ENSG00000187243

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000335504 ENSG00000187243 HEK293_OSMI2_2hA HEK293_TMG_2hB MAGED4B protein_coding protein_coding 39.32349 67.29441 26.96473 5.158232 1.063122 -1.319093 20.0997396 30.312118 17.139820 5.7025722 1.752339 -0.8221771 0.49839167 0.4490667 0.63346667 0.18440000 2.032590e-01 2.550356e-36 FALSE TRUE
ENST00000360134 ENSG00000187243 HEK293_OSMI2_2hA HEK293_TMG_2hB MAGED4B protein_coding protein_coding 39.32349 67.29441 26.96473 5.158232 1.063122 -1.319093 2.1724391 6.077964 0.000000 0.9429911 0.000000 -9.2498160 0.03886667 0.0930000 0.00000000 -0.09300000 5.294294e-16 2.550356e-36 FALSE TRUE
ENST00000470594 ENSG00000187243 HEK293_OSMI2_2hA HEK293_TMG_2hB MAGED4B protein_coding retained_intron 39.32349 67.29441 26.96473 5.158232 1.063122 -1.319093 0.9939438 0.000000 2.072522 0.0000000 0.146772 7.7021879 0.03452083 0.0000000 0.07723333 0.07723333 2.550356e-36 2.550356e-36 FALSE TRUE
ENST00000490581 ENSG00000187243 HEK293_OSMI2_2hA HEK293_TMG_2hB MAGED4B protein_coding nonsense_mediated_decay 39.32349 67.29441 26.96473 5.158232 1.063122 -1.319093 7.9595742 25.300800 0.000000 5.6213216 0.000000 -11.3055374 0.14552500 0.3790000 0.00000000 -0.37900000 6.395172e-18 2.550356e-36 FALSE TRUE
ENST00000497164 ENSG00000187243 HEK293_OSMI2_2hA HEK293_TMG_2hB MAGED4B protein_coding protein_coding 39.32349 67.29441 26.96473 5.158232 1.063122 -1.319093 5.6455979 4.422329 5.738625 2.3421527 0.329002 0.3751520 0.20026667 0.0617000 0.21433333 0.15263333 4.508186e-01 2.550356e-36 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000187243 E001 0.0000000       X 52061827 52061838 12 -      
ENSG00000187243 E002 1.1363854 0.254441725 0.652715099 0.763382067 X 52061839 52061982 144 - 0.236 0.347 0.762
ENSG00000187243 E003 1.4663830 0.011236839 0.271685131 0.410452583 X 52061983 52062038 56 - 0.236 0.441 1.281
ENSG00000187243 E004 0.0000000       X 52062222 52062233 12 -      
ENSG00000187243 E005 0.8783198 0.013696863 0.266554422 0.404773603 X 52062234 52062251 18 - 0.134 0.337 1.694
ENSG00000187243 E006 1.7274803 0.008895069 0.002432526 0.008559816 X 52062252 52062365 114 - 0.000 0.561 14.324
ENSG00000187243 E007 3.9603355 0.039717988 0.022303967 0.056303646 X 52062366 52062555 190 - 0.389 0.801 1.877
ENSG00000187243 E008 2.1327234 0.007623787 0.862169960 0.915126962 X 52062556 52062664 109 - 0.501 0.484 -0.085
ENSG00000187243 E009 1.8370794 0.008035087 0.261050590 0.398665489 X 52062987 52063101 115 - 0.319 0.524 1.107
ENSG00000187243 E010 0.1451727 0.043115416 0.385921365   X 52063102 52063346 245 - 0.134 0.000 -12.820
ENSG00000187243 E011 0.1515154 0.042779975 0.385564103   X 52063347 52063702 356 - 0.134 0.000 -12.821
ENSG00000187243 E012 0.1515154 0.042779975 0.385564103   X 52063703 52063750 48 - 0.134 0.000 -12.821
