ENSG00000187792

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341976 ENSG00000187792 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF70 protein_coding protein_coding 4.092365 4.605694 3.264319 0.5993334 0.1792742 -0.4953526 1.9615480 3.0036147 1.07408738 0.05669152 0.02418527 -1.4750139 0.45964583 0.67816667 0.33020000 -0.34796667 0.04134381 0.04134381 FALSE TRUE
MSTRG.21783.1 ENSG00000187792 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF70 protein_coding   4.092365 4.605694 3.264319 0.5993334 0.1792742 -0.4953526 0.3626339 0.2691785 0.58170154 0.12682476 0.29880976 1.0836819 0.09844583 0.05646667 0.16996667 0.11350000 0.33435551 0.04134381 TRUE TRUE
MSTRG.21783.3 ENSG00000187792 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF70 protein_coding   4.092365 4.605694 3.264319 0.5993334 0.1792742 -0.4953526 1.5037077 1.0343532 1.53483180 0.38231656 0.11940853 0.5648401 0.38342083 0.20933333 0.47690000 0.26756667 0.10862083 0.04134381 TRUE TRUE
MSTRG.21783.5 ENSG00000187792 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF70 protein_coding   4.092365 4.605694 3.264319 0.5993334 0.1792742 -0.4953526 0.2510735 0.2985480 0.07369871 0.20326289 0.07369871 -1.8822177 0.05459167 0.05600000 0.02296667 -0.03303333 0.70325153 0.04134381   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000187792 E001 2.071186 0.0138161460 2.200901e-01 0.3505200374 22 23731806 23731877 72 - 0.594 0.401 -0.947
ENSG00000187792 E002 75.989441 0.0110709866 8.896042e-05 0.0004701712 22 23738682 23739604 923 - 1.660 1.936 0.931
ENSG00000187792 E003 14.828033 0.0031431495 6.698520e-01 0.7765017202 22 23739605 23739708 104 - 1.194 1.174 -0.072
ENSG00000187792 E004 21.420696 0.0150965106 2.916551e-05 0.0001740422 22 23739709 23740232 524 - 0.971 1.436 1.653
ENSG00000187792 E005 304.735196 0.0048113223 8.668961e-02 0.1701045814 22 23740233 23743257 3025 - 2.410 2.481 0.235
ENSG00000187792 E006 159.717928 0.0003601034 6.531660e-02 0.1355657424 22 23743258 23744439 1182 - 2.195 2.165 -0.097
ENSG00000187792 E007 26.639069 0.0017101329 6.786368e-02 0.1398243646 22 23744440 23744475 36 - 1.475 1.368 -0.369
ENSG00000187792 E008 31.856993 0.0013444666 3.889127e-02 0.0889802790 22 23744476 23744559 84 - 1.553 1.442 -0.381
ENSG00000187792 E009 54.686668 0.0175598461 1.181252e-01 0.2172540334 22 23744560 23744948 389 - 1.772 1.684 -0.299
ENSG00000187792 E010 15.583377 0.0025027673 1.656180e-01 0.2825121894 22 23744949 23744972 24 - 1.248 1.145 -0.369
ENSG00000187792 E011 23.332963 0.0016056851 2.650475e-02 0.0649587289 22 23744973 23745087 115 - 1.443 1.302 -0.492
ENSG00000187792 E012 20.116523 0.0180425735 3.931045e-02 0.0897464030 22 23745088 23745219 132 - 1.402 1.228 -0.611
ENSG00000187792 E013 4.090083 0.0039287988 7.352421e-01 0.8260404489 22 23745380 23745491 112 - 0.638 0.704 0.278
ENSG00000187792 E014 12.158948 0.0102002046 2.256087e-03 0.0080180273 22 23750711 23750980 270 - 1.259 0.962 -1.071
ENSG00000187792 E015 2.167154 0.0082194698 2.160353e-01 0.3456284461 22 23750981 23751112 132 - 0.594 0.402 -0.943