ENSG00000187824

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341871 ENSG00000187824 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM220 protein_coding protein_coding 3.185132 3.740724 3.847819 0.1082741 0.8196151 0.04061658 0.2648210 0.1429162 0.5229245 0.03703599 0.03446759 1.8011904 0.09482083 0.03860000 0.1504000 0.11180000 0.02431324 0.02431324 FALSE TRUE
ENST00000455996 ENSG00000187824 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM220 protein_coding protein_coding 3.185132 3.740724 3.847819 0.1082741 0.8196151 0.04061658 0.3681707 0.4154932 0.8799185 0.21123940 0.14745189 1.0645370 0.11838750 0.11426667 0.2512667 0.13700000 0.56004959 0.02431324 FALSE TRUE
ENST00000578345 ENSG00000187824 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM220 protein_coding protein_coding 3.185132 3.740724 3.847819 0.1082741 0.8196151 0.04061658 0.1925141 0.2419850 0.0000000 0.24198499 0.00000000 -4.6552659 0.05857500 0.06116667 0.0000000 -0.06116667 0.78608748 0.02431324   TRUE
ENST00000580186 ENSG00000187824 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM220 protein_coding processed_transcript 3.185132 3.740724 3.847819 0.1082741 0.8196151 0.04061658 0.6079071 0.5595726 0.6088691 0.31018495 0.60886905 0.1197545 0.19919167 0.14563333 0.1128333 -0.03280000 0.65853079 0.02431324   FALSE
ENST00000581949 ENSG00000187824 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM220 protein_coding protein_coding 3.185132 3.740724 3.847819 0.1082741 0.8196151 0.04061658 0.0550235 0.2691872 0.0000000 0.26918719 0.00000000 -4.8031608 0.01358333 0.07460000 0.0000000 -0.07460000 0.77301395 0.02431324 FALSE FALSE
MSTRG.13663.2 ENSG00000187824 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM220 protein_coding   3.185132 3.740724 3.847819 0.1082741 0.8196151 0.04061658 1.6966953 2.1115696 1.8361073 0.07352346 0.31211343 -0.2006456 0.51544167 0.56573333 0.4854667 -0.08026667 0.38967616 0.02431324 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000187824 E001 0.0000000       17 10699015 10699267 253 -      
ENSG00000187824 E002 0.6685028 0.0168284340 0.804504599 0.875641458 17 10713226 10713267 42 - 0.200 0.236 0.300
ENSG00000187824 E003 10.7081395 0.0019175325 0.001367208 0.005199819 17 10713295 10714675 1381 - 1.211 0.875 -1.231
ENSG00000187824 E004 18.2785791 0.0527370543 0.008651125 0.025410946 17 10714676 10715421 746 - 1.418 1.094 -1.141
ENSG00000187824 E005 1.4266316 0.0122598692 0.530336971 0.662957357 17 10715422 10715425 4 - 0.441 0.319 -0.699
ENSG00000187824 E006 1.5008278 0.0126445179 0.961033182 0.979461290 17 10715426 10715429 4 - 0.392 0.388 -0.019
ENSG00000187824 E007 13.6502999 0.0013407471 0.333884037 0.477650380 17 10715430 10715588 159 - 1.134 1.199 0.231
ENSG00000187824 E008 15.6539647 0.0016794100 0.695925389 0.796379591 17 10723270 10723329 60 - 1.248 1.199 -0.176
ENSG00000187824 E009 0.1482932 0.0415661111 0.385885807   17 10724455 10724502 48 - 0.000 0.134 9.520
ENSG00000187824 E010 24.5487913 0.0017896049 0.227431260 0.359333954 17 10725011 10725134 124 - 1.373 1.432 0.204
ENSG00000187824 E011 17.5004899 0.0047839974 0.190404700 0.314264549 17 10726204 10726264 61 - 1.219 1.305 0.302
ENSG00000187824 E012 0.3332198 0.0296287803 0.851963676   17 10726265 10726365 101 - 0.112 0.134 0.300
ENSG00000187824 E013 12.2504341 0.0017030132 0.068084575 0.140189534 17 10729031 10729060 30 - 1.052 1.198 0.527
ENSG00000187824 E014 23.8022627 0.0009497495 0.123045874 0.224299260 17 10729780 10730023 244 - 1.350 1.431 0.281