ENSG00000187672

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000288221 ENSG00000187672 HEK293_OSMI2_2hA HEK293_TMG_2hB ERC2 protein_coding protein_coding 1.418521 0.9988299 1.623997 0.1349472 0.2818392 0.6957222 0.39465527 0.19887164 0.4638872 0.02770880 0.05471252 1.1819272 0.27901250 0.2090 0.3002000 0.09120000 0.6611389573 0.0003122915 FALSE TRUE
ENST00000460849 ENSG00000187672 HEK293_OSMI2_2hA HEK293_TMG_2hB ERC2 protein_coding nonsense_mediated_decay 1.418521 0.9988299 1.623997 0.1349472 0.2818392 0.6957222 0.09828598 0.00000000 0.2604638 0.00000000 0.02567164 4.7573635 0.06145000 0.0000 0.1677333 0.16773333 0.0003122915 0.0003122915 TRUE TRUE
ENST00000472917 ENSG00000187672 HEK293_OSMI2_2hA HEK293_TMG_2hB ERC2 protein_coding processed_transcript 1.418521 0.9988299 1.623997 0.1349472 0.2818392 0.6957222 0.08541190 0.11291569 0.0000000 0.11291569 0.00000000 -3.6195971 0.05398333 0.1361 0.0000000 -0.13610000 0.7334863809 0.0003122915 FALSE FALSE
ENST00000477381 ENSG00000187672 HEK293_OSMI2_2hA HEK293_TMG_2hB ERC2 protein_coding processed_transcript 1.418521 0.9988299 1.623997 0.1349472 0.2818392 0.6957222 0.55550542 0.51087226 0.5963419 0.15256635 0.14026254 0.2192019 0.41994167 0.4984 0.3629000 -0.13550000 0.6190456871 0.0003122915 FALSE TRUE
ENST00000492584 ENSG00000187672 HEK293_OSMI2_2hA HEK293_TMG_2hB ERC2 protein_coding protein_coding 1.418521 0.9988299 1.623997 0.1349472 0.2818392 0.6957222 0.14109738 0.06065442 0.2746813 0.02193709 0.17330598 2.0104961 0.08599583 0.0578 0.1477333 0.08993333 0.7525426607 0.0003122915 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000187672 E001 10.2315224 0.082877838 0.0227214162 0.057174600 3 55508311 55509233 923 - 0.854 1.258 1.477
ENSG00000187672 E002 14.8262856 0.006744605 0.7659133470 0.848577629 3 55509234 55510562 1329 - 1.156 1.203 0.167
ENSG00000187672 E003 2.4701714 0.006629595 0.3808459680 0.525125376 3 55510563 55510775 213 - 0.454 0.613 0.747
ENSG00000187672 E004 1.6566122 0.009132097 0.1036196080 0.196009884 3 55510776 55510903 128 - 0.485 0.181 -1.991
ENSG00000187672 E005 2.6196130 0.005772954 0.2668779361 0.405138222 3 55510904 55511139 236 - 0.588 0.406 -0.891
ENSG00000187672 E006 1.6702280 0.043119903 0.4051028061 0.548778040 3 55511140 55511276 137 - 0.455 0.308 -0.843
ENSG00000187672 E007 0.9180738 0.019382073 0.0205181125 0.052583024 3 55606596 55606750 155 - 0.081 0.487 3.334
ENSG00000187672 E008 0.0000000       3 55606751 55606779 29 -      
ENSG00000187672 E009 1.8542111 0.009668205 0.0756784814 0.152591731 3 55606780 55606966 187 - 0.513 0.181 -2.128
ENSG00000187672 E010 0.0000000       3 55607873 55607910 38 -      
ENSG00000187672 E011 0.0000000       3 55610576 55610910 335 -      
ENSG00000187672 E012 0.0000000       3 55647037 55647226 190 -      
ENSG00000187672 E013 1.2617904 0.115923070 0.2984551093 0.439901543 3 55683794 55683859 66 - 0.261 0.484 1.314
