ENSG00000187764

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356444 ENSG00000187764 HEK293_OSMI2_2hA HEK293_TMG_2hB SEMA4D protein_coding protein_coding 7.845761 6.064268 7.219354 0.1396937 0.2520344 0.251156 2.3100124 2.3356029 1.4793611 0.13000410 0.74045780 -0.6552652 0.28507083 0.38626667 0.21233333 -0.173933333 0.675953613 0.004364909 FALSE TRUE
ENST00000422704 ENSG00000187764 HEK293_OSMI2_2hA HEK293_TMG_2hB SEMA4D protein_coding protein_coding 7.845761 6.064268 7.219354 0.1396937 0.2520344 0.251156 2.2902112 1.4893472 2.6137366 0.34771340 0.70932636 0.8072884 0.30316250 0.24430000 0.35686667 0.112566667 0.610909809 0.004364909 FALSE TRUE
ENST00000486935 ENSG00000187764 HEK293_OSMI2_2hA HEK293_TMG_2hB SEMA4D protein_coding retained_intron 7.845761 6.064268 7.219354 0.1396937 0.2520344 0.251156 0.7056849 0.4654219 0.6177338 0.06572417 0.11797511 0.4009445 0.08506667 0.07633333 0.08480000 0.008466667 0.914393071 0.004364909   FALSE
ENST00000492386 ENSG00000187764 HEK293_OSMI2_2hA HEK293_TMG_2hB SEMA4D protein_coding retained_intron 7.845761 6.064268 7.219354 0.1396937 0.2520344 0.251156 0.6010745 0.8693963 0.3941213 0.07979751 0.06083148 -1.1217250 0.08142500 0.14406667 0.05456667 -0.089500000 0.004364909 0.004364909 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000187764 E001 0.0000000       9 89360787 89360790 4 -      
ENSG00000187764 E002 0.9921577 0.0126983184 4.055089e-01 5.491907e-01 9 89360791 89361600 810 - 0.211 0.372 1.113
ENSG00000187764 E003 0.7780993 0.0404324819 1.786728e-01 2.994826e-01 9 89361601 89361608 8 - 0.118 0.370 2.104
ENSG00000187764 E004 22.1914630 0.0008637871 2.411032e-03 8.495093e-03 9 89361609 89361978 370 - 1.213 1.464 0.874
ENSG00000187764 E005 20.1418949 0.0010952803 1.536772e-03 5.755514e-03 9 89361979 89362238 260 - 1.160 1.432 0.954
ENSG00000187764 E006 14.5479419 0.0036866859 1.589918e-01 2.737805e-01 9 89362239 89362428 190 - 1.099 1.254 0.550
ENSG00000187764 E007 10.7002463 0.0223956288 2.450712e-01 3.801056e-01 9 89363430 89363527 98 - 0.975 1.140 0.601
ENSG00000187764 E008 0.0000000       9 89363528 89363740 213 -      
ENSG00000187764 E009 13.5031694 0.0799776372 2.728867e-01 4.118541e-01 9 89363741 89363950 210 - 1.043 1.240 0.706
ENSG00000187764 E010 4.8037134 0.0087797891 6.800609e-01 7.840477e-01 9 89363951 89365654 1704 - 0.705 0.785 0.324
ENSG00000187764 E011 4.1212800 0.0040248784 8.145613e-01 8.825279e-01 9 89367123 89369519 2397 - 0.677 0.733 0.230
ENSG00000187764 E012 0.1482932 0.0412406619 4.801447e-01   9 89376386 89376832 447 - 0.000 0.126 9.606
ENSG00000187764 E013 8.5565132 0.0235663520 7.500109e-01 8.368021e-01 9 89376833 89377051 219 - 0.930 0.996 0.247
ENSG00000187764 E014 4.9706586 0.0032776069 4.986951e-01 6.351219e-01 9 89377052 89377234 183 - 0.801 0.733 -0.272
ENSG00000187764 E015 1.4328857 0.0103468275 7.282854e-01 8.207752e-01 9 89377235 89377236 2 - 0.352 0.430 0.435
ENSG00000187764 E016 354.7567370 0.0038637473 1.831960e-06 1.437039e-05 9 89377237 89379374 2138 - 2.461 2.618 0.522
ENSG00000187764 E017 40.7725592 0.0011860654 8.979724e-01 9.388771e-01 9 89379375 89379586 212 - 1.596 1.630 0.116
ENSG00000187764 E018 18.3354442 0.0010436006 9.158635e-01 9.507943e-01 9 89379587 89379629 43 - 1.275 1.293 0.063
ENSG00000187764 E019 10.7549291 0.0019399542 9.532554e-01 9.747631e-01 9 89381055 89381055 1 - 1.054 1.073 0.070
ENSG00000187764 E020 19.0221175 0.0018629588 9.262862e-01 9.575897e-01 9 89381056 89381098 43 - 1.282 1.301 0.065
ENSG00000187764 E021 1.5584534 0.0125328339 5.669332e-02 1.209314e-01 9 89381099 89381173 75 - 0.544 0.225 -1.886
