ENSG00000188283

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000586068 ENSG00000188283 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF383 protein_coding retained_intron 1.165455 0.5713532 1.558041 0.1251729 0.06736513 1.431477 0.1669439 0.007182115 0.4384664 0.007182115 0.006718456 4.7060202 0.12976667 0.01193333 0.28233333 0.27040000 3.062416e-04 2.15889e-09 FALSE TRUE
ENST00000586658 ENSG00000188283 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF383 protein_coding retained_intron 1.165455 0.5713532 1.558041 0.1251729 0.06736513 1.431477 0.1286643 0.255002377 0.0000000 0.084251764 0.000000000 -4.7279334 0.14485833 0.42460000 0.00000000 -0.42460000 2.158890e-09 2.15889e-09   FALSE
ENST00000589413 ENSG00000188283 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF383 protein_coding protein_coding 1.165455 0.5713532 1.558041 0.1251729 0.06736513 1.431477 0.1954927 0.142922256 0.1092443 0.079018937 0.077365944 -0.3588784 0.20079583 0.30360000 0.06726667 -0.23633333 5.431473e-01 2.15889e-09 FALSE TRUE
ENST00000684119 ENSG00000188283 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF383 protein_coding protein_coding 1.165455 0.5713532 1.558041 0.1251729 0.06736513 1.431477 0.1997007 0.099224243 0.1240713 0.099224243 0.124071337 0.2957077 0.14316667 0.12863333 0.08576667 -0.04286667 8.812400e-01 2.15889e-09 FALSE TRUE
MSTRG.17060.3 ENSG00000188283 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF383 protein_coding   1.165455 0.5713532 1.558041 0.1251729 0.06736513 1.431477 0.2388663 0.000000000 0.3392784 0.000000000 0.085952752 5.1263057 0.17430833 0.00000000 0.22293333 0.22293333 4.959432e-03 2.15889e-09 FALSE TRUE
MSTRG.17060.6 ENSG00000188283 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF383 protein_coding   1.165455 0.5713532 1.558041 0.1251729 0.06736513 1.431477 0.1053011 0.021738247 0.4910431 0.021738247 0.250361704 3.9806403 0.08787917 0.06376667 0.30623333 0.24246667 5.691996e-01 2.15889e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000188283 E001 1.7703363 0.0190200832 0.363946003 0.50835714 19 37217926 37218182 257 + 0.422 0.233 -1.210
ENSG00000188283 E002 0.7384352 0.0179479271 0.376337194 0.52067065 19 37218183 37218189 7 + 0.242 0.000 -12.767
ENSG00000188283 E003 1.7766790 0.0189989473 0.363936888 0.50834815 19 37218190 37218213 24 + 0.422 0.233 -1.210
ENSG00000188283 E004 1.7766790 0.0189989473 0.363936888 0.50834815 19 37218214 37218217 4 + 0.422 0.233 -1.210
ENSG00000188283 E005 5.9065736 0.0258762403 0.238110871 0.37194549 19 37218218 37218274 57 + 0.794 0.585 -0.877
ENSG00000188283 E006 0.2214452 0.0384386116 0.084587367   19 37218280 37218329 50 + 0.000 0.233 12.721
ENSG00000188283 E007 1.4339178 0.4132307479 0.175687395 0.29557838 19 37219276 37219490 215 + 0.242 0.582 1.918
ENSG00000188283 E008 1.5864774 0.1888445967 0.054434466 0.11701536 19 37219599 37219687 89 + 0.242 0.654 2.231
ENSG00000188283 E009 3.4667249 0.0134664517 0.111941935 0.20841094 19 37219688 37219749 62 + 0.510 0.776 1.151
ENSG00000188283 E010 8.2768657 0.0021440232 0.869216155 0.91995882 19 37224818 37224939 122 + 0.879 0.908 0.113
ENSG00000188283 E011 0.1482932 0.0409017697 0.085697526   19 37224940 37225212 273 + 0.000 0.233 12.705
ENSG00000188283 E012 0.0000000       19 37226464 37226676 213 +      
ENSG00000188283 E013 0.2965864 0.0650923983 0.016873761   19 37227550 37227743 194 + 0.000 0.382 13.538
ENSG00000188283 E014 7.8757659 0.0023914265 0.443995419 0.58557804 19 37230409 37230411 3 + 0.879 0.776 -0.401
ENSG00000188283 E015 13.0010299 0.0050008988 0.137708935 0.24489158 19 37230412 37230462 51 + 1.086 0.909 -0.654
ENSG00000188283 E016 15.7004830 0.0013592467 0.007270629 0.02192821 19 37235549 37235675 127 + 1.181 0.869 -1.149
ENSG00000188283 E017 1.9389173 0.0441472077 0.323588621 0.46689104 19 37235676 37235758 83 + 0.446 0.233 -1.340
ENSG00000188283 E018 2.8120298 0.0093646594 0.108511679 0.20335957 19 37235759 37235978 220 + 0.566 0.233 -1.920
ENSG00000188283 E019 13.8644662 0.0020880089 0.150979812 0.26298890 19 37235979 37236074 96 + 1.107 0.945 -0.592
ENSG00000188283 E020 124.9308375 0.0004495376 0.004605033 0.01483412 19 37242469 37248740 6272 + 1.990 2.067 0.257