ENSG00000188517

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000399127 ENSG00000188517 HEK293_OSMI2_2hA HEK293_TMG_2hB COL25A1 protein_coding protein_coding 1.667316 0.7265532 2.883085 0.1148792 0.1559604 1.973747 0.08079600 0.09398195 0.0000000 0.05264938 0.00000000 -3.378261 0.07316250 0.12416667 0.00000000 -0.1241667 0.01151187 0.01151187 FALSE TRUE
ENST00000642955 ENSG00000188517 HEK293_OSMI2_2hA HEK293_TMG_2hB COL25A1 protein_coding protein_coding 1.667316 0.7265532 2.883085 0.1148792 0.1559604 1.973747 0.64592688 0.32836142 1.1053536 0.06201434 0.05428923 1.720864 0.41651667 0.45170000 0.38370000 -0.0680000 0.67933703 0.01151187 FALSE TRUE
MSTRG.25295.10 ENSG00000188517 HEK293_OSMI2_2hA HEK293_TMG_2hB COL25A1 protein_coding   1.667316 0.7265532 2.883085 0.1148792 0.1559604 1.973747 0.13437991 0.00000000 0.3182898 0.00000000 0.24748880 5.036898 0.05287083 0.00000000 0.10303333 0.1030333 0.55855106 0.01151187 FALSE TRUE
MSTRG.25295.14 ENSG00000188517 HEK293_OSMI2_2hA HEK293_TMG_2hB COL25A1 protein_coding   1.667316 0.7265532 2.883085 0.1148792 0.1559604 1.973747 0.08949086 0.06619348 0.2735617 0.06619348 0.05580970 1.895923 0.06638333 0.09743333 0.09703333 -0.0004000 0.79856673 0.01151187 FALSE TRUE
MSTRG.25295.4 ENSG00000188517 HEK293_OSMI2_2hA HEK293_TMG_2hB COL25A1 protein_coding   1.667316 0.7265532 2.883085 0.1148792 0.1559604 1.973747 0.09388350 0.00000000 0.4524201 0.00000000 0.25432026 5.531132 0.05137500 0.00000000 0.16740000 0.1674000 0.45057388 0.01151187 TRUE TRUE
MSTRG.25295.6 ENSG00000188517 HEK293_OSMI2_2hA HEK293_TMG_2hB COL25A1 protein_coding   1.667316 0.7265532 2.883085 0.1148792 0.1559604 1.973747 0.38262198 0.16770062 0.4152245 0.01564642 0.20958983 1.258776 0.19945000 0.23996667 0.13743333 -0.1025333 0.68116315 0.01151187 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000188517 E001 41.6854525 0.0006526126 0.017285239 0.04557601 4 108808725 108810720 1996 - 1.547 1.681 0.454
ENSG00000188517 E002 19.9481119 0.0012367381 0.138748190 0.24636561 4 108810721 108811414 694 - 1.311 1.178 -0.468
ENSG00000188517 E003 7.8290290 0.0115015642 0.198220447 0.32398341 4 108811415 108811529 115 - 0.943 0.756 -0.725
ENSG00000188517 E004 24.3161855 0.0007949670 0.410767518 0.55435882 4 108811530 108812020 491 - 1.375 1.309 -0.231
ENSG00000188517 E005 11.6113141 0.0056366043 0.772999785 0.85348716 4 108812021 108812185 165 - 1.052 1.084 0.115
ENSG00000188517 E006 8.4520980 0.0027026502 0.671481858 0.77768744 4 108812186 108812256 71 - 0.915 0.965 0.188
ENSG00000188517 E007 16.1765113 0.0212593121 0.615351220 0.73364659 4 108812257 108812703 447 - 1.173 1.226 0.188
ENSG00000188517 E008 37.6801132 0.0075600398 0.130809466 0.23528118 4 108812704 108813650 947 - 1.567 1.447 -0.413
ENSG00000188517 E009 6.3264115 0.0223199556 0.085192664 0.16772314 4 108813651 108813698 48 - 0.885 0.595 -1.184
ENSG00000188517 E010 6.8861610 0.0121084968 0.185099942 0.30761280 4 108813699 108813736 38 - 0.905 0.708 -0.778
