ENSG00000188419

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357749 ENSG00000188419 HEK293_OSMI2_2hA HEK293_TMG_2hB CHM protein_coding protein_coding 5.655557 1.343631 9.789426 0.1897369 0.3229184 2.855862 4.4141521 0.4226168 7.70755496 0.09897509 0.26933808 4.156982 0.6788375 0.3447667 0.787233333 0.4424667 2.286392e-03 8.050875e-07 FALSE TRUE
ENST00000467744 ENSG00000188419 HEK293_OSMI2_2hA HEK293_TMG_2hB CHM protein_coding processed_transcript 5.655557 1.343631 9.789426 0.1897369 0.3229184 2.855862 0.1247117 0.4261002 0.05108874 0.16062702 0.03161009 -2.835681 0.0837250 0.2990000 0.005133333 -0.2938667 8.050875e-07 8.050875e-07 FALSE TRUE
ENST00000615443 ENSG00000188419 HEK293_OSMI2_2hA HEK293_TMG_2hB CHM protein_coding protein_coding 5.655557 1.343631 9.789426 0.1897369 0.3229184 2.855862 1.0654176 0.4194825 2.03078254 0.06229531 0.07128167 2.248451 0.2258667 0.3123333 0.207566667 -0.1047667 1.171249e-01 8.050875e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000188419 E001 0.000000       X 85861180 85861180 1 -      
ENSG00000188419 E002 168.379633 0.0002705174 6.208511e-19 3.506809e-17 X 85861181 85863094 1914 - 1.962 2.270 1.030
ENSG00000188419 E003 186.690388 0.0003410353 2.662071e-04 1.241957e-03 X 85863095 85864821 1727 - 2.059 1.890 -0.565
ENSG00000188419 E004 40.019165 0.0055743993 5.514152e-03 1.732306e-02 X 85873052 85873212 161 - 1.412 1.078 -1.179
ENSG00000188419 E005 27.323462 0.0144769741 1.339301e-02 3.682855e-02 X 85878965 85879063 99 - 1.258 0.880 -1.377
ENSG00000188419 E006 33.433023 0.0068922760 2.261457e-01 3.577815e-01 X 85894188 85894284 97 - 1.327 1.184 -0.504
ENSG00000188419 E007 31.708810 0.0033884903 2.940024e-01 4.350785e-01 X 85900646 85900709 64 - 1.304 1.183 -0.428
ENSG00000188419 E008 35.463543 0.0045850447 7.580360e-02 1.527855e-01 X 85901084 85901188 105 - 1.357 1.150 -0.728
ENSG00000188419 E009 24.969899 0.0120280797 9.949483e-03 2.863632e-02 X 85911261 85911338 78 - 1.222 0.811 -1.518
ENSG00000188419 E010 31.314636 0.0041509260 3.270212e-02 7.720435e-02 X 85956153 85956378 226 - 1.309 1.036 -0.973
ENSG00000188419 E011 20.324559 0.0095556031 1.103006e-01 2.059887e-01 X 85957855 85957975 121 - 1.130 0.880 -0.922
ENSG00000188419 E012 23.556579 0.0069389349 3.706619e-02 8.559543e-02 X 85958861 85958977 117 - 1.193 0.880 -1.151
ENSG00000188419 E013 51.301686 0.0064773997 5.187546e-03 1.643860e-02 X 85963665 85964052 388 - 1.516 1.214 -1.049
ENSG00000188419 E014 69.692807 0.0005047382 2.171044e-19 1.297879e-17 X 85969087 85971586 2500 - 1.553 2.026 1.598
ENSG00000188419 E015 0.596395 0.3062161030 8.517320e-03 2.508053e-02 X 85978656 85978766 111 - 0.040 0.618 5.018
ENSG00000188419 E016 41.430385 0.0024617795 4.758270e-02 1.048820e-01 X 85978767 85978891 125 - 1.424 1.213 -0.736
ENSG00000188419 E017 41.730295 0.0020744753 2.283955e-02 5.741043e-02 X 85981737 85981809 73 - 1.428 1.183 -0.859
ENSG00000188419 E018 0.000000       X 86026958 86027490 533 -      
ENSG00000188419 E019 35.410892 0.0033125730 7.815536e-03 2.331737e-02 X 86027491 86027557 67 - 1.364 1.036 -1.168
ENSG00000188419 E020 1.517668 0.0485982824 8.268034e-01 8.910473e-01 X 86047247 86047483 237 - 0.272 0.321 0.332
ENSG00000188419 E021 26.907678 0.0018150223 1.888337e-01 3.122893e-01 X 86047484 86047561 78 - 1.242 1.077 -0.586