ENSG00000188647

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340434 ENSG00000188647 HEK293_OSMI2_2hA HEK293_TMG_2hB PTAR1 protein_coding protein_coding 6.09446 1.245081 10.58011 0.2474081 0.3895147 3.076866 2.9366648 0.66446170 5.53221703 0.11148403 0.38277178 3.0386548 0.50319167 0.53970000 0.521666667 -0.01803333 9.355643e-01 3.778338e-08 FALSE TRUE
ENST00000377200 ENSG00000188647 HEK293_OSMI2_2hA HEK293_TMG_2hB PTAR1 protein_coding protein_coding 6.09446 1.245081 10.58011 0.2474081 0.3895147 3.076866 1.0487174 0.03656891 0.97757796 0.03656891 0.06716495 4.4064557 0.15187083 0.03920000 0.092900000 0.05370000 1.193355e-01 3.778338e-08 FALSE TRUE
ENST00000467511 ENSG00000188647 HEK293_OSMI2_2hA HEK293_TMG_2hB PTAR1 protein_coding retained_intron 6.09446 1.245081 10.58011 0.2474081 0.3895147 3.076866 0.2448182 0.13653264 0.05229505 0.08422583 0.05229505 -1.2340325 0.08373750 0.09303333 0.004666667 -0.08836667 1.149355e-01 3.778338e-08 FALSE FALSE
ENST00000472967 ENSG00000188647 HEK293_OSMI2_2hA HEK293_TMG_2hB PTAR1 protein_coding protein_coding 6.09446 1.245081 10.58011 0.2474081 0.3895147 3.076866 0.2974300 0.36255176 0.55364539 0.03565640 0.05734515 0.5973469 0.10109167 0.30216667 0.052166667 -0.25000000 3.778338e-08 3.778338e-08   FALSE
MSTRG.32838.3 ENSG00000188647 HEK293_OSMI2_2hA HEK293_TMG_2hB PTAR1 protein_coding   6.09446 1.245081 10.58011 0.2474081 0.3895147 3.076866 0.2703103 0.00000000 0.57521983 0.00000000 0.32832209 5.8709067 0.02665833 0.00000000 0.055800000 0.05580000 6.051754e-01 3.778338e-08 FALSE TRUE
MSTRG.32838.6 ENSG00000188647 HEK293_OSMI2_2hA HEK293_TMG_2hB PTAR1 protein_coding   6.09446 1.245081 10.58011 0.2474081 0.3895147 3.076866 0.9354971 0.04496577 2.25227640 0.04496577 0.45866439 5.3630980 0.09202083 0.02593333 0.213800000 0.18786667 2.821131e-02 3.778338e-08 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000188647 E001 0.0000000       9 69709522 69709524 3 -      
ENSG00000188647 E002 231.0614123 0.0183068473 9.031977e-19 5.017833e-17 9 69709525 69711546 2022 - 2.050 2.610 1.869
ENSG00000188647 E003 585.4100308 0.0080499646 9.358011e-17 4.045749e-15 9 69711547 69718020 6474 - 2.574 2.362 -0.707
ENSG00000188647 E004 26.8993280 0.0072167331 1.732616e-03 6.385480e-03 9 69718021 69718348 328 - 1.268 0.920 -1.264
ENSG00000188647 E005 39.9744480 0.0005186856 7.882423e-06 5.361751e-05 9 69718349 69718565 217 - 1.436 1.017 -1.482
ENSG00000188647 E006 16.2005117 0.0027889875 1.957228e-03 7.093086e-03 9 69718566 69718568 3 - 1.070 0.616 -1.778
ENSG00000188647 E007 18.2570537 0.0065434798 3.081720e-03 1.050607e-02 9 69718569 69718649 81 - 1.116 0.714 -1.530
ENSG00000188647 E008 20.3350409 0.0012486939 1.302907e-04 6.600933e-04 9 69718650 69718684 35 - 1.164 0.616 -2.117
ENSG00000188647 E009 47.1748617 0.0060225361 7.317627e-05 3.954650e-04 9 69723326 69723630 305 - 1.503 1.163 -1.184
ENSG00000188647 E010 1.1447172 0.0115009899 1.618668e-04 7.999889e-04 9 69731932 69732138 207 - 0.080 0.794 4.685
ENSG00000188647 E011 39.1188258 0.0092178614 3.951879e-01 5.390121e-01 9 69732139 69732352 214 - 1.400 1.397 -0.009
ENSG00000188647 E012 29.6212272 0.0052218160 8.524621e-01 9.085737e-01 9 69734150 69734254 105 - 1.277 1.340 0.218
ENSG00000188647 E013 0.1451727 0.0436154175 6.617559e-01   9 69734255 69734258 4 - 0.042 0.000 -10.516
ENSG00000188647 E014 0.0000000       9 69741516 69741791 276 -      
ENSG00000188647 E015 25.1749614 0.0008575004 7.502609e-01 8.369922e-01 9 69741792 69741858 67 - 1.204 1.319 0.403
ENSG00000188647 E016 33.4283409 0.0006518603 1.977408e-01 3.234060e-01 9 69750781 69750950 170 - 1.338 1.297 -0.145
ENSG00000188647 E017 18.7514110 0.0010631867 4.617385e-19 2.647547e-17 9 69757123 69758704 1582 - 0.892 1.726 2.942
ENSG00000188647 E018 24.3104077 0.0017878260 8.487932e-01 9.061288e-01 9 69759853 69760011 159 - 1.193 1.296 0.363