ENSG00000187595

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000436535 ENSG00000187595 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF385C protein_coding protein_coding 0.4123248 0.7324006 0.3036478 0.05951593 0.05285437 -1.243053 0.09044345 0.19591110 0.00000000 0.08272671 0.00000000 -4.363950 0.25201250 0.25736667 0.0000000 -0.2573667 0.02338103 0.02338103 FALSE TRUE
ENST00000461831 ENSG00000187595 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF385C protein_coding protein_coding 0.4123248 0.7324006 0.3036478 0.05951593 0.05285437 -1.243053 0.18795365 0.43264277 0.09793158 0.05280066 0.09793158 -2.036026 0.38177917 0.60036667 0.2455333 -0.3548333 0.36800213 0.02338103 FALSE FALSE
ENST00000618554 ENSG00000187595 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF385C protein_coding protein_coding 0.4123248 0.7324006 0.3036478 0.05951593 0.05285437 -1.243053 0.04378193 0.00000000 0.00000000 0.00000000 0.00000000 0.000000 0.09664583 0.00000000 0.0000000 0.0000000   0.02338103 FALSE TRUE
ENST00000649819 ENSG00000187595 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF385C protein_coding protein_coding 0.4123248 0.7324006 0.3036478 0.05951593 0.05285437 -1.243053 0.05774537 0.06631678 0.16401204 0.06631678 0.08378817 1.189115 0.19174583 0.09083333 0.6440667 0.5532333 0.37886724 0.02338103 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000187595 E001 0.3634088 0.031998824 0.69426874   17 42025576 42025624 49 - 0.000 0.143 8.470
ENSG00000187595 E002 25.0364659 0.041159753 0.47584577 0.61452748 17 42025625 42027133 1509 - 1.288 1.356 0.236
ENSG00000187595 E003 0.6652806 0.020770198 1.00000000 1.00000000 17 42027618 42027632 15 - 0.188 0.200 0.109
ENSG00000187595 E004 1.5938512 0.020269608 0.31393801 0.45659378 17 42027633 42027728 96 - 0.501 0.336 -0.894
ENSG00000187595 E005 0.3686942 0.029396325 0.43366057 0.57606629 17 42027729 42028049 321 - 0.188 0.078 -1.472
ENSG00000187595 E006 2.5097469 0.007243862 0.61548238 0.73374293 17 42028050 42028246 197 - 0.420 0.524 0.523
ENSG00000187595 E007 0.2965864 0.228319982 0.76236886   17 42028567 42028689 123 - 0.000 0.140 10.000
ENSG00000187595 E008 3.2742289 0.005472879 0.29844321 0.43988815 17 42028783 42029073 291 - 0.420 0.615 0.940
ENSG00000187595 E009 0.9899927 0.015623395 0.12107541 0.22147590 17 42029074 42029076 3 - 0.000 0.336 11.365
ENSG00000187595 E010 2.5077723 0.007243862 0.48417980 0.62219878 17 42031619 42031784 166 - 0.570 0.470 -0.475
ENSG00000187595 E011 1.8445680 0.010998239 0.41627238 0.55963917 17 42034225 42034335 111 - 0.501 0.374 -0.668
ENSG00000187595 E012 0.9139106 0.314431271 0.02421062 0.06024576 17 42037737 42037885 149 - 0.569 0.078 -3.786
ENSG00000187595 E013 0.0000000       17 42038014 42038026 13 -      
ENSG00000187595 E014 0.0000000       17 42061239 42062806 1568 -      
ENSG00000187595 E015 0.0000000       17 42062807 42063058 252 -      
ENSG00000187595 E016 0.0000000       17 42065101 42065365 265 -      
ENSG00000187595 E017 0.0000000       17 42098410 42098479 70 -