ENSG00000187676

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000343307 ENSG00000187676 HEK293_OSMI2_2hA HEK293_TMG_2hB B3GLCT protein_coding protein_coding 7.887946 3.088428 13.19745 0.3912898 0.30124 2.091743 5.623559 3.088428 8.600107 0.3912898 0.3034030 1.474495 0.8165750 1 0.6523667 -0.3476333 7.014420e-19 1.069745e-20 FALSE TRUE
MSTRG.8557.4 ENSG00000187676 HEK293_OSMI2_2hA HEK293_TMG_2hB B3GLCT protein_coding   7.887946 3.088428 13.19745 0.3912898 0.30124 2.091743 2.090714 0.000000 4.307609 0.0000000 0.3409795 8.754089 0.1613792 0 0.3258000 0.3258000 1.069745e-20 1.069745e-20 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000187676 E001 0.4482035 0.0269467879 4.716642e-01 6.107420e-01 13 31199972 31199974 3 + 0.187 0.000 -10.000
ENSG00000187676 E002 4.9093448 0.0032915524 7.133929e-04 2.946566e-03 13 31199975 31200021 47 + 0.829 0.201 -3.284
ENSG00000187676 E003 13.6433634 0.0085850434 6.835147e-06 4.719016e-05 13 31200022 31200154 133 + 1.216 0.597 -2.386
ENSG00000187676 E004 0.1515154 0.0431471411 1.000000e+00   13 31200881 31200930 50 + 0.072 0.000 -9.936
ENSG00000187676 E005 16.5280099 0.0052014939 1.001337e-02 2.879571e-02 13 31215051 31215100 50 + 1.252 0.993 -0.932
ENSG00000187676 E006 19.5154363 0.0163401818 5.022804e-02 1.095618e-01 13 31222952 31222991 40 + 1.309 1.106 -0.719
ENSG00000187676 E007 32.4610140 0.0197403202 2.667329e-01 4.049782e-01 13 31229185 31229294 110 + 1.499 1.400 -0.339
ENSG00000187676 E008 32.4955261 0.0007143291 1.224932e-01 2.235018e-01 13 31247023 31247099 77 + 1.499 1.411 -0.302
ENSG00000187676 E009 39.9519309 0.0005835524 1.168121e-01 2.154119e-01 13 31247855 31247966 112 + 1.586 1.508 -0.265
ENSG00000187676 E010 0.0000000       13 31260407 31260480 74 +      
ENSG00000187676 E011 53.2649816 0.0004363384 7.860431e-04 3.209465e-03 13 31260946 31261082 137 + 1.725 1.554 -0.582
ENSG00000187676 E012 43.8328240 0.0005165129 7.730826e-03 2.310321e-02 13 31269214 31269277 64 + 1.637 1.492 -0.495
ENSG00000187676 E013 57.2738971 0.0011372103 1.740804e-02 4.584046e-02 13 31274509 31274628 120 + 1.744 1.632 -0.378
ENSG00000187676 E014 40.6806370 0.0060257050 2.316266e-01 3.644023e-01 13 31276702 31276771 70 + 1.590 1.523 -0.229
ENSG00000187676 E015 0.1472490 0.0430783549 1.000000e+00   13 31283069 31283306 238 + 0.072 0.000 -9.935
ENSG00000187676 E016 54.5786838 0.0086024992 3.594425e-01 5.037752e-01 13 31284648 31284761 114 + 1.708 1.660 -0.164
ENSG00000187676 E017 52.1562106 0.0085676640 9.877185e-01 9.964020e-01 13 31286720 31286819 100 + 1.670 1.683 0.045
ENSG00000187676 E018 61.1777002 0.0176132375 8.372824e-01 8.982667e-01 13 31317566 31317685 120 + 1.741 1.737 -0.015
ENSG00000187676 E019 81.7424100 0.0003337723 5.164629e-02 1.120863e-01 13 31323751 31323895 145 + 1.883 1.819 -0.217
ENSG00000187676 E020 170.9019446 0.0002414347 2.394612e-01 3.734960e-01 13 31329501 31330121 621 + 2.187 2.175 -0.042
ENSG00000187676 E021 141.7792700 0.0002545293 1.619672e-04 8.004642e-04 13 31330122 31331008 887 + 2.063 2.201 0.462
ENSG00000187676 E022 79.4594189 0.0004794922 4.900537e-05 2.767354e-04 13 31331009 31331244 236 + 1.801 1.992 0.641
ENSG00000187676 E023 180.8468788 0.0099115939 1.363798e-04 6.875419e-04 13 31331245 31332276 1032 + 2.142 2.359 0.724