ENSG00000187778

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000343810 ENSG00000187778 HEK293_OSMI2_2hA HEK293_TMG_2hB MCRS1 protein_coding protein_coding 145.548 248.8311 86.46973 12.80661 3.99154 -1.524791 114.256033 207.783864 61.637933 12.2735028 1.1920443 -1.753029 0.76433750 0.834400000 0.71546667 -0.11893333 1.071683e-02 3.022559e-14 FALSE TRUE
ENST00000552206 ENSG00000187778 HEK293_OSMI2_2hA HEK293_TMG_2hB MCRS1 protein_coding retained_intron 145.548 248.8311 86.46973 12.80661 3.99154 -1.524791 3.833714 2.026336 5.156891 0.4008852 0.8163738 1.343321 0.03552917 0.008033333 0.05906667 0.05103333 3.022559e-14 3.022559e-14   FALSE
ENST00000553173 ENSG00000187778 HEK293_OSMI2_2hA HEK293_TMG_2hB MCRS1 protein_coding protein_coding 145.548 248.8311 86.46973 12.80661 3.99154 -1.524791 10.037324 17.815506 6.766353 1.8540660 0.4626039 -1.395362 0.07028333 0.071233333 0.07823333 0.00700000 7.261642e-01 3.022559e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000187778 E001 2.205873 7.780692e-03 7.018787e-01 8.008481e-01 12 49556544 49556750 207 - 0.356 0.427 0.398
ENSG00000187778 E002 0.000000       12 49558295 49558298 4 -      
ENSG00000187778 E003 4.311309 4.039549e-03 1.479426e-03 5.570805e-03 12 49558299 49558300 2 - 0.000 0.700 11.806
ENSG00000187778 E004 4.311309 4.039549e-03 1.479426e-03 5.570805e-03 12 49558301 49558301 1 - 0.000 0.700 11.806
ENSG00000187778 E005 247.391866 3.906114e-03 1.255538e-02 3.486325e-02 12 49558302 49558362 61 - 2.192 2.297 0.350
ENSG00000187778 E006 671.102602 2.663190e-03 1.383659e-03 5.253107e-03 12 49558363 49558478 116 - 2.630 2.727 0.322
ENSG00000187778 E007 603.517806 2.498955e-04 2.297595e-03 8.143086e-03 12 49558479 49558503 25 - 2.618 2.674 0.185
ENSG00000187778 E008 1056.932492 1.214545e-04 6.981030e-05 3.791129e-04 12 49558504 49558572 69 - 2.862 2.916 0.178
ENSG00000187778 E009 1253.157300 2.263713e-04 3.325321e-04 1.510507e-03 12 49558573 49558642 70 - 2.941 2.989 0.158
ENSG00000187778 E010 1469.461428 1.547918e-04 8.761971e-04 3.531163e-03 12 49558643 49558729 87 - 3.018 3.056 0.127
ENSG00000187778 E011 1627.256280 1.321788e-04 6.225498e-01 7.393257e-01 12 49558843 49558970 128 - 3.093 3.094 0.003
ENSG00000187778 E012 9.289207 1.807123e-02 2.086566e-04 1.000946e-03 12 49558971 49559012 42 - 1.243 0.779 -1.716
ENSG00000187778 E013 14.884011 4.304052e-03 1.634734e-09 2.329237e-08 12 49559013 49559213 201 - 1.480 0.914 -2.020
ENSG00000187778 E014 1387.239552 3.927763e-04 1.462144e-01 2.565392e-01 12 49559214 49559301 88 - 3.010 3.028 0.060
ENSG00000187778 E015 13.728621 1.698171e-03 5.061619e-08 5.451441e-07 12 49559302 49559332 31 - 1.421 0.904 -1.854
ENSG00000187778 E016 13.156558 1.394637e-03 2.070535e-13 5.626979e-12 12 49559333 49559422 90 - 1.498 0.814 -2.466
ENSG00000187778 E017 1256.427326 1.254237e-04 9.966140e-01 1.000000e+00 12 49559453 49559535 83 - 2.986 2.981 -0.018
