ENSG00000187555

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000344836 ENSG00000187555 HEK293_OSMI2_2hA HEK293_TMG_2hB USP7 protein_coding protein_coding 53.18825 37.14203 69.27516 1.429885 1.729403 0.8991055 1.633062 0.1369732 4.61097795 0.1369732 0.09450676 4.9745731 0.02593750 0.003433333 0.0667333333 0.0633000 8.220807e-03 3.368895e-12 FALSE TRUE
ENST00000381886 ENSG00000187555 HEK293_OSMI2_2hA HEK293_TMG_2hB USP7 protein_coding protein_coding 53.18825 37.14203 69.27516 1.429885 1.729403 0.8991055 20.108729 7.6635867 31.66499659 2.0629339 2.37470641 2.0453715 0.34681250 0.205633333 0.4561000000 0.2504667 2.999020e-02 3.368895e-12 FALSE TRUE
ENST00000563961 ENSG00000187555 HEK293_OSMI2_2hA HEK293_TMG_2hB USP7 protein_coding nonsense_mediated_decay 53.18825 37.14203 69.27516 1.429885 1.729403 0.8991055 18.024110 17.6675671 20.04108517 0.3087259 0.80099236 0.1817606 0.35894167 0.477200000 0.2893333333 -0.1878667 1.688372e-07 3.368895e-12 FALSE TRUE
ENST00000673704 ENSG00000187555 HEK293_OSMI2_2hA HEK293_TMG_2hB USP7 protein_coding protein_coding 53.18825 37.14203 69.27516 1.429885 1.729403 0.8991055 3.655418 8.7288955 0.04695838 1.7539340 0.04695838 -7.2613991 0.08995833 0.235100000 0.0006666667 -0.2344333 3.368895e-12 3.368895e-12 FALSE TRUE
MSTRG.12015.5 ENSG00000187555 HEK293_OSMI2_2hA HEK293_TMG_2hB USP7 protein_coding   53.18825 37.14203 69.27516 1.429885 1.729403 0.8991055 2.996711 1.7095680 3.62046942 0.3784720 1.17109761 1.0781099 0.05507500 0.045433333 0.0531333333 0.0077000 9.717142e-01 3.368895e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000187555 E001 110.6170887 0.0183114172 3.784664e-12 8.446145e-11 16 8892097 8892771 675 - 1.707 2.268 1.884
ENSG00000187555 E002 437.9112486 0.0025670557 2.126213e-27 2.856770e-25 16 8892772 8893363 592 - 2.455 2.795 1.132
ENSG00000187555 E003 556.0328392 0.0032638554 1.805641e-13 4.953993e-12 16 8893364 8893787 424 - 2.617 2.863 0.820
ENSG00000187555 E004 430.4881146 0.0029598748 1.093296e-14 3.574761e-13 16 8893788 8893939 152 - 2.498 2.757 0.863
ENSG00000187555 E005 569.4532011 0.0018465193 2.702446e-20 1.785113e-18 16 8893940 8894104 165 - 2.625 2.874 0.828
ENSG00000187555 E006 486.3114738 0.0014976429 3.200080e-18 1.655052e-16 16 8894550 8894640 91 - 2.569 2.796 0.756
ENSG00000187555 E007 442.1051991 0.0020196181 5.610688e-07 4.916638e-06 16 8894784 8894855 72 - 2.570 2.721 0.503
ENSG00000187555 E008 313.0056652 0.0023381008 1.142801e-03 4.446946e-03 16 8895031 8895044 14 - 2.440 2.554 0.382
ENSG00000187555 E009 287.3041035 0.0018027828 7.540302e-04 3.094174e-03 16 8895045 8895058 14 - 2.404 2.517 0.376
ENSG00000187555 E010 310.3731934 0.0019877392 4.394891e-04 1.926242e-03 16 8895059 8895083 25 - 2.435 2.553 0.393
ENSG00000187555 E011 388.4793598 0.0007968428 1.438220e-08 1.721420e-07 16 8895084 8895150 67 - 2.520 2.661 0.469
ENSG00000187555 E012 413.2253376 0.0005779591 3.401807e-11 6.488744e-10 16 8895642 8895741 100 - 2.542 2.693 0.504
ENSG00000187555 E013 393.9036048 0.0005815811 1.839464e-11 3.667062e-10 16 8896999 8897063 65 - 2.518 2.674 0.517
ENSG00000187555 E014 334.7689600 0.0018568418 1.109487e-04 5.721762e-04 16 8897064 8897099 36 - 2.463 2.586 0.408
ENSG00000187555 E015 0.6976476 0.1096707903 7.318302e-01 8.234109e-01 16 8897100 8897254 155 - 0.187 0.253 0.552