ENSG00000188517 E011 13.3187619 0.0013798469 0.018162909 0.04748046 4 108813737 108813929 193 - 1.173 0.905 -0.980
ENSG00000188517 E012 6.3997268 0.0027176925 0.284700654 0.42494808 4 108817397 108817435 39 - 0.864 0.708 -0.620
ENSG00000188517 E013 0.4439371 0.0215959803 0.496706083 0.63332533 4 108819252 108819329 78 - 0.188 0.000 -9.554
ENSG00000188517 E014 6.9082065 0.0025156335 0.875848360 0.92426764 4 108819812 108819898 87 - 0.853 0.872 0.074
ENSG00000188517 E015 0.8114974 0.0164478379 0.008509546 0.02506192 4 108823876 108824173 298 - 0.072 0.524 3.700
ENSG00000188517 E016 5.8741393 0.0028915934 0.067707458 0.13954954 4 108824174 108824227 54 - 0.727 0.964 0.924
ENSG00000188517 E017 4.5145180 0.0042870398 0.147573297 0.25839034 4 108825196 108825222 27 - 0.628 0.837 0.855
ENSG00000188517 E018 8.2294167 0.0020947698 0.130534700 0.23489848 4 108827135 108827188 54 - 0.864 1.041 0.661
ENSG00000188517 E019 6.6481492 0.0028021470 0.267097325 0.40538460 4 108832380 108832433 54 - 0.795 0.936 0.545
ENSG00000188517 E020 0.6642364 0.0457476856 0.257773797 0.39494753 4 108832434 108832692 259 - 0.134 0.337 1.704
ENSG00000188517 E021 5.4711798 0.0159144821 0.672628418 0.77852647 4 108834355 108834378 24 - 0.782 0.709 -0.295
ENSG00000188517 E022 3.5794960 0.0044020373 0.009359888 0.02718177 4 108834379 108834390 12 - 0.712 0.201 -2.821
ENSG00000188517 E023 2.4400101 0.0060236669 0.885828906 0.93100123 4 108838098 108838178 81 - 0.500 0.525 0.117
ENSG00000188517 E024 6.0872578 0.0027037336 0.603387901 0.72418245 4 108841695 108841721 27 - 0.831 0.756 -0.298
ENSG00000188517 E025 5.8466812 0.0228867307 0.687609416 0.78991546 4 108844519 108844569 51 - 0.781 0.836 0.215
ENSG00000188517 E026 8.6520495 0.0305374661 0.429134380 0.57186624 4 108845189 108845251 63 - 0.914 1.015 0.375
ENSG00000188517 E027 7.5724811 0.0047950989 0.260944920 0.39853624 4 108846139 108846182 44 - 0.853 0.991 0.520
ENSG00000188517 E028 7.3498754 0.0446241258 0.170029914 0.28822944 4 108846183 108846219 37 - 0.819 1.014 0.738
ENSG00000188517 E029 8.1741376 0.0520992305 0.815803726 0.88343428 4 108848759 108848803 45 - 0.915 0.934 0.071
ENSG00000188517 E030 9.0191254 0.0470635653 0.394000506 0.53790763 4 108852236 108852280 45 - 0.993 0.836 -0.593
ENSG00000188517 E031 1.6961506 0.0534490681 0.766378692 0.84890951 4 108852902 108852925 24 - 0.388 0.441 0.285
ENSG00000188517 E032 9.8986057 0.0144829258 0.384677100 0.52883646 4 108859656 108859733 78 - 1.024 0.905 -0.443
ENSG00000188517 E033 5.1585974 0.0035462340 0.688446346 0.79056884 4 108860927 108860971 45 - 0.741 0.798 0.228
ENSG00000188517 E034 0.2934659 0.0281501390 0.385393315   4 108862501 108862545 45 - 0.072 0.200 1.701
ENSG00000188517 E035 9.5767716 0.0020078911 0.886183073 0.93120299 4 108863319 108863387 69 - 0.977 0.991 0.055
ENSG00000188517 E036 7.3365757 0.0044052233 0.506086704 0.64177014 4 108869088 108869150 63 - 0.853 0.936 0.316
