ENSG00000188343

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000518322 ENSG00000188343 HEK293_OSMI2_2hA HEK293_TMG_2hB CIBAR1 protein_coding protein_coding 24.62184 7.281754 44.44691 0.4290064 1.574393 2.60807 1.358677 0.6212219 2.401935 0.08393382 0.3578084 1.933972 0.05696250 0.08470000 0.05426667 -0.03043333 2.954423e-01 3.558189e-25 FALSE TRUE
ENST00000518829 ENSG00000188343 HEK293_OSMI2_2hA HEK293_TMG_2hB CIBAR1 protein_coding protein_coding 24.62184 7.281754 44.44691 0.4290064 1.574393 2.60807 12.628497 4.4705597 22.275564 0.03553470 0.8482440 2.314359 0.50975833 0.61756667 0.50240000 -0.11516667 1.391925e-01 3.558189e-25 FALSE FALSE
ENST00000519679 ENSG00000188343 HEK293_OSMI2_2hA HEK293_TMG_2hB CIBAR1 protein_coding protein_coding 24.62184 7.281754 44.44691 0.4290064 1.574393 2.60807 4.477217 0.7336467 7.214592 0.45420305 0.7445185 3.280227 0.18343333 0.09646667 0.16163333 0.06516667 6.593482e-01 3.558189e-25 FALSE TRUE
ENST00000522324 ENSG00000188343 HEK293_OSMI2_2hA HEK293_TMG_2hB CIBAR1 protein_coding protein_coding 24.62184 7.281754 44.44691 0.4290064 1.574393 2.60807 1.602198 0.9537848 1.953621 0.19540894 0.1325339 1.026734 0.09791667 0.13156667 0.04413333 -0.08743333 1.063878e-03 3.558189e-25 FALSE TRUE
ENST00000522803 ENSG00000188343 HEK293_OSMI2_2hA HEK293_TMG_2hB CIBAR1 protein_coding protein_coding 24.62184 7.281754 44.44691 0.4290064 1.574393 2.60807 3.168288 0.0000000 8.211091 0.00000000 0.6583610 9.683186 0.07983333 0.00000000 0.18443333 0.18443333 3.558189e-25 3.558189e-25 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000188343 E001 0.1515154 0.0437421140 1.00000000   8 93698561 93698747 187 + 0.065 0.000 -7.934
ENSG00000188343 E002 1.6264232 0.0082365138 0.05395255 0.11618506 8 93700252 93700288 37 + 0.445 0.000 -13.283
ENSG00000188343 E003 2.0295728 0.0071844882 0.67366661 0.77929827 8 93700507 93700544 38 + 0.445 0.362 -0.456
ENSG00000188343 E004 3.8343644 0.0041414274 0.61249604 0.73142090 8 93700545 93700549 5 + 0.645 0.557 -0.389
ENSG00000188343 E005 4.2740351 0.0036970877 0.43639987 0.57848275 8 93700550 93700552 3 + 0.690 0.557 -0.582
ENSG00000188343 E006 6.2302404 0.0042522076 0.93650763 0.96407412 8 93700553 93700561 9 + 0.804 0.793 -0.042
ENSG00000188343 E007 8.0530280 0.0036439192 0.89813231 0.93899368 8 93700562 93700570 9 + 0.894 0.912 0.069
ENSG00000188343 E008 12.9290860 0.0013573827 0.58441671 0.70836022 8 93700571 93700581 11 + 1.093 1.032 -0.220
ENSG00000188343 E009 16.0571682 0.0011571132 0.58917306 0.71225205 8 93700582 93700593 12 + 1.180 1.126 -0.193
ENSG00000188343 E010 27.6931645 0.0008107545 0.79479230 0.86891513 8 93700594 93700613 20 + 1.396 1.376 -0.068
ENSG00000188343 E011 56.3533727 0.0004091512 0.11382050 0.21108900 8 93700614 93700666 53 + 1.707 1.617 -0.305
ENSG00000188343 E012 50.8743681 0.0005054699 0.05112242 0.11116964 8 93700667 93700668 2 + 1.669 1.550 -0.404
