ENSG00000188493

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378313 ENSG00000188493 HEK293_OSMI2_2hA HEK293_TMG_2hB C19orf54 protein_coding protein_coding 23.26612 34.24315 18.71659 1.564943 0.7058717 -0.8711485 11.508059 16.316603 9.489309 1.1335536 0.1316221 -0.7813301 0.50263333 0.4754333 0.50790000 0.032466667 0.588852593 0.004244544 FALSE  
ENST00000470681 ENSG00000188493 HEK293_OSMI2_2hA HEK293_TMG_2hB C19orf54 protein_coding protein_coding 23.26612 34.24315 18.71659 1.564943 0.7058717 -0.8711485 4.352746 7.919051 2.592958 0.3179966 0.1065534 -1.6069959 0.17343750 0.2325000 0.13936667 -0.093133333 0.005810298 0.004244544 FALSE  
MSTRG.17182.26 ENSG00000188493 HEK293_OSMI2_2hA HEK293_TMG_2hB C19orf54 protein_coding   23.26612 34.24315 18.71659 1.564943 0.7058717 -0.8711485 1.223926 2.104338 1.167055 0.4496818 0.1302447 -0.8450246 0.05078333 0.0606000 0.06203333 0.001433333 0.965383265 0.004244544 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000188493 E001 1.851914 0.1959333164 2.689987e-01 4.074631e-01 19 40740856 40740860 5 - 0.183 0.456 1.829
ENSG00000188493 E002 2.551650 0.0597819291 7.020149e-02 1.436950e-01 19 40740861 40740861 1 - 0.182 0.562 2.343
ENSG00000188493 E003 6.860044 0.0034319980 7.178471e-01 8.131180e-01 19 40740862 40740864 3 - 0.794 0.838 0.174
ENSG00000188493 E004 24.592061 0.0008113554 8.647455e-03 2.540253e-02 19 40740865 40740882 18 - 1.164 1.383 0.769
ENSG00000188493 E005 87.811698 0.0002997075 4.108162e-03 1.344596e-02 19 40740883 40740934 52 - 1.786 1.908 0.413
ENSG00000188493 E006 111.891832 0.0002654549 7.677187e-04 3.142314e-03 19 40740935 40740962 28 - 1.885 2.013 0.431
ENSG00000188493 E007 94.751448 0.0007612151 4.641960e-04 2.022831e-03 19 40740963 40740965 3 - 1.797 1.948 0.511
ENSG00000188493 E008 100.922903 0.0022957425 2.560934e-04 1.200657e-03 19 40740966 40740969 4 - 1.807 1.979 0.580
ENSG00000188493 E009 95.594454 0.0024144217 2.192492e-04 1.046329e-03 19 40740970 40740973 4 - 1.778 1.958 0.605
ENSG00000188493 E010 104.401038 0.0026039020 1.539968e-03 5.766002e-03 19 40740974 40740981 8 - 1.841 1.989 0.499
ENSG00000188493 E011 144.748813 0.0006859886 1.571647e-04 7.791487e-04 19 40740982 40741008 27 - 1.992 2.125 0.448
ENSG00000188493 E012 174.938324 0.0016174561 3.130113e-05 1.854138e-04 19 40741009 40741065 57 - 2.060 2.211 0.505
ENSG00000188493 E013 163.493549 0.0043517485 1.219353e-04 6.227163e-04 19 40741066 40741119 54 - 2.010 2.185 0.587
ENSG00000188493 E014 102.492092 0.0019843350 1.413236e-04 7.092839e-04 19 40741120 40741121 2 - 1.807 1.983 0.591
ENSG00000188493 E015 101.863406 0.0039286244 1.280508e-03 4.911987e-03 19 40741122 40741123 2 - 1.814 1.978 0.552
ENSG00000188493 E016 124.976404 0.0017269485 2.929524e-04 1.351030e-03 19 40741124 40741140 17 - 1.913 2.063 0.503
ENSG00000188493 E017 199.714437 0.0011269952 5.362294e-08 5.741652e-07 19 40741141 40741222 82 - 2.092 2.273 0.606