ENSG00000187672 E014 3.5816068 0.004609605 0.5776056743 0.702836102 3 55699378 55699512 135 - 0.610 0.710 0.423
ENSG00000187672 E015 0.0000000       3 55699513 55699518 6 -      
ENSG00000187672 E016 2.4399970 0.006210165 0.6964947454 0.796826195 3 55734771 55734837 67 - 0.539 0.486 -0.255
ENSG00000187672 E017 2.5840238 0.006387804 0.9997358146 1.000000000 3 55734838 55734914 77 - 0.539 0.554 0.067
ENSG00000187672 E018 1.6940612 0.009565229 0.8786340230 0.926043679 3 55734915 55734918 4 - 0.422 0.406 -0.084
ENSG00000187672 E019 0.0000000       3 55766684 55766799 116 -      
ENSG00000187672 E020 4.2288809 0.009611582 0.6130425161 0.731842827 3 55888389 55888549 161 - 0.725 0.663 -0.256
ENSG00000187672 E021 4.6730335 0.004777567 0.0884597832 0.172769210 3 55950425 55950560 136 - 0.802 0.554 -1.048
ENSG00000187672 E022 0.0000000       3 55985977 55985988 12 -      
ENSG00000187672 E023 5.8824849 0.003122162 0.2459432547 0.381199167 3 55992057 55992250 194 - 0.855 0.710 -0.575
ENSG00000187672 E024 0.4031496 0.027212526 0.0513438843 0.111541137 3 56003099 56003134 36 - 0.000 0.309 11.597
ENSG00000187672 E025 3.8990087 0.004557949 0.5506686032 0.680276975 3 56007181 56007321 141 - 0.690 0.613 -0.331
ENSG00000187672 E026 3.9460372 0.004327298 0.4686142579 0.608021535 3 56010449 56010589 141 - 0.708 0.612 -0.407
ENSG00000187672 E027 2.6551126 0.005729620 0.9965888071 1.000000000 3 56018894 56019031 138 - 0.539 0.554 0.068
ENSG00000187672 E028 3.5552790 0.073604826 0.9365425734 0.964098218 3 56080817 56080984 168 - 0.631 0.618 -0.056
ENSG00000187672 E029 5.2182459 0.026480244 0.8632759847 0.915821372 3 56139509 56139676 168 - 0.772 0.753 -0.077
ENSG00000187672 E030 2.4189056 0.008833130 0.7058089103 0.804102380 3 56148977 56148987 11 - 0.539 0.486 -0.255
ENSG00000187672 E031 3.7873373 0.005244440 0.0395382056 0.090174011 3 56148988 56149132 145 - 0.741 0.406 -1.543
ENSG00000187672 E032 2.8851818 0.007831458 0.0081625315 0.024195255 3 56173446 56173520 75 - 0.671 0.181 -2.838
ENSG00000187672 E033 0.0000000       3 56173521 56173899 379 -      
ENSG00000187672 E034 8.2479350 0.025215449 0.0655500497 0.135959406 3 56296019 56296435 417 - 1.001 0.753 -0.952
ENSG00000187672 E035 3.6010954 0.004832830 0.0009284406 0.003714185 3 56433789 56434049 261 - 0.422 0.915 2.138
ENSG00000187672 E036 12.8992782 0.001547041 0.5193510165 0.653464209 3 56434351 56434581 231 - 1.097 1.174 0.278
ENSG00000187672 E037 18.4773297 0.004317617 0.4541439720 0.594809451 3 56434582 56435077 496 - 1.236 1.314 0.276
ENSG00000187672 E038 5.0982035 0.008547712 0.8777349541 0.925467251 3 56435078 56435147 70 - 0.757 0.752 -0.021
ENSG00000187672 E039 0.0000000       3 56467072 56467134 63 -      
ENSG00000187672 E040 4.6918448 0.012771839 0.7415631169 0.830693637 3 56468248 56468467 220 - 0.741 0.710 -0.128