ENSG00000187953

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000348899 ENSG00000187953 HEK293_OSMI2_2hA HEK293_TMG_2hB PMS2CL transcribed_unprocessed_pseudogene processed_transcript 5.312748 3.094764 8.010124 0.2563087 0.2954934 1.369141 2.2571618 1.116092 3.6527882 0.08830565 0.2627798 1.7016182 0.4191250 0.3612333 0.45493333 0.09370000 2.087548e-01 2.551406e-07   FALSE
ENST00000486256 ENSG00000187953 HEK293_OSMI2_2hA HEK293_TMG_2hB PMS2CL transcribed_unprocessed_pseudogene processed_transcript 5.312748 3.094764 8.010124 0.2563087 0.2954934 1.369141 1.4971087 1.523477 1.7264076 0.19066924 0.1688693 0.1792995 0.3149208 0.4889000 0.21473333 -0.27416667 2.551406e-07 2.551406e-07 TRUE TRUE
MSTRG.29482.2 ENSG00000187953 HEK293_OSMI2_2hA HEK293_TMG_2hB PMS2CL transcribed_unprocessed_pseudogene   5.312748 3.094764 8.010124 0.2563087 0.2954934 1.369141 0.4157598 0.000000 1.0932044 0.00000000 0.3602295 6.7855563 0.0620750 0.0000000 0.13513333 0.13513333 3.447507e-05 2.551406e-07 TRUE TRUE
MSTRG.29482.3 ENSG00000187953 HEK293_OSMI2_2hA HEK293_TMG_2hB PMS2CL transcribed_unprocessed_pseudogene   5.312748 3.094764 8.010124 0.2563087 0.2954934 1.369141 0.5892220 0.000000 0.7344866 0.00000000 0.3728396 6.2181740 0.0932125 0.0000000 0.09496667 0.09496667 3.249959e-01 2.551406e-07 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000187953 E001 0.1451727 0.0428666624 1.000000e+00   7 6710128 6710238 111 + 0.089 0.000 -9.703
ENSG00000187953 E002 0.1451727 0.0428666624 1.000000e+00   7 6710750 6710808 59 + 0.089 0.000 -9.796
ENSG00000187953 E003 0.4407149 0.0217681645 1.000000e+00 1.000000e+00 7 6711294 6711379 86 + 0.163 0.165 0.018
ENSG00000187953 E004 0.4407149 0.0217681645 1.000000e+00 1.000000e+00 7 6711380 6711417 38 + 0.163 0.165 0.018
ENSG00000187953 E005 1.0653242 0.0137428478 6.317935e-01 7.467503e-01 7 6711418 6711469 52 + 0.282 0.378 0.602
ENSG00000187953 E006 0.8793520 0.2027149874 2.764608e-01 4.159301e-01 7 6729780 6729780 1 + 0.163 0.383 1.629
ENSG00000187953 E007 3.1688788 0.0404430853 7.492934e-01 8.362970e-01 7 6729781 6729802 22 + 0.623 0.578 -0.200
ENSG00000187953 E008 4.8037211 0.0151934584 8.892355e-02 1.734765e-01 7 6729803 6729803 1 + 0.827 0.578 -1.038
ENSG00000187953 E009 12.8484413 0.0014693574 4.982496e-02 1.088467e-01 7 6729804 6729930 127 + 1.188 1.011 -0.636
ENSG00000187953 E010 20.3028795 0.0009309211 6.885890e-02 1.414810e-01 7 6729931 6730117 187 + 1.361 1.236 -0.437
ENSG00000187953 E011 9.9516817 0.0019481365 1.217443e-01 2.224189e-01 7 6730118 6730133 16 + 1.078 0.925 -0.565
ENSG00000187953 E012 11.9392219 0.0017698154 1.306146e-01 2.350132e-01 7 6730134 6730181 48 + 1.147 1.011 -0.492
ENSG00000187953 E013 17.4693054 0.0083451374 5.456877e-01 6.759928e-01 7 6730182 6730301 120 + 1.274 1.234 -0.141
ENSG00000187953 E014 3.9969494 0.0114484766 5.303101e-01 6.629471e-01 7 6730634 6730727 94 + 0.646 0.751 0.436
ENSG00000187953 E015 15.5484964 0.0106968919 6.253975e-01 7.415454e-01 7 6731897 6731955 59 + 1.187 1.246 0.210
ENSG00000187953 E016 12.7614186 0.0021645705 8.816908e-02 1.723306e-01 7 6733399 6733527 129 + 1.181 1.030 -0.543
ENSG00000187953 E017 16.5966618 0.0012200678 3.275544e-01 4.710210e-01 7 6735305 6735389 85 + 1.264 1.199 -0.230
ENSG00000187953 E018 30.1665948 0.0065574865 2.481284e-01 3.837178e-01 7 6737076 6737285 210 + 1.503 1.438 -0.226
ENSG00000187953 E019 33.7714547 0.0007144416 2.906545e-01 4.314594e-01 7 6737286 6737573 288 + 1.545 1.499 -0.156
ENSG00000187953 E020 15.3361507 0.0013508828 8.175380e-01 8.846350e-01 7 6737574 6737634 61 + 1.188 1.224 0.129
ENSG00000187953 E021 30.4921445 0.0038130988 7.675186e-01 8.497300e-01 7 6737635 6737936 302 + 1.484 1.480 -0.014
ENSG00000187953 E022 0.0000000       7 6740174 6740324 151 +      
ENSG00000187953 E023 13.1249262 0.0018032407 2.252659e-01 3.567403e-01 7 6741685 6741852 168 + 1.168 1.067 -0.363
ENSG00000187953 E024 1.6146787 0.0090199621 6.901911e-01 7.919435e-01 7 6746088 6746188 101 + 0.375 0.455 0.435
ENSG00000187953 E025 0.0000000       7 6747003 6747035 33 +      
ENSG00000187953 E026 0.4720498 0.1210040231 1.000000e+00 1.000000e+00 7 6747036 6747205 170 + 0.163 0.166 0.024
ENSG00000187953 E027 0.4449813 0.0213532042 1.000000e+00 1.000000e+00 7 6751249 6751601 353 + 0.164 0.165 0.017
ENSG00000187953 E028 0.1515154 0.0441993880 1.000000e+00   7 6751602 6751641 40 + 0.089 0.000 -9.797
ENSG00000187953 E029 48.5948073 0.0072342318 4.450740e-11 8.330165e-10 7 6753022 6753862 841 + 1.497 1.894 1.347