ENSG00000188313

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000342435 ENSG00000188313 HEK293_OSMI2_2hA HEK293_TMG_2hB PLSCR1 protein_coding protein_coding 12.8883 8.747299 17.32865 1.073822 1.14549 0.9854336 1.2860729 2.53555036 1.5173033 0.36022916 0.3562714 -0.736991 0.11473333 0.289266667 0.09033333 -0.198933333 0.0008676701 0.0008676701 FALSE TRUE
ENST00000448787 ENSG00000188313 HEK293_OSMI2_2hA HEK293_TMG_2hB PLSCR1 protein_coding protein_coding 12.8883 8.747299 17.32865 1.073822 1.14549 0.9854336 2.1156324 1.03791385 3.6674191 0.53419605 0.9275163 1.811174 0.16111250 0.113666667 0.20750000 0.093833333 0.6709807651 0.0008676701 FALSE TRUE
ENST00000462666 ENSG00000188313 HEK293_OSMI2_2hA HEK293_TMG_2hB PLSCR1 protein_coding protein_coding 12.8883 8.747299 17.32865 1.073822 1.14549 0.9854336 0.3364151 0.02700944 1.2235117 0.02700944 0.7241084 5.058734 0.02159583 0.002466667 0.07426667 0.071800000 0.4375882714 0.0008676701 FALSE FALSE
ENST00000469266 ENSG00000188313 HEK293_OSMI2_2hA HEK293_TMG_2hB PLSCR1 protein_coding retained_intron 12.8883 8.747299 17.32865 1.073822 1.14549 0.9854336 0.7346646 0.66548141 0.5627963 0.09352297 0.0645343 -0.237894 0.06654583 0.080233333 0.03226667 -0.047966667 0.0538305196 0.0008676701 FALSE TRUE
ENST00000487389 ENSG00000188313 HEK293_OSMI2_2hA HEK293_TMG_2hB PLSCR1 protein_coding protein_coding 12.8883 8.747299 17.32865 1.073822 1.14549 0.9854336 6.6008311 4.01506286 8.1102179 0.54762666 0.8873470 1.012507 0.50130000 0.460666667 0.46543333 0.004766667 0.9790341549 0.0008676701 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000188313 E001 0.2966881 0.0267763441 3.071997e-01   3 146515180 146515180 1 - 0.194 0.000 -12.297
ENSG00000188313 E002 27.2069368 0.0168415268 5.586358e-07 4.897357e-06 3 146515181 146515801 621 - 1.179 1.636 1.585
ENSG00000188313 E003 11.0057638 0.0029796215 1.030839e-06 8.526803e-06 3 146515802 146515816 15 - 0.784 1.287 1.854
ENSG00000188313 E004 36.2659001 0.0066083728 3.464270e-03 1.162305e-02 3 146515817 146515951 135 - 1.478 1.673 0.665
ENSG00000188313 E005 33.4728917 0.0006859677 6.032100e-01 7.240515e-01 3 146515952 146515954 3 - 1.535 1.564 0.098
ENSG00000188313 E006 80.6840614 0.0021283240 5.055821e-01 6.413459e-01 3 146515955 146516058 104 - 1.908 1.936 0.096
ENSG00000188313 E007 59.4654639 0.0004978027 8.821258e-01 9.285156e-01 3 146516059 146516069 11 - 1.794 1.785 -0.029
ENSG00000188313 E008 64.2455820 0.0035640107 6.694060e-01 7.762228e-01 3 146516070 146516087 18 - 1.811 1.836 0.085
ENSG00000188313 E009 63.0967212 0.0006629103 3.249363e-01 4.683583e-01 3 146516088 146516101 14 - 1.796 1.838 0.141
ENSG00000188313 E010 4.9001681 0.0115399902 1.791105e-02 4.694448e-02 3 146516440 146516696 257 - 0.906 0.559 -1.427
ENSG00000188313 E011 1.0340911 0.0121805033 1.089235e-01 2.039437e-01 3 146516903 146517005 103 - 0.430 0.138 -2.174