ENSG00000188343 E013 52.1913040 0.0004580159 0.02879086 0.06958223 8 93700669 93700673 5 + 1.683 1.550 -0.450
ENSG00000188343 E014 1.0654260 0.1131156779 0.76460077 0.84762615 8 93700674 93700723 50 + 0.295 0.218 -0.579
ENSG00000188343 E015 0.5806908 0.7903200424 1.00000000 1.00000000 8 93700724 93701057 334 + 0.216 0.000 -10.770
ENSG00000188343 E016 159.7130363 0.0002415780 0.21298376 0.34204907 8 93701224 93701458 235 + 2.143 2.103 -0.133
ENSG00000188343 E017 0.9683114 0.0149912896 0.10693411 0.20100956 8 93701459 93701533 75 + 0.173 0.470 2.001
ENSG00000188343 E018 0.1472490 0.0450683615 1.00000000   8 93701534 93701600 67 + 0.065 0.000 -9.859
ENSG00000188343 E019 0.4375944 0.0257278529 0.62270823 0.73944661 8 93701601 93702164 564 + 0.172 0.000 -11.504
ENSG00000188343 E020 0.1451727 0.0431728335 1.00000000   8 93702165 93702383 219 + 0.065 0.000 -9.870
ENSG00000188343 E021 0.0000000       8 93702384 93702519 136 +      
ENSG00000188343 E022 0.2966881 0.0269209921 1.00000000   8 93702520 93702543 24 + 0.122 0.000 -10.942
ENSG00000188343 E023 111.7399791 0.0005840400 0.50072080 0.63695062 8 93703620 93703688 69 + 1.973 2.000 0.091
ENSG00000188343 E024 115.4559627 0.0013711060 0.71729529 0.81272617 8 93704909 93705010 102 + 1.989 2.003 0.049
ENSG00000188343 E025 14.8172135 0.0012121142 0.00420876 0.01372802 8 93705011 93705552 542 + 1.057 1.326 0.956
ENSG00000188343 E026 5.5117627 0.0065940264 0.14994630 0.26160622 8 93705951 93706064 114 + 0.704 0.911 0.815
ENSG00000188343 E027 7.2801349 0.0022569767 0.21349283 0.34264878 8 93706065 93706196 132 + 0.815 0.976 0.615
ENSG00000188343 E028 1.4308980 0.0115077311 0.35242849 0.49668971 8 93707202 93707281 80 + 0.296 0.471 1.004
ENSG00000188343 E029 44.8436201 0.0004655186 0.08074778 0.16071424 8 93708011 93708016 6 + 1.613 1.500 -0.385
ENSG00000188343 E030 2.6666401 0.0957287903 0.71609339 0.81183534 8 93709763 93709770 8 + 0.494 0.558 0.305
ENSG00000188343 E031 43.7429424 0.0006205527 0.26428241 0.40224883 8 93709771 93709774 4 + 1.597 1.526 -0.242
ENSG00000188343 E032 96.6359036 0.0003502594 0.77577230 0.85558778 8 93709775 93709875 101 + 1.920 1.909 -0.038
ENSG00000188343 E033 83.9148073 0.0021369519 0.40957801 0.55318304 8 93718675 93718788 114 + 1.847 1.887 0.135
ENSG00000188343 E034 1.7296624 0.0082646688 0.56423621 0.69155877 8 93724510 93724595 86 + 0.362 0.471 0.588
ENSG00000188343 E035 0.4386386 0.1168904317 0.57711049 0.70241212 8 93725848 93726066 219 + 0.122 0.217 0.995
ENSG00000188343 E036 99.1658933 0.0021069319 0.05549499 0.11883261 8 93726394 93726513 120 + 1.907 1.994 0.290
ENSG00000188343 E037 0.8984834 0.0703687544 0.23753493 0.37129863 8 93726514 93726704 191 + 0.296 0.000 -12.208
ENSG00000188343 E038 0.1451727 0.0431728335 1.00000000   8 93727131 93727244 114 + 0.065 0.000 -9.870
ENSG00000188343 E039 165.9315241 0.0007243096 0.03288116 0.07756683 8 93728205 93731527 3323 + 2.132 2.200 0.228