ENSG00000187860

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000399824 ENSG00000187860 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC157 protein_coding protein_coding 7.025767 11.41057 4.514085 0.7945382 0.3378052 -1.335936 4.5916677 8.1851636 2.7610761 0.5929124 0.11004665 -1.5643264 0.62635833 0.71726667 0.61923333 -0.098033333 0.35264762 0.01586869    
ENST00000475975 ENSG00000187860 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC157 protein_coding retained_intron 7.025767 11.41057 4.514085 0.7945382 0.3378052 -1.335936 0.6077693 0.6745669 0.5782143 0.1461756 0.03927267 -0.2188495 0.09355417 0.05786667 0.12823333 0.070366667 0.01586869 0.01586869 TRUE  
MSTRG.21928.8 ENSG00000187860 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC157 protein_coding   7.025767 11.41057 4.514085 0.7945382 0.3378052 -1.335936 0.5120025 0.7574906 0.2940793 0.1042706 0.10061749 -1.3357014 0.07555000 0.06650000 0.06276667 -0.003733333 0.98907975 0.01586869 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000187860 E001 38.426360 0.0085869670 6.297595e-03 1.939444e-02 22 30356635 30357000 366 + 1.654 1.462 -0.654
ENSG00000187860 E002 19.944193 0.0515844937 5.705571e-01 6.970018e-01 22 30357001 30357006 6 + 1.303 1.224 -0.277
ENSG00000187860 E003 46.866575 0.0175032626 8.456030e-01 9.039885e-01 22 30357007 30357107 101 + 1.604 1.598 -0.020
ENSG00000187860 E004 31.418847 0.0151290236 5.374539e-01 6.690125e-01 22 30357108 30357113 6 + 1.377 1.443 0.229
ENSG00000187860 E005 37.529773 0.0089904517 2.535016e-01 3.900295e-01 22 30357114 30357132 19 + 1.424 1.524 0.341
ENSG00000187860 E006 77.212469 0.0008429363 8.310458e-02 1.644170e-01 22 30361961 30362114 154 + 1.743 1.828 0.288
ENSG00000187860 E007 1.072597 0.0486816629 3.643768e-01 5.087467e-01 22 30365944 30365989 46 + 0.420 0.249 -1.077
ENSG00000187860 E008 113.592139 0.0040127767 1.236454e-01 2.251467e-01 22 30365990 30366248 259 + 1.925 2.000 0.250
ENSG00000187860 E009 142.889900 0.0018270454 1.191764e-05 7.780822e-05 22 30366249 30367096 848 + 1.942 2.115 0.581
ENSG00000187860 E010 17.013703 0.0010988798 2.071583e-01 3.351224e-01 22 30369432 30369603 172 + 1.265 1.154 -0.393
ENSG00000187860 E011 3.312926 0.0049235241 5.982538e-01 7.198876e-01 22 30369604 30369626 23 + 0.502 0.594 0.426
ENSG00000187860 E012 16.042538 0.0076424394 1.526919e-01 2.653344e-01 22 30370326 30370434 109 + 1.265 1.128 -0.484
ENSG00000187860 E013 14.747464 0.0013185532 1.082830e-01 2.030013e-01 22 30370435 30370508 74 + 1.238 1.090 -0.530
ENSG00000187860 E014 49.516608 0.0005491163 7.733123e-03 2.310862e-02 22 30370509 30370950 442 + 1.726 1.585 -0.480
ENSG00000187860 E015 25.254304 0.0015317816 5.590770e-06 3.935914e-05 22 30370951 30371649 699 + 1.560 1.236 -1.126
ENSG00000187860 E016 20.937467 0.0010234282 3.216681e-01 4.649246e-01 22 30371650 30371727 78 + 1.325 1.245 -0.280
ENSG00000187860 E017 23.830679 0.0008717042 8.028036e-01 8.744149e-01 22 30372075 30372286 212 + 1.302 1.324 0.077
ENSG00000187860 E018 22.611685 0.0010611123 9.526952e-02 1.832818e-01 22 30373597 30373691 95 + 1.397 1.268 -0.449
ENSG00000187860 E019 20.322071 0.0345441330 9.959404e-01 1.000000e+00 22 30373692 30373764 73 + 1.265 1.254 -0.038
ENSG00000187860 E020 3.473980 0.0068717162 7.138237e-01 8.101989e-01 22 30373765 30373922 158 + 0.630 0.572 -0.258
ENSG00000187860 E021 30.500655 0.0008838794 6.483134e-01 7.598471e-01 22 30373923 30374091 169 + 1.442 1.411 -0.106
ENSG00000187860 E022 4.045015 0.0040180944 6.152597e-01 7.335652e-01 22 30375458 30375478 21 + 0.570 0.654 0.368
ENSG00000187860 E023 8.553826 0.0022146625 7.120346e-01 8.088748e-01 22 30375479 30375485 7 + 0.876 0.924 0.182
ENSG00000187860 E024 10.829329 0.0368576417 6.533935e-01 7.638784e-01 22 30375486 30375523 38 + 0.962 1.020 0.217
ENSG00000187860 E025 18.370205 0.0010674835 1.323761e-01 2.374003e-01 22 30375524 30375663 140 + 1.094 1.240 0.520
ENSG00000187860 E026 23.591097 0.0008913073 4.968582e-02 1.086004e-01 22 30376259 30376347 89 + 1.180 1.351 0.600
ENSG00000187860 E027 15.783255 0.0011587194 3.729162e-01 5.173437e-01 22 30376433 30376470 38 + 1.075 1.166 0.327
ENSG00000187860 E028 87.225485 0.0003965196 1.126672e-01 2.094422e-01 22 30376471 30378294 1824 + 1.911 1.848 -0.213
ENSG00000187860 E029 20.781900 0.0144721783 5.144194e-01 6.491345e-01 22 30378295 30378673 379 + 1.302 1.243 -0.205