ENSG00000188312

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000375587 ENSG00000188312 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPP protein_coding protein_coding 8.696802 5.910482 11.84501 0.2994666 0.5726843 1.001711 1.887226 1.831794 1.895505 0.04484172 0.08796094 0.04906137 0.2811958 0.3114333 0.1615 -0.1499333 0.0006579391 0.0006579391 FALSE TRUE
ENST00000618653 ENSG00000188312 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPP protein_coding protein_coding 8.696802 5.910482 11.84501 0.2994666 0.5726843 1.001711 5.672419 3.526977 8.268290 0.36107140 0.63896332 1.22681621 0.5847208 0.5935000 0.6960 0.1025000 0.1644303625 0.0006579391 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000188312 E001 8.9359610 0.0309124800 4.215296e-01 5.646714e-01 9 92325930 92325951 22 + 1.050 0.944 -0.394
ENSG00000188312 E002 8.0975088 0.0033951306 1.146917e-01 2.123846e-01 9 92325952 92325952 1 + 1.039 0.865 -0.653
ENSG00000188312 E003 21.0267324 0.0172514346 1.438106e-01 2.531909e-01 9 92325953 92325998 46 + 1.405 1.267 -0.483
ENSG00000188312 E004 37.0770092 0.0089124362 1.021980e-01 1.938591e-01 9 92325999 92326105 107 + 1.631 1.515 -0.395
ENSG00000188312 E005 74.0237425 0.0015074933 7.770765e-03 2.320390e-02 9 92332170 92332351 182 + 1.923 1.814 -0.368
ENSG00000188312 E006 65.2145066 0.0003912369 8.429916e-03 2.486218e-02 9 92337541 92337629 89 + 1.870 1.763 -0.359
ENSG00000188312 E007 63.7997126 0.0004177497 1.837986e-02 4.796627e-02 9 92345699 92345787 89 + 1.856 1.760 -0.323
ENSG00000188312 E008 63.1798021 0.0003714644 4.433143e-01 5.848792e-01 9 92379763 92379859 97 + 1.822 1.795 -0.090
ENSG00000188312 E009 0.2955422 0.0290080566 8.546315e-01   9 92379860 92379865 6 + 0.109 0.137 0.387
ENSG00000188312 E010 0.0000000       9 92600257 92600508 252 +      
ENSG00000188312 E011 2.1328095 0.0504339194 1.341497e-01 2.399209e-01 9 92610544 92611313 770 + 0.330 0.603 1.403
ENSG00000188312 E012 59.1016542 0.0005028181 8.123023e-01 8.809622e-01 9 92611314 92611393 80 + 1.773 1.790 0.058
ENSG00000188312 E013 62.2129880 0.0004321593 4.778391e-01 6.163333e-01 9 92612523 92612614 92 + 1.815 1.790 -0.082
ENSG00000188312 E014 283.1538234 0.0003537678 8.234120e-04 3.343183e-03 9 92613019 92617081 4063 + 2.481 2.423 -0.191
ENSG00000188312 E015 52.3898650 0.0101795057 7.094383e-01 8.068204e-01 9 92617082 92618314 1233 + 1.713 1.741 0.097
ENSG00000188312 E016 13.5246209 0.0013833354 3.494558e-01 4.936681e-01 9 92618315 92618432 118 + 1.121 1.211 0.320
ENSG00000188312 E017 94.4840356 0.0004207479 2.191452e-10 3.643068e-09 9 92618433 92619858 1426 + 1.856 2.088 0.778
ENSG00000188312 E018 70.2212794 0.0065538422 6.575814e-14 1.917452e-12 9 92619859 92620602 744 + 1.595 2.025 1.452
ENSG00000188312 E019 0.8147328 0.1617133639 5.150386e-01 6.497583e-01 9 92621539 92621645 107 + 0.196 0.325 0.964
ENSG00000188312 E020 1.7650733 0.0770009379 2.521434e-01 3.884716e-01 9 92631586 92632023 438 + 0.330 0.555 1.185
ENSG00000188312 E021 3.8008594 0.0042257538 4.186406e-01 5.618741e-01 9 92632565 92632873 309 + 0.616 0.738 0.515
ENSG00000188312 E022 0.1515154 0.0436546587 6.197572e-01   9 92634656 92634842 187 + 0.109 0.000 -8.041