ENSG00000187764 E022 31.0188530 0.0012748922 4.567822e-01 5.971501e-01 9 89381174 89381346 173 - 1.509 1.489 -0.069
ENSG00000187764 E023 10.3736902 0.0115040290 3.956645e-01 5.394735e-01 9 89381347 89381843 497 - 1.089 1.021 -0.248
ENSG00000187764 E024 36.2545570 0.0006284509 5.113803e-02 1.111983e-01 9 89386367 89386482 116 - 1.610 1.525 -0.289
ENSG00000187764 E025 0.1451727 0.0426952648 4.977316e-01   9 89386483 89386749 267 - 0.118 0.000 -10.213
ENSG00000187764 E026 0.3268771 0.0288183478 9.920321e-01   9 89387172 89387385 214 - 0.118 0.127 0.115
ENSG00000187764 E027 50.2616667 0.0036427530 8.079293e-03 2.398041e-02 9 89387386 89387608 223 - 1.767 1.647 -0.407
ENSG00000187764 E028 33.1534942 0.0022495959 4.509741e-01 5.919811e-01 9 89388636 89388792 157 - 1.541 1.521 -0.070
ENSG00000187764 E029 41.3263044 0.0005991576 1.041779e-01 1.968600e-01 9 89388872 89389047 176 - 1.654 1.594 -0.205
ENSG00000187764 E030 43.3033097 0.0005937527 4.490735e-05 2.559050e-04 9 89391264 89391415 152 - 1.731 1.542 -0.643
ENSG00000187764 E031 39.3519408 0.0005750192 8.859161e-04 3.564832e-03 9 89392423 89392536 114 - 1.681 1.525 -0.530
ENSG00000187764 E032 27.9681500 0.0021062671 1.325018e-01 2.375583e-01 9 89393562 89393630 69 - 1.500 1.427 -0.253
ENSG00000187764 E033 18.6537170 0.0027461584 5.230028e-01 6.567504e-01 9 89393631 89393655 25 - 1.309 1.285 -0.086
ENSG00000187764 E034 33.9499919 0.0006483026 2.893972e-01 4.300810e-01 9 89396737 89396835 99 - 1.560 1.525 -0.121
ENSG00000187764 E035 29.5488132 0.0058670624 5.634867e-01 6.909486e-01 9 89399276 89399338 63 - 1.496 1.482 -0.047
ENSG00000187764 E036 21.8712605 0.0058408752 4.303993e-01 5.730373e-01 9 89402871 89402895 25 - 1.383 1.347 -0.123
ENSG00000187764 E037 21.8401146 0.0009166888 2.023830e-01 3.292022e-01 9 89402896 89402924 29 - 1.394 1.329 -0.228
ENSG00000187764 E038 17.7447295 0.0010455855 2.912487e-01 4.321003e-01 9 89402925 89402944 20 - 1.303 1.245 -0.202
ENSG00000187764 E039 26.9245344 0.0008579659 3.671939e-01 5.115773e-01 9 89402945 89403016 72 - 1.465 1.432 -0.112
ENSG00000187764 E040 25.9073580 0.0007693857 2.450204e-01 3.800425e-01 9 89405351 89405453 103 - 1.455 1.404 -0.176
ENSG00000187764 E041 23.5424760 0.0008303148 6.253201e-01 7.414861e-01 9 89405454 89405560 107 - 1.394 1.387 -0.026
ENSG00000187764 E042 12.7325765 0.0017037000 7.875289e-01 8.639133e-01 9 89405561 89405601 41 - 1.141 1.142 0.004
ENSG00000187764 E043 21.4041536 0.0016973510 4.924876e-01 6.296586e-01 9 89405602 89405699 98 - 1.366 1.342 -0.083
ENSG00000187764 E044 0.0000000       9 89405795 89405926 132 -      
ENSG00000187764 E045 10.5860487 0.0263761944 9.416893e-01 9.673411e-01 9 89418056 89418118 63 - 1.054 1.072 0.064
ENSG00000187764 E046 0.0000000       9 89418119 89418233 115 -      
ENSG00000187764 E047 1.4351644 0.0113489599 3.330208e-01 4.766956e-01 9 89418363 89418437 75 - 0.459 0.304 -0.886
ENSG00000187764 E048 0.2214452 0.0385986190 4.772429e-01   9 89418438 89418833 396 - 0.000 0.127 9.627
ENSG00000187764 E049 0.0000000       9 89436322 89436578 257 -      
ENSG00000187764 E050 15.2117507 0.0013336244 9.761211e-02 1.868421e-01 9 89455888 89455953 66 - 1.268 1.152 -0.408
ENSG00000187764 E051 1.4361966 0.0094776129 9.501625e-02 1.829069e-01 9 89474539 89474623 85 - 0.504 0.225 -1.692
ENSG00000187764 E052 0.9223296 0.0132952607 9.564616e-02 1.838648e-01 9 89475485 89475550 66 - 0.409 0.127 -2.208
ENSG00000187764 E053 1.5627198 0.0120324615 5.653136e-02 1.206495e-01 9 89479572 89479890 319 - 0.544 0.225 -1.886
ENSG00000187764 E054 0.0000000       9 89497375 89497432 58 -      
ENSG00000187764 E055 6.2773772 0.0220134094 7.042723e-02 1.440581e-01 9 89497919 89498130 212 - 0.961 0.734 -0.881