ENSG00000188177

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000343936 ENSG00000188177 HEK293_OSMI2_2hA HEK293_TMG_2hB ZC3H6 protein_coding protein_coding 1.104938 0.4425496 1.59035 0.03569722 0.08644276 1.822239 0.30812003 0.24411295 0.24670168 0.01668638 0.13747817 0.01462281 0.34606667 0.55926667 0.14713333 -0.41213333 0.1147837202 6.94716e-05 FALSE TRUE
ENST00000409871 ENSG00000188177 HEK293_OSMI2_2hA HEK293_TMG_2hB ZC3H6 protein_coding protein_coding 1.104938 0.4425496 1.59035 0.03569722 0.08644276 1.822239 0.07834209 0.00000000 0.12623011 0.00000000 0.12623011 3.76797368 0.09215833 0.00000000 0.08906667 0.08906667 1.0000000000 6.94716e-05 FALSE TRUE
ENST00000476511 ENSG00000188177 HEK293_OSMI2_2hA HEK293_TMG_2hB ZC3H6 protein_coding retained_intron 1.104938 0.4425496 1.59035 0.03569722 0.08644276 1.822239 0.24250800 0.18011062 0.42388986 0.02382488 0.14033509 1.19048971 0.25194583 0.40476667 0.25980000 -0.14496667 0.5632645096 6.94716e-05 FALSE TRUE
ENST00000502881 ENSG00000188177 HEK293_OSMI2_2hA HEK293_TMG_2hB ZC3H6 protein_coding processed_transcript 1.104938 0.4425496 1.59035 0.03569722 0.08644276 1.822239 0.04813709 0.01832607 0.08411944 0.01832607 0.02735377 1.73236219 0.05027083 0.03593333 0.05410000 0.01816667 0.9793253356 6.94716e-05   FALSE
MSTRG.19047.1 ENSG00000188177 HEK293_OSMI2_2hA HEK293_TMG_2hB ZC3H6 protein_coding   1.104938 0.4425496 1.59035 0.03569722 0.08644276 1.822239 0.42783086 0.00000000 0.70940846 0.00000000 0.11639658 6.16873922 0.25955833 0.00000000 0.44990000 0.44990000 0.0000694716 6.94716e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000188177 E001 0.8136755 0.0146481101 5.809989e-01 7.056261e-01 2 112275597 112275600 4 + 0.211 0.305 0.701
ENSG00000188177 E002 3.5752365 0.0049408549 2.110263e-01 3.397435e-01 2 112275601 112275637 37 + 0.569 0.746 0.756
ENSG00000188177 E003 9.0743082 0.0024386480 6.728272e-03 2.051682e-02 2 112275638 112276026 389 + 0.860 1.137 1.024
ENSG00000188177 E004 1.5260995 0.0922733591 9.186469e-01 9.526137e-01 2 112299849 112299855 7 + 0.391 0.400 0.047
ENSG00000188177 E005 4.3876575 0.0072101368 3.497206e-01 4.939169e-01 2 112299856 112300029 174 + 0.763 0.607 -0.654
ENSG00000188177 E006 4.5965190 0.0069609676 1.402234e-01 2.483267e-01 2 112303229 112303351 123 + 0.793 0.549 -1.035
ENSG00000188177 E007 12.3239176 0.0016952543 3.334379e-03 1.124680e-02 2 112309885 112310161 277 + 1.187 0.851 -1.238
ENSG00000188177 E008 9.4505889 0.0019784580 2.023060e-01 3.291051e-01 2 112311804 112311937 134 + 1.042 0.881 -0.599
ENSG00000188177 E009 2.1400972 0.0070653868 1.382840e-02 3.783685e-02 2 112311938 112312192 255 + 0.310 0.704 1.963
ENSG00000188177 E010 5.5005430 0.0041257846 2.175200e-03 7.765373e-03 2 112316470 112316586 117 + 0.908 0.402 -2.217
ENSG00000188177 E011 5.6437411 0.0482835334 2.020592e-04 9.727217e-04 2 112317221 112317332 112 + 0.940 0.179 -3.922
ENSG00000188177 E012 0.4482035 0.0286721386 3.484726e-01 4.927073e-01 2 112317333 112317334 2 + 0.211 0.000 -10.476
ENSG00000188177 E013 1.3255824 0.3202487760 9.637406e-02 1.849244e-01 2 112321756 112321757 2 + 0.458 0.000 -11.331
ENSG00000188177 E014 3.2851117 0.0053200425 3.910603e-03 1.289290e-02 2 112321758 112321865 108 + 0.731 0.178 -3.106
ENSG00000188177 E015 6.0778197 0.0042610308 3.990260e-01 5.427769e-01 2 112322649 112322902 254 + 0.873 0.746 -0.500
ENSG00000188177 E016 9.8516568 0.0020900481 9.393057e-05 4.934109e-04 2 112324152 112324663 512 + 1.130 0.607 -2.037
ENSG00000188177 E017 5.2029245 0.0413927146 2.285268e-03 8.106019e-03 2 112324964 112325197 234 + 0.896 0.304 -2.761
ENSG00000188177 E018 21.3305305 0.0228804094 3.992636e-01 5.429957e-01 2 112331005 112332141 1137 + 1.352 1.252 -0.350
ENSG00000188177 E019 6.4602925 0.0029921119 1.909736e-01 3.149731e-01 2 112332142 112332282 141 + 0.896 0.705 -0.758
ENSG00000188177 E020 12.7639659 0.0615181509 2.831272e-01 4.232131e-01 2 112332283 112333976 1694 + 1.059 1.192 0.479
ENSG00000188177 E021 54.9871911 0.0007022604 1.506774e-14 4.840660e-13 2 112333977 112340063 6087 + 1.604 1.896 0.988