ENSG00000188313 E012 57.1558481 0.0009142339 3.000134e-01 4.416314e-01 3 146517006 146517011 6 - 1.750 1.798 0.160
ENSG00000188313 E013 64.9515181 0.0004119169 1.665866e-01 2.837567e-01 3 146517012 146517022 11 - 1.800 1.857 0.192
ENSG00000188313 E014 100.6188193 0.0004918589 9.893025e-01 9.973187e-01 3 146517023 146517088 66 - 2.015 2.011 -0.012
ENSG00000188313 E015 100.5256661 0.0037230122 8.955340e-01 9.372547e-01 3 146517089 146517148 60 - 2.015 2.000 -0.048
ENSG00000188313 E016 65.4098352 0.0105736202 5.899094e-01 7.129034e-01 3 146517149 146517157 9 - 1.810 1.833 0.080
ENSG00000188313 E017 62.1882390 0.0056580966 2.636491e-01 4.015655e-01 3 146517158 146517167 10 - 1.774 1.828 0.183
ENSG00000188313 E018 0.7029582 0.0160959522 1.942605e-01 3.190912e-01 3 146517168 146517394 227 - 0.108 0.328 1.998
ENSG00000188313 E019 0.4502799 0.0374841885 1.493064e-01 2.607188e-01 3 146520166 146520180 15 - 0.266 0.000 -12.882
ENSG00000188313 E020 146.7597308 0.0009203579 4.491800e-01 5.903813e-01 3 146521544 146521701 158 - 2.164 2.181 0.058
ENSG00000188313 E021 52.6051969 0.0005261263 4.524660e-01 5.933173e-01 3 146521702 146521705 4 - 1.753 1.713 -0.134
ENSG00000188313 E022 0.7511326 0.4609614606 9.639255e-01 9.812406e-01 3 146521706 146521716 11 - 0.268 0.236 -0.243
ENSG00000188313 E023 2.1988807 0.2214984071 6.443763e-01 7.566986e-01 3 146521717 146521832 116 - 0.475 0.550 0.360
ENSG00000188313 E024 115.3474930 0.0002528700 5.199234e-02 1.127124e-01 3 146521833 146521981 149 - 2.100 2.035 -0.220
ENSG00000188313 E025 66.3885622 0.0003700393 5.435519e-02 1.168689e-01 3 146521982 146522053 72 - 1.873 1.788 -0.286
ENSG00000188313 E026 0.7279398 0.2282209806 8.780376e-02 1.717961e-01 3 146525529 146525604 76 - 0.381 0.000 -13.612
ENSG00000188313 E027 45.1947914 0.0019497272 6.986024e-03 2.118791e-02 3 146525605 146525647 43 - 1.737 1.585 -0.517
ENSG00000188313 E028 12.1133994 0.0081309963 8.968753e-03 2.620132e-02 3 146527943 146528613 671 - 0.976 1.234 0.932
ENSG00000188313 E029 94.3487783 0.0037755972 2.233146e-01 3.543448e-01 3 146528614 146528831 218 - 2.011 1.948 -0.210
ENSG00000188313 E030 80.4616721 0.0035560343 9.392700e-02 1.812700e-01 3 146533470 146533550 81 - 1.955 1.866 -0.298
ENSG00000188313 E031 37.7663786 0.0148248151 5.178894e-01 6.522143e-01 3 146536540 146536565 26 - 1.622 1.553 -0.234
ENSG00000188313 E032 0.1472490 0.0473801042 6.653488e-01   3 146536566 146536819 254 - 0.108 0.000 -11.296
ENSG00000188313 E033 1.1950578 0.2746169093 2.982461e-02 7.161832e-02 3 146537996 146538044 49 - 0.514 0.000 -14.302
ENSG00000188313 E034 0.0000000       3 146540853 146541133 281 -      
ENSG00000188313 E035 0.1451727 0.0433431433 6.665768e-01   3 146541134 146541180 47 - 0.108 0.000 -11.296
ENSG00000188313 E036 84.8400687 0.0214927229 1.413792e-01 2.499311e-01 3 146544467 146544856 390 - 1.996 1.853 -0.478