ENSG00000187555 E016 426.6938398 0.0002611222 2.181479e-05 1.340495e-04 16 8898360 8898437 78 - 2.585 2.677 0.308
ENSG00000187555 E017 0.5546650 0.0212438485 3.857495e-01 5.299350e-01 16 8898438 8898530 93 - 0.104 0.252 1.541
ENSG00000187555 E018 370.0508075 0.0002734769 8.142900e-08 8.416432e-07 16 8898531 8898593 63 - 2.510 2.630 0.399
ENSG00000187555 E019 316.3568647 0.0001537948 8.342298e-09 1.043184e-07 16 8898594 8898639 46 - 2.436 2.568 0.439
ENSG00000187555 E020 0.9545949 0.0195782722 6.848539e-01 7.877180e-01 16 8898640 8898720 81 - 0.318 0.252 -0.460
ENSG00000187555 E021 250.0979491 0.0001647946 2.350788e-07 2.223192e-06 16 8899121 8899149 29 - 2.334 2.467 0.441
ENSG00000187555 E022 269.2127205 0.0014110349 4.163881e-03 1.360271e-02 16 8899150 8899174 25 - 2.386 2.479 0.311
ENSG00000187555 E023 216.3990932 0.0005014189 5.873976e-02 1.244709e-01 16 8899175 8899188 14 - 2.305 2.368 0.210
ENSG00000187555 E024 4.4033993 0.0608786414 8.162605e-02 1.621013e-01 16 8899307 8899579 273 - 0.840 0.529 -1.317
ENSG00000187555 E025 1.7116915 0.3860713036 9.645029e-01 9.816260e-01 16 8899580 8899603 24 - 0.459 0.408 -0.267
ENSG00000187555 E026 466.8481566 0.0003599710 8.886735e-01 9.328217e-01 16 8899604 8899757 154 - 2.663 2.679 0.056
ENSG00000187555 E027 8.4559196 0.0028384571 8.494644e-08 8.743737e-07 16 8899758 8900131 374 - 1.169 0.471 -2.812
ENSG00000187555 E028 399.0361728 0.0001454231 1.385527e-01 2.460941e-01 16 8900530 8900630 101 - 2.608 2.595 -0.043
ENSG00000187555 E029 10.5661890 0.0016303006 3.711027e-03 1.232954e-02 16 8900631 8900920 290 - 1.177 0.884 -1.075
ENSG00000187555 E030 336.2361888 0.0001883681 6.859147e-02 1.410355e-01 16 8900990 8901057 68 - 2.538 2.515 -0.075
ENSG00000187555 E031 360.6318153 0.0001458824 2.102773e-02 5.364740e-02 16 8901142 8901234 93 - 2.571 2.541 -0.101
ENSG00000187555 E032 3.9974063 0.0039370474 1.674846e-02 4.438351e-02 16 8901933 8902081 149 - 0.824 0.471 -1.532
ENSG00000187555 E033 283.1303141 0.0001589506 2.765714e-01 4.160265e-01 16 8902082 8902138 57 - 2.457 2.447 -0.032
ENSG00000187555 E034 186.6066524 0.0005973844 3.988961e-01 5.426485e-01 16 8902139 8902142 4 - 2.276 2.265 -0.035
ENSG00000187555 E035 287.9471434 0.0014751533 1.310842e-02 3.616092e-02 16 8902143 8902187 45 - 2.484 2.427 -0.188
ENSG00000187555 E036 2.8871564 0.0053843472 1.675262e-02 4.439224e-02 16 8902188 8902380 193 - 0.726 0.338 -1.877
ENSG00000187555 E037 340.8169402 0.0030286150 8.458822e-03 2.493385e-02 16 8902381 8902482 102 - 2.564 2.489 -0.249
ENSG00000187555 E038 383.2334290 0.0001801674 1.585027e-10 2.703022e-09 16 8903268 8903402 135 - 2.629 2.520 -0.363
ENSG00000187555 E039 331.3179141 0.0001610578 2.673635e-07 2.500060e-06 16 8904435 8904524 90 - 2.559 2.468 -0.303
ENSG00000187555 E040 270.7825818 0.0001933486 2.631626e-07 2.463941e-06 16 8904525 8904565 41 - 2.475 2.373 -0.342
ENSG00000187555 E041 454.4100826 0.0001225767 3.821456e-18 1.957187e-16 16 8905187 8905331 145 - 2.715 2.578 -0.458
ENSG00000187555 E042 441.2722793 0.0001970322 3.216906e-19 1.879806e-17 16 8906426 8906582 157 - 2.706 2.557 -0.499
ENSG00000187555 E043 323.2315655 0.0018190637 5.517144e-05 3.075493e-04 16 8908341 8908450 110 - 2.553 2.449 -0.346