ENSG00000187778 E018 777.211106 1.183286e-04 7.099561e-01 8.072009e-01 12 49559729 49559737 9 - 2.773 2.774 0.002
ENSG00000187778 E019 1243.749953 9.409140e-05 9.385388e-01 9.654091e-01 12 49559738 49559821 84 - 2.982 2.976 -0.022
ENSG00000187778 E020 878.007269 1.923559e-04 9.564442e-01 9.767161e-01 12 49559939 49559967 29 - 2.828 2.824 -0.015
ENSG00000187778 E021 1121.111133 3.172785e-04 4.380507e-01 5.799259e-01 12 49560295 49560365 71 - 2.925 2.933 0.024
ENSG00000187778 E022 620.704157 1.786091e-04 6.245773e-02 1.307798e-01 12 49560366 49560370 5 - 2.650 2.680 0.100
ENSG00000187778 E023 1369.060313 7.562882e-05 9.575051e-02 1.840206e-01 12 49563001 49563139 139 - 3.005 3.021 0.051
ENSG00000187778 E024 851.166240 9.750435e-05 5.895357e-02 1.248458e-01 12 49563438 49563486 49 - 2.792 2.816 0.081
ENSG00000187778 E025 896.834216 1.517706e-04 1.216276e-01 2.222564e-01 12 49563487 49563546 60 - 2.818 2.837 0.064
ENSG00000187778 E026 1263.780712 9.261167e-05 3.532395e-01 4.974701e-01 12 49564481 49564590 110 - 2.977 2.984 0.022
ENSG00000187778 E027 758.053725 9.105688e-05 3.561675e-01 5.005554e-01 12 49564737 49564762 26 - 2.753 2.763 0.032
ENSG00000187778 E028 1136.994644 7.645446e-05 4.392983e-02 9.825707e-02 12 49564763 49564895 133 - 2.919 2.941 0.073
ENSG00000187778 E029 374.715856 2.278459e-03 5.274120e-01 6.604791e-01 12 49565529 49565529 1 - 2.442 2.461 0.062
ENSG00000187778 E030 1035.574594 6.067056e-04 2.342750e-01 3.674916e-01 12 49565530 49565667 138 - 2.918 2.893 -0.083
ENSG00000187778 E031 4.299798 4.542167e-03 8.969371e-01 9.381686e-01 12 49565668 49565679 12 - 0.620 0.637 0.074
ENSG00000187778 E032 1230.443456 4.856311e-04 7.807706e-09 9.816475e-08 12 49566077 49566215 139 - 3.049 2.954 -0.316
ENSG00000187778 E033 20.142572 1.236359e-02 2.130457e-08 2.471427e-07 12 49566216 49566262 47 - 1.585 1.057 -1.847
ENSG00000187778 E034 27.966552 2.673974e-02 6.262383e-08 6.617893e-07 12 49566263 49566390 128 - 1.735 1.177 -1.925
ENSG00000187778 E035 76.971122 1.993557e-02 1.999368e-15 7.260384e-14 12 49566391 49566721 331 - 2.205 1.571 -2.135
ENSG00000187778 E036 1058.814230 1.197780e-03 3.184582e-07 2.930252e-06 12 49566722 49566841 120 - 2.995 2.886 -0.364
ENSG00000187778 E037 28.349119 4.483220e-03 1.813025e-04 8.835976e-04 12 49567647 49567683 37 - 1.585 1.293 -1.006
ENSG00000187778 E038 36.227428 5.693238e-04 8.373218e-04 3.392534e-03 12 49567684 49567747 64 - 1.632 1.407 -0.771
ENSG00000187778 E039 22.078412 8.597974e-04 5.131546e-03 1.628620e-02 12 49567748 49567749 2 - 1.432 1.196 -0.824
ENSG00000187778 E040 22.708156 8.363440e-04 1.826511e-02 4.770944e-02 12 49567750 49567873 124 - 1.421 1.222 -0.693
ENSG00000187778 E041 738.096518 9.551054e-04 5.758272e-07 5.035717e-06 12 49568048 49568145 98 - 2.839 2.728 -0.367