ENSG00000187994

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000591812 ENSG00000187994 HEK293_OSMI2_2hA HEK293_TMG_2hB RINL protein_coding protein_coding 0.2712059 0.3951586 0.2971387 0.03268534 0.01836684 -0.3995963 0.117835275 0.12003876 0.119797165 0.06163791 0.060047811 -0.002682834 0.48810833 0.3285333 0.42666667 0.09813333 0.8999251076 0.0003172148 FALSE TRUE
ENST00000593424 ENSG00000187994 HEK293_OSMI2_2hA HEK293_TMG_2hB RINL protein_coding protein_coding 0.2712059 0.3951586 0.2971387 0.03268534 0.01836684 -0.3995963 0.057074923 0.22434495 0.008580037 0.04948729 0.008580037 -3.656808409 0.22366667 0.5534333 0.02603333 -0.52740000 0.0003172148 0.0003172148 FALSE FALSE
ENST00000596919 ENSG00000187994 HEK293_OSMI2_2hA HEK293_TMG_2hB RINL protein_coding retained_intron 0.2712059 0.3951586 0.2971387 0.03268534 0.01836684 -0.3995963 0.008475802 0.00000000 0.036328605 0.00000000 0.036328605 2.211903257 0.03050417 0.0000000 0.12273333 0.12273333 0.7492405507 0.0003172148   FALSE
ENST00000598048 ENSG00000187994 HEK293_OSMI2_2hA HEK293_TMG_2hB RINL protein_coding retained_intron 0.2712059 0.3951586 0.2971387 0.03268534 0.01836684 -0.3995963 0.026794524 0.00000000 0.062491127 0.00000000 0.031245774 2.857804420 0.11107917 0.0000000 0.21230000 0.21230000 0.1616201422 0.0003172148   FALSE
ENST00000598904 ENSG00000187994 HEK293_OSMI2_2hA HEK293_TMG_2hB RINL protein_coding protein_coding 0.2712059 0.3951586 0.2971387 0.03268534 0.01836684 -0.3995963 0.016049388 0.05077485 0.069941764 0.05077485 0.069941764 0.395475086 0.08295417 0.1180333 0.21226667 0.09423333 1.0000000000 0.0003172148 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000187994 E001 0.0000000       19 38867830 38867833 4 -      
ENSG00000187994 E002 6.2518056 0.003719794 0.001473181 0.005549719 19 38867834 38868981 1148 - 0.530 0.940 1.689
ENSG00000187994 E003 2.2216682 0.007243862 0.864458477 0.916626452 19 38868982 38869166 185 - 0.476 0.495 0.093
ENSG00000187994 E004 1.0726966 0.012959846 0.204245738 0.331477862 19 38869167 38869230 64 - 0.146 0.367 1.737
ENSG00000187994 E005 0.8846626 0.014989589 0.326018762 0.469461368 19 38869231 38869246 16 - 0.146 0.315 1.415
ENSG00000187994 E006 2.2884034 0.008206691 0.699362778 0.799143728 19 38869247 38869283 37 - 0.476 0.530 0.261
ENSG00000187994 E007 2.1368880 0.007952465 0.454241137 0.594903808 19 38869284 38869410 127 - 0.414 0.530 0.583
ENSG00000187994 E008 1.2209923 0.011448002 0.212791796 0.341830610 19 38869573 38869704 132 - 0.476 0.254 -1.324
ENSG00000187994 E009 0.0000000       19 38869705 38869834 130 -      
ENSG00000187994 E010 0.0000000       19 38869835 38869921 87 -      
ENSG00000187994 E011 0.0000000       19 38869922 38869925 4 -      
ENSG00000187994 E012 0.7415557 0.020357199 0.074793420 0.151194983 19 38869943 38870043 101 - 0.414 0.102 -2.587
ENSG00000187994 E013 1.3963394 0.013489475 0.849160370 0.906381226 19 38870044 38870260 217 - 0.342 0.367 0.154
ENSG00000187994 E014 1.1812238 0.221740528 0.999768318 1.000000000 19 38870570 38870651 82 - 0.341 0.316 -0.162
ENSG00000187994 E015 1.3608519 0.011338768 0.853332452 0.909215666 19 38870652 38870747 96 - 0.342 0.367 0.152
ENSG00000187994 E016 1.5833413 0.009900106 0.238815806 0.372758207 19 38870748 38870851 104 - 0.255 0.456 1.223
ENSG00000187994 E017 2.2121033 0.007334412 0.452761601 0.593577528 19 38870852 38870992 141 - 0.414 0.530 0.585
ENSG00000187994 E018 2.7700051 0.006767026 0.584604095 0.708483079 19 38871078 38871227 150 - 0.622 0.530 -0.416
ENSG00000187994 E019 0.0000000       19 38871228 38871465 238 -      
ENSG00000187994 E020 0.0000000       19 38871466 38871646 181 -      
ENSG00000187994 E021 2.5465576 0.059313367 0.349494838 0.493697421 19 38871647 38871711 65 - 0.622 0.459 -0.764
ENSG00000187994 E022 0.0000000       19 38871712 38871797 86 -      
ENSG00000187994 E023 2.2541385 0.008161227 0.018039548 0.047217914 19 38871798 38871870 73 - 0.698 0.315 -1.906
ENSG00000187994 E024 0.0000000       19 38873751 38873885 135 -      
ENSG00000187994 E025 2.0273933 0.009024928 0.213898412 0.343128447 19 38873886 38873988 103 - 0.579 0.367 -1.068
ENSG00000187994 E026 1.5468358 0.012784381 0.646884806 0.758675593 19 38876331 38876474 144 - 0.342 0.414 0.416
ENSG00000187994 E027 0.8438776 0.250691169 0.958547776 0.978026005 19 38876475 38876490 16 - 0.255 0.256 0.008
ENSG00000187994 E028 0.2966881 0.030024688 0.114439475   19 38876491 38876692 202 - 0.255 0.000 -10.579
ENSG00000187994 E029 1.2845925 0.013077157 0.593978245 0.716269663 19 38876693 38876781 89 - 0.414 0.314 -0.586
ENSG00000187994 E030 0.8189741 0.016696360 0.073859771 0.149681350 19 38878232 38878257 26 - 0.414 0.102 -2.584
ENSG00000187994 E031 0.0000000       19 38878258 38878264 7 -      
ENSG00000187994 E032 0.0000000       19 38878265 38878266 2 -      
ENSG00000187994 E033 0.0000000       19 38878267 38878273 7 -      
ENSG00000187994 E034 0.0000000       19 38878274 38878275 2 -