ENSG00000188342

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
MSTRG.8693.1 ENSG00000188342 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2F2 protein_coding   31.04594 16.03127 46.33992 0.6028273 2.440334 1.530778 3.378287 1.933884 4.829161 0.4637443 0.4028349 1.3158150 0.1139167 0.1189000 0.1042667 -0.01463333 0.86232043 0.04608957 FALSE TRUE
MSTRG.8693.2 ENSG00000188342 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2F2 protein_coding   31.04594 16.03127 46.33992 0.6028273 2.440334 1.530778 9.418064 4.111915 12.999043 0.9720408 1.6157672 1.6581283 0.2778083 0.2543667 0.2786333 0.02426667 0.88151572 0.04608957 FALSE TRUE
MSTRG.8693.3 ENSG00000188342 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2F2 protein_coding   31.04594 16.03127 46.33992 0.6028273 2.440334 1.530778 6.707807 7.490245 8.104068 1.7058266 0.5195502 0.1134878 0.2970458 0.4698333 0.1770333 -0.29280000 0.04608957 0.04608957 TRUE TRUE
MSTRG.8693.7 ENSG00000188342 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2F2 protein_coding   31.04594 16.03127 46.33992 0.6028273 2.440334 1.530778 10.287491 1.708697 18.982574 1.0802201 1.1176456 3.4660484 0.2667708 0.1076333 0.4095667 0.30193333 0.26020852 0.04608957 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000188342 E001 1.5426475 0.0146578782 1.220924e-01 2.229144e-01 13 45120474 45120477 4 + 0.470 0.173 -2.001
ENSG00000188342 E002 8.6767800 0.0019533925 2.091118e-01 3.374671e-01 13 45120478 45120509 32 + 1.014 0.866 -0.559
ENSG00000188342 E003 10.4890602 0.0016154315 5.997117e-02 1.265591e-01 13 45120510 45120517 8 + 1.105 0.894 -0.780
ENSG00000188342 E004 65.7298971 0.0003912595 6.616814e-02 1.369909e-01 13 45120518 45120532 15 + 1.830 1.745 -0.287
ENSG00000188342 E005 182.6242120 0.0002246956 1.359278e-01 2.423875e-01 13 45120533 45120721 189 + 2.257 2.217 -0.134
ENSG00000188342 E006 160.4628522 0.0002699741 5.350035e-02 1.153818e-01 13 45136733 45136806 74 + 2.207 2.151 -0.188
ENSG00000188342 E007 119.6621848 0.0003509489 4.553395e-03 1.469076e-02 13 45149770 45149788 19 + 2.095 1.998 -0.328
ENSG00000188342 E008 233.3933853 0.0002394898 1.453490e-02 3.944354e-02 13 45151687 45151831 145 + 2.370 2.311 -0.196
ENSG00000188342 E009 2.4658309 0.0082963559 2.904889e-01 4.313075e-01 13 45183401 45183478 78 + 0.470 0.644 0.802
ENSG00000188342 E010 0.0000000       13 45206355 45207423 1069 +      
ENSG00000188342 E011 196.2654837 0.0002515855 2.993840e-01 4.408934e-01 13 45207424 45207505 82 + 2.284 2.256 -0.090
ENSG00000188342 E012 0.0000000       13 45219353 45219619 267 +      
ENSG00000188342 E013 0.2987644 0.0278262301 5.298360e-01   13 45220866 45220909 44 + 0.157 0.000 -8.845
ENSG00000188342 E014 201.0031388 0.0020928475 9.303814e-01 9.602042e-01 13 45252871 45252970 100 + 2.286 2.281 -0.018
ENSG00000188342 E015 253.1967443 0.0003021125 9.348619e-01 9.630026e-01 13 45267233 45267376 144 + 2.385 2.384 -0.005
ENSG00000188342 E016 278.4209574 0.0001756619 8.631494e-01 9.157510e-01 13 45283442 45283643 202 + 2.428 2.425 -0.009
ENSG00000188342 E017 110.0052689 0.0002878519 6.101046e-01 7.294663e-01 13 45283644 45283657 14 + 2.019 2.038 0.063
ENSG00000188342 E018 285.5089962 0.0002172338 7.297164e-15 2.455463e-13 13 45283658 45284047 390 + 2.375 2.537 0.542
ENSG00000188342 E019 37.7413440 0.0081601849 5.952524e-02 1.258089e-01 13 45284048 45284171 124 + 1.518 1.651 0.455
ENSG00000188342 E020 17.5832759 0.0010519690 6.014672e-02 1.268535e-01 13 45284172 45284893 722 + 1.186 1.342 0.549
ENSG00000188342 E021 0.5117906 0.1837015589 8.901718e-01 9.338352e-01 13 45285801 45285823 23 + 0.156 0.174 0.188
ENSG00000188342 E022 0.8073328 0.0153127045 6.683751e-01 7.754050e-01 13 45285824 45285962 139 + 0.218 0.296 0.583