ENSG00000187514

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341369 ENSG00000187514 HEK293_OSMI2_2hA HEK293_TMG_2hB PTMA protein_coding protein_coding 1795.388 2032.271 1999.292 281.8104 66.64753 -0.02360342 165.4032 188.42387 175.1247 28.25115 1.112349 -0.1055932 0.09234583 0.09246667 0.08776667 -0.00470000 6.652724e-01 8.724926e-10 FALSE  
ENST00000409115 ENSG00000187514 HEK293_OSMI2_2hA HEK293_TMG_2hB PTMA protein_coding protein_coding 1795.388 2032.271 1999.292 281.8104 66.64753 -0.02360342 1507.8907 1800.72891 1664.4156 253.26082 66.174804 -0.1135646 0.83839583 0.88566667 0.83220000 -0.05346667 1.585958e-04 8.724926e-10 FALSE  
ENST00000468027 ENSG00000187514 HEK293_OSMI2_2hA HEK293_TMG_2hB PTMA protein_coding retained_intron 1795.388 2032.271 1999.292 281.8104 66.64753 -0.02360342 92.8804 18.65372 132.2452 3.70798 13.038636 2.8250165 0.05086250 0.00950000 0.06626667 0.05676667 8.724926e-10 8.724926e-10 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000187514 E001 57.709853 1.586921e-01 1.768729e-03 6.499798e-03 2 231706895 231707228 334 + 1.187 1.953 2.625
ENSG00000187514 E002 2.678743 1.092800e-01 7.475171e-01 8.350017e-01 2 231707630 231707683 54 + 0.612 0.536 -0.344
ENSG00000187514 E003 28.665490 1.901843e-01 4.780257e-01 6.164774e-01 2 231707684 231707835 152 + 1.572 1.372 -0.688
ENSG00000187514 E004 9.869254 7.450078e-03 2.701530e-01 4.087345e-01 2 231708516 231708524 9 + 0.950 1.082 0.485
ENSG00000187514 E005 17.426965 4.084886e-03 2.729882e-01 4.119580e-01 2 231708525 231708529 5 + 1.199 1.303 0.366
ENSG00000187514 E006 97.194421 3.288463e-03 5.812111e-01 7.057791e-01 2 231708530 231708535 6 + 1.974 2.002 0.095
ENSG00000187514 E007 13260.171010 1.166660e-03 7.341905e-05 3.966186e-04 2 231708536 231708713 178 + 4.155 4.089 -0.219
ENSG00000187514 E008 11861.260960 3.003350e-04 2.838650e-17 1.307180e-15 2 231708714 231708751 38 + 4.110 4.038 -0.239
ENSG00000187514 E009 42.575750 2.964516e-02 1.761841e-01 2.962627e-01 2 231709781 231710301 521 + 1.710 1.563 -0.501
ENSG00000187514 E010 7.383050 3.522090e-02 1.957469e-02 5.057231e-02 2 231710427 231710490 64 + 1.080 0.748 -1.263
ENSG00000187514 E011 31.205196 1.752654e-03 7.986591e-01 8.715241e-01 2 231710491 231710584 94 + 1.490 1.514 0.082
ENSG00000187514 E012 31.819092 1.527765e-02 3.915373e-01 5.354554e-01 2 231710585 231710676 92 + 1.471 1.539 0.232
ENSG00000187514 E013 66.012706 4.664582e-03 1.582074e-01 2.727299e-01 2 231711131 231711347 217 + 1.777 1.855 0.262
ENSG00000187514 E014 14654.705641 2.154945e-04 1.513181e-18 8.155552e-17 2 231711348 231711419 72 + 4.197 4.135 -0.206
ENSG00000187514 E015 39.893565 3.125525e-03 3.581206e-01 5.024987e-01 2 231711420 231711524 105 + 1.637 1.586 -0.174
ENSG00000187514 E016 92.283162 4.370041e-03 2.473249e-04 1.164156e-03 2 231711525 231711886 362 + 2.059 1.882 -0.596
ENSG00000187514 E017 922.698017 1.041955e-03 9.790406e-02 1.873252e-01 2 231711887 231711889 3 + 2.980 2.951 -0.095
ENSG00000187514 E018 18121.966601 4.908305e-05 2.350711e-09 3.253472e-08 2 231711890 231711983 94 + 4.267 4.249 -0.059
ENSG00000187514 E019 10260.131077 1.116200e-03 5.121472e-01 6.470690e-01 2 231712443 231712451 9 + 4.000 4.012 0.042
ENSG00000187514 E020 13889.958916 4.619214e-04 8.032102e-01 8.747321e-01 2 231712452 231712516 65 + 4.136 4.141 0.016
ENSG00000187514 E021 80.463690 1.926676e-02 1.860587e-01 3.088134e-01 2 231712517 231712675 159 + 1.960 1.859 -0.339
ENSG00000187514 E022 23878.823302 1.047514e-04 1.883640e-45 9.057103e-43 2 231712804 231713313 510 + 4.336 4.402 0.219
ENSG00000187514 E023 6632.726018 1.018606e-03 1.162146e-42 4.684363e-40 2 231713314 231713551 238 + 3.679 3.898 0.726