ENSG00000187243 E013 0.1515154 0.042779975 0.385564103   X 52063751 52063773 23 - 0.134 0.000 -12.821
ENSG00000187243 E014 0.2966881 0.029078516 0.140855836   X 52063774 52064046 273 - 0.237 0.000 -13.655
ENSG00000187243 E015 0.7686361 0.060872673 0.866563583 0.918103210 X 52064047 52064109 63 - 0.236 0.272 0.270
ENSG00000187243 E016 0.0000000       X 52064110 52064447 338 -      
ENSG00000187243 E017 0.4741261 0.021868225 0.429890326 0.572539352 X 52064448 52064500 53 - 0.236 0.111 -1.306
ENSG00000187243 E018 0.7707125 0.016273270 0.867559349 0.918838267 X 52064501 52064543 43 - 0.237 0.273 0.276
ENSG00000187243 E019 0.6203429 0.028552251 0.807876722 0.877931632 X 52064629 52064708 80 - 0.236 0.200 -0.308
ENSG00000187243 E020 0.0000000       X 52065169 52065329 161 -      
ENSG00000187243 E021 0.8114974 0.099724317 0.302009545 0.443840788 X 52065330 52065421 92 - 0.134 0.334 1.680
ENSG00000187243 E022 0.0000000       X 52065422 52065809 388 -      
ENSG00000187243 E023 0.2214452 0.039091580 0.609681843   X 52065810 52065889 80 - 0.000 0.112 11.775
ENSG00000187243 E024 0.0000000       X 52066045 52066082 38 -      
ENSG00000187243 E025 0.3697384 0.025590298 0.275397659 0.414695537 X 52066083 52066146 64 - 0.000 0.200 12.634
ENSG00000187243 E026 1.1092152 0.112592599 0.026634069 0.065233054 X 52066250 52066453 204 - 0.000 0.441 13.808
ENSG00000187243 E027 2.3604095 0.006830343 0.243747097 0.378588169 X 52066454 52066864 411 - 0.389 0.594 1.014
ENSG00000187243 E028 1.8894926 0.012223464 0.263613896 0.401528109 X 52066865 52067001 137 - 0.319 0.524 1.108
ENSG00000187243 E029 0.8909922 0.022169089 0.269079712 0.407551751 X 52067002 52067009 8 - 0.134 0.337 1.693
ENSG00000187243 E030 4.7627395 0.004059470 0.794505741 0.868721297 X 52067010 52067269 260 - 0.728 0.776 0.195
ENSG00000187243 E031 14.1912047 0.001615738 0.603845646 0.724520695 X 52067270 52067390 121 - 1.179 1.152 -0.099
ENSG00000187243 E032 11.5718149 0.001845447 0.036042563 0.083666071 X 52067391 52067401 11 - 1.179 1.003 -0.637
ENSG00000187243 E033 16.0304648 0.002382086 0.192106824 0.316393065 X 52067402 52067485 84 - 1.264 1.178 -0.305
ENSG00000187243 E034 3.2764956 0.005210399 0.537232958 0.668843011 X 52067486 52067698 213 - 0.548 0.655 0.472
ENSG00000187243 E035 7.1890294 0.003210397 0.933067303 0.961825407 X 52067963 52068173 211 - 0.896 0.920 0.088
ENSG00000187243 E036 3.3161518 0.005257905 0.428633575 0.571367672 X 52068174 52068203 30 - 0.697 0.594 -0.446
ENSG00000187243 E037 1.7359034 0.008133366 0.475223416 0.613958527 X 52068204 52068224 21 - 0.501 0.391 -0.571
ENSG00000187243 E038 5.6109736 0.004109844 0.360887781 0.505270098 X 52068225 52068263 39 - 0.876 0.776 -0.391
ENSG00000187243 E039 6.0485785 0.003311607 0.790889637 0.866275219 X 52069130 52069219 90 - 0.855 0.836 -0.073