 0.796 -1.560
ENSG00000188681 E032 13.6072690 0.020940576 1.263668e-01 2.290826e-01 21 9077540 9077714 175 - 1.242 1.066 -0.630
ENSG00000188681 E033 0.0000000       21 9087878 9087946 69 -      
ENSG00000188681 E034 3.8730559 0.045875848 1.234398e-02 3.435831e-02 21 9124362 9124421 60 - 0.891 0.477 -1.763
ENSG00000188681 E035 19.7354115 0.007272859 1.236410e-01 2.251407e-01 21 9127489 9127535 47 - 1.367 1.224 -0.498
ENSG00000188681 E036 5.1543375 0.003213964 5.343812e-02 1.152699e-01 21 9127536 9127547 12 - 0.917 0.653 -1.052
ENSG00000188681 E037 1.1405526 0.011372390 1.675352e-01 2.849802e-01 21 9128960 9128979 20 - 0.468 0.219 -1.560
ENSG00000188681 E038 1.2502232 0.133217430 5.738404e-01 6.997537e-01 21 9128980 9129200 221 - 0.389 0.277 -0.702
ENSG00000188681 E039 1.0663419 0.370220503 6.059672e-01 7.262475e-01 21 9129201 9129682 482 - 0.389 0.227 -1.081
ENSG00000188681 E040 4.3635513 0.371745788 4.132090e-01 5.567322e-01 21 9129683 9129686 4 - 0.832 0.608 -0.919
ENSG00000188681 E041 1.9833584 0.364067281 6.121736e-01 7.311689e-01 21 9129687 9129773 87 - 0.533 0.381 -0.781