ENSG00000188493 E018 268.089551 0.0034580567 7.249718e-06 4.972979e-05 19 40741223 40741365 143 - 2.232 2.400 0.561
ENSG00000188493 E019 191.812958 0.0011509233 8.996011e-06 6.045216e-05 19 40741366 40741439 74 - 2.103 2.251 0.494
ENSG00000188493 E020 251.777009 0.0033153406 6.327684e-02 1.321677e-01 19 40741440 40741691 252 - 2.288 2.352 0.215
ENSG00000188493 E021 75.852661 0.0041633112 8.993664e-01 9.397914e-01 19 40741692 40741693 2 - 1.821 1.823 0.006
ENSG00000188493 E022 183.227660 0.0003050616 4.116786e-01 5.552245e-01 19 40741694 40741790 97 - 2.221 2.191 -0.100
ENSG00000188493 E023 105.006526 0.0002842107 2.574973e-01 3.946164e-01 19 40741791 40741821 31 - 1.994 1.945 -0.165
ENSG00000188493 E024 121.890942 0.0002519077 6.354105e-01 7.497207e-01 19 40741822 40741864 43 - 2.038 2.015 -0.076
ENSG00000188493 E025 213.777809 0.0003134959 1.116739e-03 4.359246e-03 19 40741865 40742072 208 - 2.333 2.238 -0.314
ENSG00000188493 E026 155.208329 0.0008178217 1.405341e-03 5.323902e-03 19 40742073 40742189 117 - 2.206 2.095 -0.373
ENSG00000188493 E027 166.812298 0.0004634748 1.373499e-04 6.918699e-04 19 40742190 40742398 209 - 2.244 2.121 -0.412
ENSG00000188493 E028 120.916220 0.0024778162 1.029309e-01 1.949351e-01 19 40742399 40742514 116 - 2.070 1.996 -0.248
ENSG00000188493 E029 63.331594 0.0004022166 9.104279e-01 9.470351e-01 19 40742515 40742516 2 - 1.747 1.735 -0.038
ENSG00000188493 E030 122.030098 0.0013517151 6.897756e-01 7.915966e-01 19 40742517 40742576 60 - 2.036 2.014 -0.072
ENSG00000188493 E031 214.201886 0.0024264060 2.051851e-01 3.326434e-01 19 40742577 40742770 194 - 2.300 2.251 -0.164
ENSG00000188493 E032 71.735154 0.0013669495 6.088856e-01 7.284777e-01 19 40743905 40743914 10 - 1.814 1.784 -0.104
ENSG00000188493 E033 159.308278 0.0002423897 7.376912e-04 3.034763e-03 19 40743915 40743975 61 - 2.217 2.108 -0.366
ENSG00000188493 E034 45.935997 0.0005192220 2.256184e-06 1.734970e-05 19 40743976 40743981 6 - 1.786 1.525 -0.887
ENSG00000188493 E035 103.123846 0.0003149204 8.648066e-01 9.168650e-01 19 40744067 40744196 130 - 1.958 1.946 -0.041
ENSG00000188493 E036 183.277772 0.0002314858 4.471903e-06 3.219536e-05 19 40744559 40744683 125 - 2.295 2.159 -0.456
ENSG00000188493 E037 7.441610 0.0024023865 1.365957e-02 3.745029e-02 19 40744944 40745129 186 - 1.078 0.783 -1.113
ENSG00000188493 E038 135.710650 0.0033834005 4.193173e-04 1.848437e-03 19 40745130 40745198 69 - 2.178 2.023 -0.520
ENSG00000188493 E039 198.287892 0.0028126655 5.117570e-05 2.876623e-04 19 40749481 40749607 127 - 2.340 2.187 -0.509
ENSG00000188493 E040 361.434359 0.0035199063 4.573496e-08 4.971512e-07 19 40749608 40750284 677 - 2.624 2.438 -0.620
ENSG00000188493 E041 174.382528 0.0037895415 6.656602e-10 1.020616e-08 19 40750285 40750553 269 - 2.350 2.098 -0.842
ENSG00000188493 E042 8.094419 0.0024983109 1.509514e-02 4.070035e-02 19 40751393 40751553 161 - 1.096 0.811 -1.068