ENSG00000188610

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355228 ENSG00000188610 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM72B protein_coding protein_coding 14.41456 8.616446 19.55719 1.035317 1.063104 1.181599 0.9551096 1.6360033 0.6775409 0.5894929 0.08923398 -1.259450 0.07313750 0.1814333 0.03506667 -0.1463667 0.001502075 0.001488723 FALSE FALSE
ENST00000369390 ENSG00000188610 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM72B protein_coding protein_coding 14.41456 8.616446 19.55719 1.035317 1.063104 1.181599 9.5947268 6.1996257 13.0916237 0.5245568 0.84538778 1.077167 0.71189167 0.7252667 0.67406667 -0.0512000 0.801609125 0.001488723 FALSE TRUE
ENST00000452190 ENSG00000188610 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM72B protein_coding protein_coding 14.41456 8.616446 19.55719 1.035317 1.063104 1.181599 2.1493232 0.2766513 5.5999097 0.2766513 1.36773869 4.290609 0.11211250 0.0364000 0.28190000 0.2455000 0.058796100 0.001488723 FALSE TRUE
MSTRG.1940.5 ENSG00000188610 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM72B protein_coding   14.41456 8.616446 19.55719 1.035317 1.063104 1.181599 1.0680829 0.0000000 0.0000000 0.0000000 0.00000000 0.000000 0.05894167 0.0000000 0.00000000 0.0000000   0.001488723 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000188610 E001 0.0000000       1 121167646 121167719 74 -      
ENSG00000188610 E002 17.4728591 0.0011718098 5.116140e-01 6.465937e-01 1 121167720 121168231 512 - 1.235 1.288 0.184
ENSG00000188610 E003 85.7009700 0.0003903239 1.297719e-01 2.338421e-01 1 121168232 121168584 353 - 1.911 1.966 0.185
ENSG00000188610 E004 38.7517132 0.0005965239 1.052634e-02 3.003875e-02 1 121168585 121168734 150 - 1.536 1.676 0.476
ENSG00000188610 E005 69.1834090 0.0003857001 3.303922e-01 4.739757e-01 1 121168735 121168835 101 - 1.859 1.818 -0.138
ENSG00000188610 E006 99.2605898 0.0004044043 3.299745e-01 4.735558e-01 1 121177208 121177295 88 - 2.012 1.978 -0.113
ENSG00000188610 E007 65.3399564 0.0005047382 9.509753e-01 9.733348e-01 1 121177296 121177332 37 - 1.817 1.818 0.006
ENSG00000188610 E008 58.6761158 0.0004408941 8.313849e-01 8.943161e-01 1 121181271 121181348 78 - 1.776 1.766 -0.034
ENSG00000188610 E009 0.1482932 0.0411597534 2.706255e-01   1 121182923 121183337 415 - 0.000 0.157 9.419
ENSG00000188610 E010 21.4924723 0.0009518369 3.325357e-01 4.762070e-01 1 121183338 121183353 16 - 1.380 1.307 -0.254
ENSG00000188610 E011 34.5917054 0.0028898083 9.418820e-01 9.674670e-01 1 121183354 121183457 104 - 1.545 1.546 0.003
ENSG00000188610 E012 17.2805071 0.0010960899 8.779224e-02 1.717774e-01 1 121183458 121183469 12 - 1.197 1.334 0.481
ENSG00000188610 E013 88.6688070 0.0023296310 9.824848e-01 9.931021e-01 1 121183470 121183980 511 - 1.948 1.943 -0.018
ENSG00000188610 E014 41.0259166 0.0010290633 1.970282e-02 5.085825e-02 1 121183981 121184074 94 - 1.665 1.530 -0.460
ENSG00000188610 E015 37.3789699 0.0118727063 1.091547e-01 2.043011e-01 1 121184075 121184340 266 - 1.621 1.490 -0.450
ENSG00000188610 E016 4.8293427 0.0035906057 5.737520e-08 6.102723e-07 1 121185318 121185539 222 - 0.294 1.061 3.442