ENSG00000188517 E037 0.9619818 0.0272977274 0.166796579 0.28401143 4 108884178 108884222 45 - 0.188 0.441 1.701
ENSG00000188517 E038 7.6187670 0.0022616206 0.616108718 0.73422626 4 108889221 108889256 36 - 0.875 0.936 0.233
ENSG00000188517 E039 7.3210348 0.0023210631 0.736827760 0.82718906 4 108889701 108889733 33 - 0.864 0.906 0.158
ENSG00000188517 E040 8.4107770 0.0023302623 0.200454495 0.32678855 4 108896667 108896711 45 - 0.968 0.798 -0.651
ENSG00000188517 E041 7.9207563 0.0022142096 0.282979922 0.42304297 4 108899154 108899180 27 - 0.942 0.798 -0.554
ENSG00000188517 E042 9.4395801 0.0025673631 0.930710306 0.96039716 4 108901119 108901172 54 - 0.977 0.965 -0.045
ENSG00000188517 E043 7.0902270 0.0026694377 0.785223239 0.86231131 4 108918172 108918216 45 - 0.875 0.837 -0.145
ENSG00000188517 E044 6.3454491 0.0203008582 0.886489713 0.93140122 4 108920578 108920604 27 - 0.819 0.837 0.070
ENSG00000188517 E045 6.1175448 0.0064934648 0.306850860 0.44903298 4 108937808 108937843 36 - 0.769 0.905 0.533
ENSG00000188517 E046 10.2955597 0.0025669786 0.039221773 0.08959254 4 108940539 108940646 108 - 0.942 1.161 0.799
ENSG00000188517 E047 1.1501176 0.0151204632 0.751164281 0.83768436 4 108941366 108941437 72 - 0.279 0.338 0.382
ENSG00000188517 E048 6.3955200 0.0046954515 0.030056311 0.07206781 4 108942209 108942268 60 - 0.741 1.016 1.057
ENSG00000188517 E049 5.8700884 0.0030546720 0.258885226 0.39621141 4 108974367 108974393 27 - 0.755 0.905 0.586
ENSG00000188517 E050 5.3648310 0.0042147765 0.627085818 0.74293309 4 108974533 108974559 27 - 0.782 0.708 -0.298
ENSG00000188517 E051 3.1064115 0.0051085402 0.714841641 0.81092577 4 109010358 109010375 18 - 0.589 0.525 -0.297
ENSG00000188517 E052 3.3045872 0.0243243023 0.324709817 0.46812804 4 109048168 109048175 8 - 0.547 0.708 0.704
ENSG00000188517 E053 6.0237819 0.0028056383 0.750549799 0.83719866 4 109050135 109050179 45 - 0.795 0.837 0.166
ENSG00000188517 E054 7.4725491 0.0023458271 0.366127624 0.51045974 4 109300583 109300652 70 - 0.853 0.965 0.422
ENSG00000188517 E055 8.7592695 0.0026754819 0.727067791 0.81991507 4 109301723 109301808 86 - 0.951 0.906 -0.171
ENSG00000188517 E056 14.0562310 0.0329209896 0.961653505 0.97985441 4 109301809 109302075 267 - 1.129 1.110 -0.068
ENSG00000188517 E057 4.5727084 0.0037315745 0.351678164 0.49590893 4 109302076 109302168 93 - 0.663 0.798 0.551
ENSG00000188517 E058 6.9750289 0.0028712109 0.870788066 0.92096171 4 109302169 109302302 134 - 0.853 0.873 0.075
ENSG00000188517 E059 8.5188117 0.0022077789 0.090121317 0.17531126 4 109302303 109302473 171 - 0.985 0.756 -0.882
ENSG00000188517 E060 5.3594092 0.0030416917 0.017812677 0.04673515 4 109302474 109302496 23 - 0.842 0.441 -1.757
ENSG00000188517 E061 9.3947086 0.0018514218 0.005145640 0.01632546 4 109302497 109302752 256 - 1.045 0.655 -1.520
ENSG00000188517 E062 0.2987644 0.0270923387 0.857385604   4 109302868 109302885 18 - 0.134 0.000 -9.006