ENSG00000188070

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000433688 ENSG00000188070 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFTA protein_coding protein_coding 13.89848 17.58807 14.14391 0.5207711 0.5204071 -0.3142174 11.800462 16.8216081 10.281044 0.36860698 0.2601242 -0.7097837 0.8418792 0.95690000 0.7298333 -0.2270667 2.422757e-08 1.678101e-10 FALSE TRUE
MSTRG.5642.2 ENSG00000188070 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFTA protein_coding   13.89848 17.58807 14.14391 0.5207711 0.5204071 -0.3142174 1.688081 0.6163104 3.612959 0.09992167 0.6709316 2.5322187 0.1312958 0.03476667 0.2527000 0.2179333 1.678101e-10 1.678101e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000188070 E001 787.89029 0.013038524 7.862898e-07 6.680131e-06 11 63759892 63760734 843 - 2.697 2.970 0.907
ENSG00000188070 E002 1390.26600 0.001901147 5.946076e-02 1.257091e-01 11 63760735 63763302 2568 - 3.111 3.142 0.105
ENSG00000188070 E003 45.37657 0.094283778 3.139352e-03 1.067527e-02 11 63763303 63763413 111 - 1.842 1.472 -1.259
ENSG00000188070 E004 117.40348 0.028646852 1.771308e-03 6.508195e-03 11 63763414 63763869 456 - 2.173 1.970 -0.680
ENSG00000188070 E005 12.73508 0.002249371 2.642388e-02 6.479323e-02 11 63764038 63764181 144 - 1.216 1.057 -0.568
ENSG00000188070 E006 41.36261 0.006254449 6.496784e-02 1.349809e-01 11 63764182 63764598 417 - 1.650 1.581 -0.235
ENSG00000188070 E007 28.12413 0.005220817 4.217980e-01 5.649309e-01 11 63764868 63764919 52 - 1.455 1.448 -0.024
ENSG00000188070 E008 38.15667 0.014601468 6.431146e-01 7.557275e-01 11 63764920 63765042 123 - 1.571 1.583 0.043
ENSG00000188070 E009 31.05539 0.012224504 4.141233e-01 5.575255e-01 11 63765043 63765254 212 - 1.499 1.484 -0.052
ENSG00000188070 E010 174.47631 0.013219340 3.445624e-05 2.018127e-04 11 63765807 63766304 498 - 2.338 2.148 -0.635
ENSG00000188070 E011 4.23323 0.056712924 9.967667e-02 1.899972e-01 11 63767323 63767554 232 - 0.822 0.588 -0.975
ENSG00000188070 E012 30.76829 0.014273463 4.165192e-05 2.390582e-04 11 63768484 63768775 292 - 1.643 1.353 -0.996