ENSG00000187555 E044 273.2080886 0.0025036686 7.205631e-04 2.972487e-03 16 8910745 8910827 83 - 2.478 2.381 -0.324
ENSG00000187555 E045 261.7947670 0.0016405416 5.819985e-07 5.085695e-06 16 8915254 8915344 91 - 2.475 2.338 -0.454
ENSG00000187555 E046 263.2747420 0.0015718896 2.954243e-08 3.329006e-07 16 8915445 8915525 81 - 2.482 2.331 -0.504
ENSG00000187555 E047 250.3461466 0.0072206154 3.953443e-06 2.879538e-05 16 8916502 8916556 55 - 2.480 2.271 -0.699
ENSG00000187555 E048 342.6027696 0.0054728919 3.616287e-07 3.289928e-06 16 8917026 8917156 131 - 2.613 2.413 -0.665
ENSG00000187555 E049 317.0808123 0.0046701132 1.968769e-07 1.888398e-06 16 8919031 8919139 109 - 2.577 2.384 -0.644
ENSG00000187555 E050 203.4734158 0.0037947110 5.965155e-07 5.198642e-06 16 8920359 8920404 46 - 2.383 2.197 -0.622
ENSG00000187555 E051 173.1851759 0.0014551689 3.072931e-07 2.836610e-06 16 8920405 8920442 38 - 2.303 2.147 -0.523
ENSG00000187555 E052 119.9255408 0.0012921406 1.181874e-05 7.722908e-05 16 8920443 8920447 5 - 2.143 1.994 -0.499
ENSG00000187555 E053 116.9729129 0.0005764605 1.111928e-06 9.141266e-06 16 8921157 8921159 3 - 2.135 1.978 -0.526
ENSG00000187555 E054 139.9349444 0.0005924209 4.639788e-06 3.327884e-05 16 8921160 8921176 17 - 2.203 2.069 -0.451
ENSG00000187555 E055 233.3176546 0.0024843019 2.889898e-08 3.263098e-07 16 8921177 8921295 119 - 2.439 2.262 -0.591
ENSG00000187555 E056 234.2205501 0.0027318443 6.448743e-11 1.173804e-09 16 8923215 8923306 92 - 2.455 2.239 -0.723
ENSG00000187555 E057 161.5829203 0.0053800971 2.607685e-09 3.580101e-08 16 8923307 8923353 47 - 2.311 2.048 -0.880
ENSG00000187555 E058 143.2132149 0.0045734506 9.833921e-10 1.460495e-08 16 8923354 8923413 60 - 2.259 1.994 -0.888
ENSG00000187555 E059 4.0976519 0.0039121616 1.262913e-01 2.289906e-01 16 8929369 8929543 175 - 0.787 0.574 -0.901
ENSG00000187555 E060 153.3933973 0.0002489573 4.968660e-24 4.948989e-22 16 8930293 8930385 93 - 2.299 2.001 -0.996
ENSG00000187555 E061 75.6510173 0.0019157258 5.815592e-16 2.267247e-14 16 8930386 8930397 12 - 2.018 1.637 -1.284
ENSG00000187555 E062 0.0000000       16 8935643 8935800 158 -      
ENSG00000187555 E063 0.0000000       16 8935801 8935856 56 -      
ENSG00000187555 E064 0.0000000       16 8936583 8936729 147 -      
ENSG00000187555 E065 0.1817044 0.0399424396 3.512199e-01   16 8949554 8949653 100 - 0.000 0.144 11.123
ENSG00000187555 E066 0.0000000       16 8956308 8956380 73 -      
ENSG00000187555 E067 0.1482932 0.0413582149 3.531837e-01   16 8962476 8962612 137 - 0.000 0.143 11.119
ENSG00000187555 E068 91.9745159 0.0032968719 7.045808e-24 6.901795e-22 16 8963207 8963297 91 - 2.128 1.629 -1.681
ENSG00000187555 E069 38.1506110 0.0028516676 1.688253e-25 1.945465e-23 16 8963298 8963308 11 - 1.798 1.018 -2.715
ENSG00000187555 E070 50.0698756 0.0066199053 6.974813e-30 1.165218e-27 16 8963309 8963463 155 - 1.925 1.034 -3.082
ENSG00000187555 E071 27.2489144 0.0139098454 7.718672e-25 8.346343e-23 16 8963464 8963734 271 - 1.695 0.410 -4.952
ENSG00000187555 E072 19.3438833 0.0277042860 6.934720e-15 2.341404e-13 16 8963735 8964012 278 - 1.544 0.411 -4.432
ENSG00000187555 E073 0.1451727 0.0431443890 6.695566e-01   16 8964394 8964514 121 - 0.104 0.000 -10.318
ENSG00000187555 E074 0.4418608 0.0257904328 1.528322e-01 2.655026e-01 16 8975094 8975328 235 - 0.258 0.000 -11.904