ENSG00000187730

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378585 ENSG00000187730 HEK293_OSMI2_2hA HEK293_TMG_2hB GABRD protein_coding protein_coding 3.313301 4.096066 3.16037 0.2764207 0.4731565 -0.3731055 1.33289836 1.2911159 1.3447536 0.19364067 0.09105604 0.05828095 0.38348333 0.3170667 0.44420000 0.12713333 0.49330784 0.02714053 FALSE TRUE
ENST00000638763 ENSG00000187730 HEK293_OSMI2_2hA HEK293_TMG_2hB GABRD protein_coding protein_coding 3.313301 4.096066 3.16037 0.2764207 0.4731565 -0.3731055 0.03765642 0.0000000 0.3012514 0.00000000 0.30125138 4.96000832 0.00917500 0.0000000 0.07340000 0.07340000 0.76005966 0.02714053 FALSE FALSE
ENST00000638771 ENSG00000187730 HEK293_OSMI2_2hA HEK293_TMG_2hB GABRD protein_coding protein_coding 3.313301 4.096066 3.16037 0.2764207 0.4731565 -0.3731055 0.95894432 1.3779206 0.9476190 0.09626894 0.11740761 -0.53540125 0.30210833 0.3367000 0.31920000 -0.01750000 0.90018664 0.02714053 FALSE TRUE
ENST00000639935 ENSG00000187730 HEK293_OSMI2_2hA HEK293_TMG_2hB GABRD protein_coding retained_intron 3.313301 4.096066 3.16037 0.2764207 0.4731565 -0.3731055 0.28550183 0.4781087 0.1580561 0.06125253 0.15805607 -1.53825994 0.07190833 0.1158333 0.03850000 -0.07733333 0.34537384 0.02714053 FALSE TRUE
ENST00000640030 ENSG00000187730 HEK293_OSMI2_2hA HEK293_TMG_2hB GABRD protein_coding protein_coding 3.313301 4.096066 3.16037 0.2764207 0.4731565 -0.3731055 0.31347524 0.6773979 0.1003824 0.15038111 0.05189311 -2.63863561 0.10522917 0.1665667 0.03033333 -0.13623333 0.02714053 0.02714053 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000187730 E001 0.3332198 0.0292976190 8.542365e-01   1 2019329 2019344 16 + 0.135 0.111 -0.332
ENSG00000187730 E002 1.2210941 0.0107013286 1.045309e-02 2.987069e-02 1 2019345 2019359 15 + 0.551 0.111 -3.139
ENSG00000187730 E003 4.3783527 0.0776689016 8.114096e-01 8.803449e-01 1 2019360 2019378 19 + 0.731 0.708 -0.094
ENSG00000187730 E004 5.2222172 0.0463114670 8.804598e-01 9.273316e-01 1 2019379 2019386 8 + 0.786 0.776 -0.040
ENSG00000187730 E005 5.7392046 0.0237867949 9.692638e-01 9.847894e-01 1 2019387 2019403 17 + 0.811 0.816 0.017
ENSG00000187730 E006 12.0040049 0.0077173118 6.714381e-01 7.776558e-01 1 2019404 2019483 80 + 1.116 1.082 -0.122
ENSG00000187730 E007 8.0924151 0.0233340796 8.732826e-01 9.225905e-01 1 2019484 2019491 8 + 0.919 0.950 0.118
ENSG00000187730 E008 0.0000000       1 2022315 2022391 77 +      
ENSG00000187730 E009 0.0000000       1 2023561 2023796 236 +      
ENSG00000187730 E010 0.0000000       1 2023797 2023890 94 +      
ENSG00000187730 E011 0.0000000       1 2023891 2024223 333 +      
ENSG00000187730 E012 0.0000000       1 2024270 2024941 672 +      
ENSG00000187730 E013 19.2049972 0.0068293167 7.420944e-01 8.311020e-01 1 2024942 2025054 113 + 1.268 1.306 0.133
ENSG00000187730 E014 11.2244599 0.0017899217 4.882493e-01 6.258448e-01 1 2025334 2025345 12 + 1.116 1.058 -0.207
ENSG00000187730 E015 15.7501702 0.0012413307 5.212105e-01 6.550904e-01 1 2025346 2025401 56 + 1.172 1.237 0.228
ENSG00000187730 E016 0.2214452 0.0389411525 6.079849e-01   1 2025402 2025432 31 + 0.000 0.111 10.189
ENSG00000187730 E017 11.9620770 0.0015167634 2.305441e-01 3.631095e-01 1 2025518 2025525 8 + 1.162 1.059 -0.371
ENSG00000187730 E018 36.8052202 0.0007145719 2.112030e-01 3.399240e-01 1 2025526 2025738 213 + 1.599 1.540 -0.201
ENSG00000187730 E019 1.5542096 0.0090760163 1.825136e-01 3.043692e-01 1 2025739 2025792 54 + 0.238 0.481 1.475
ENSG00000187730 E020 0.0000000       1 2026528 2026894 367 +      
ENSG00000187730 E021 0.1515154 0.0425723516 3.864269e-01   1 2026895 2027252 358 + 0.135 0.000 -11.575
ENSG00000187730 E022 0.0000000       1 2027253 2027576 324 +      
ENSG00000187730 E023 20.3198672 0.0013436407 5.650108e-03 1.768577e-02 1 2027577 2027628 52 + 1.424 1.229 -0.680
ENSG00000187730 E024 17.4736173 0.0015362175 8.509468e-04 3.441188e-03 1 2027629 2027659 31 + 1.393 1.139 -0.895
ENSG00000187730 E025 0.6600838 0.0415007175 8.073758e-01 8.776289e-01 1 2027660 2028070 411 + 0.238 0.199 -0.330
ENSG00000187730 E026 0.1451727 0.0429905085 3.866798e-01   1 2028071 2028154 84 + 0.135 0.000 -11.573
ENSG00000187730 E027 24.4989237 0.0119496550 4.463824e-02 9.953719e-02 1 2028155 2028287 133 + 1.486 1.328 -0.545
ENSG00000187730 E028 8.9041820 0.0023594972 4.202208e-01 5.634382e-01 1 2028288 2028292 5 + 1.036 0.960 -0.280
ENSG00000187730 E029 0.9190928 0.1898207292 8.605390e-01 9.140615e-01 1 2028919 2029110 192 + 0.238 0.277 0.291
ENSG00000187730 E030 21.6780334 0.0011875486 3.846795e-01 5.288365e-01 1 2029111 2029266 156 + 1.380 1.328 -0.181
ENSG00000187730 E031 0.5181333 0.0203885518 4.308789e-01 5.734891e-01 1 2029267 2029408 142 + 0.238 0.111 -1.330
ENSG00000187730 E032 17.0252491 0.0036625166 4.089044e-01 5.525177e-01 1 2029551 2029590 40 + 1.203 1.284 0.285
ENSG00000187730 E033 18.2672433 0.0010715620 9.944857e-01 1.000000e+00 1 2029591 2029619 29 + 1.268 1.278 0.038
ENSG00000187730 E034 33.2211315 0.0098406692 4.780053e-01 6.164595e-01 1 2029620 2029762 143 + 1.490 1.554 0.220
ENSG00000187730 E035 16.4309421 0.0012236861 2.864089e-01 4.267917e-01 1 2029763 2029982 220 + 1.172 1.272 0.351
ENSG00000187730 E036 72.8884584 0.0063219095 1.352184e-06 1.091839e-05 1 2029983 2030758 776 + 1.682 1.943 0.879