ENSG00000187735

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000521604 ENSG00000187735 HEK293_OSMI2_2hA HEK293_TMG_2hB TCEA1 protein_coding protein_coding 51.42177 15.60811 99.36148 2.253409 1.62921 2.669612 40.109252 14.01283 77.87583 2.006116 3.464434 2.473584 0.85133750 0.8980667 0.7830667 -0.1150 4.748276e-04 4.520754e-16 FALSE TRUE
ENST00000640382 ENSG00000187735 HEK293_OSMI2_2hA HEK293_TMG_2hB TCEA1 protein_coding protein_coding 51.42177 15.60811 99.36148 2.253409 1.62921 2.669612 7.998281 0.00000 15.28237 0.000000 2.601580 10.578597 0.08782917 0.0000000 0.1546000 0.1546 4.520754e-16 4.520754e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000187735 E001 0.2214452 0.0443489278 6.302675e-02   8 53966552 53966555 4 - 0.000 0.258 12.261
ENSG00000187735 E002 1.3964532 0.0149961839 2.338856e-03 8.272300e-03 8 53966556 53966559 4 - 0.144 0.703 3.365
ENSG00000187735 E003 336.2417127 0.0002067393 6.150164e-52 4.161179e-49 8 53966560 53967021 462 - 2.316 2.684 1.226
ENSG00000187735 E004 404.8688524 0.0036207746 4.836655e-09 6.327968e-08 8 53967022 53967169 148 - 2.433 2.663 0.767
ENSG00000187735 E005 994.3431408 0.0016445427 2.864716e-08 3.238137e-07 8 53967170 53968112 943 - 2.843 2.983 0.465
ENSG00000187735 E006 0.8147197 0.0142461357 2.162187e-02 5.489043e-02 8 53970264 53970287 24 - 0.101 0.534 3.209
ENSG00000187735 E007 0.6695470 0.0171415328 7.438280e-03 2.235803e-02 8 53970288 53970293 6 - 0.053 0.534 4.209
ENSG00000187735 E008 1.5500318 0.0150401168 5.326906e-03 1.682140e-02 8 53970294 53970391 98 - 0.183 0.703 2.950
ENSG00000187735 E009 384.2829984 0.0001707988 8.872904e-10 1.328285e-08 8 53970392 53970463 72 - 2.475 2.344 -0.438
ENSG00000187735 E010 1.7286183 0.0079641873 7.579577e-01 8.426313e-01 8 53978523 53978697 175 - 0.338 0.418 0.457
ENSG00000187735 E011 472.1197357 0.0001153644 2.091222e-10 3.491152e-09 8 53979025 53979171 147 - 2.563 2.446 -0.391
ENSG00000187735 E012 361.7220771 0.0001479962 3.124140e-05 1.851121e-04 8 53984363 53984517 155 - 2.442 2.363 -0.264
ENSG00000187735 E013 0.2944980 0.4003089395 1.000000e+00   8 53986960 53986968 9 - 0.101 0.000 -11.577
ENSG00000187735 E014 264.9625172 0.0001589097 1.011185e-02 2.903703e-02 8 53986969 53987025 57 - 2.304 2.256 -0.158
ENSG00000187735 E015 384.5404282 0.0001242145 1.851064e-07 1.785169e-06 8 53988114 53988259 146 - 2.472 2.369 -0.345
ENSG00000187735 E016 0.4439371 0.0215736380 1.000000e+00 1.000000e+00 8 53993376 53993656 281 - 0.144 0.000 -13.262
ENSG00000187735 E017 0.1472490 0.0447987112 1.000000e+00   8 53993657 53993667 11 - 0.053 0.000 -11.465
ENSG00000187735 E018 205.7618033 0.0001832269 7.731965e-06 5.269435e-05 8 53993668 53993694 27 - 2.206 2.076 -0.437
ENSG00000187735 E019 166.4741933 0.0003058274 4.879700e-04 2.114176e-03 8 53993695 53993703 9 - 2.111 2.002 -0.366
ENSG00000187735 E020 244.8426151 0.0006572756 2.249212e-04 1.070001e-03 8 53993704 53993755 52 - 2.276 2.180 -0.321
ENSG00000187735 E021 0.0000000       8 53999625 53999944 320 -      
ENSG00000187735 E022 214.4542684 0.0008388617 6.582367e-03 2.014132e-02 8 53999945 54000009 65 - 2.215 2.146 -0.231
ENSG00000187735 E023 142.5616418 0.0010298141 1.947900e-02 5.037206e-02 8 54000010 54000050 41 - 2.039 1.965 -0.249
ENSG00000187735 E024 0.5975289 0.0347813569 6.846781e-01 7.876118e-01 8 54002892 54002940 49 - 0.183 0.000 -13.544
ENSG00000187735 E025 0.5954526 0.0172671820 6.828488e-01 7.862045e-01 8 54002941 54003086 146 - 0.183 0.000 -13.718
ENSG00000187735 E026 0.4439371 0.0215736380 1.000000e+00 1.000000e+00 8 54003087 54003092 6 - 0.144 0.000 -13.262
ENSG00000187735 E027 0.5879639 0.0222403394 5.787265e-01 7.037641e-01 8 54010102 54010110 9 - 0.144 0.257 1.039
ENSG00000187735 E028 166.6640660 0.0020799380 2.539216e-02 6.268448e-02 8 54010430 54010492 63 - 2.106 2.035 -0.238
ENSG00000187735 E029 3.2610500 0.0050799590 4.221263e-01 5.652923e-01 8 54021526 54021586 61 - 0.559 0.418 -0.698
ENSG00000187735 E030 4.5144954 0.0036884038 7.203470e-01 8.149702e-01 8 54021587 54021929 343 - 0.617 0.703 0.363
ENSG00000187735 E031 148.6446260 0.0051023645 2.287527e-02 5.748311e-02 8 54022063 54022265 203 - 2.061 1.961 -0.334
ENSG00000187735 E032 56.0830945 0.0354886989 3.543140e-01 4.985909e-01 8 54022266 54022456 191 - 1.642 1.555 -0.296