ENSG00000187239

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000420781 ENSG00000187239 HEK293_OSMI2_2hA HEK293_TMG_2hB FNBP1 protein_coding protein_coding 12.06569 11.83586 12.40044 0.8263673 0.2063067 0.06717167 7.6320329 8.1658977 7.2079292 1.28111969 0.4050521 -0.1797921 0.63352083 0.69053333 0.58190000 -0.10863333 6.549454e-01 1.687445e-09 FALSE TRUE
ENST00000443566 ENSG00000187239 HEK293_OSMI2_2hA HEK293_TMG_2hB FNBP1 protein_coding protein_coding 12.06569 11.83586 12.40044 0.8263673 0.2063067 0.06717167 1.3623281 1.8004842 0.8767102 0.91542495 0.4385548 -1.0298410 0.11585417 0.15330000 0.07000000 -0.08330000 8.967952e-01 1.687445e-09 FALSE TRUE
ENST00000449089 ENSG00000187239 HEK293_OSMI2_2hA HEK293_TMG_2hB FNBP1 protein_coding protein_coding 12.06569 11.83586 12.40044 0.8263673 0.2063067 0.06717167 1.5036376 0.8819978 2.2021128 0.06738893 0.0540490 1.3103129 0.12310833 0.07446667 0.17760000 0.10313333 9.950662e-07 1.687445e-09 FALSE TRUE
MSTRG.33515.5 ENSG00000187239 HEK293_OSMI2_2hA HEK293_TMG_2hB FNBP1 protein_coding   12.06569 11.83586 12.40044 0.8263673 0.2063067 0.06717167 0.7166887 0.4128330 0.5973571 0.17839359 0.3080953 0.5224570 0.05824167 0.03363333 0.04770000 0.01406667 1.000000e+00 1.687445e-09 FALSE TRUE
MSTRG.33515.9 ENSG00000187239 HEK293_OSMI2_2hA HEK293_TMG_2hB FNBP1 protein_coding   12.06569 11.83586 12.40044 0.8263673 0.2063067 0.06717167 0.2432037 0.0000000 0.8467335 0.00000000 0.1753239 6.4207746 0.01930833 0.00000000 0.06863333 0.06863333 1.687445e-09 1.687445e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000187239 E001 712.5198128 0.0056303662 2.832719e-16 1.152599e-14 9 129887187 129889128 1942 - 2.664 2.967 1.010
ENSG00000187239 E002 282.4864904 0.0002205766 1.859566e-02 4.844527e-02 9 129889129 129890269 1141 - 2.388 2.495 0.356
ENSG00000187239 E003 21.8717892 0.0009033294 5.177301e-01 6.520657e-01 9 129890270 129890366 97 - 1.295 1.398 0.358
ENSG00000187239 E004 34.1841058 0.0006183539 4.292666e-02 9.640695e-02 9 129890367 129890546 180 - 1.442 1.620 0.608
ENSG00000187239 E005 25.2160280 0.0007892170 3.584300e-02 8.328046e-02 9 129895268 129895811 544 - 1.462 1.374 -0.302
ENSG00000187239 E006 8.1130300 0.0163428388 9.202628e-01 9.536316e-01 9 129895812 129895837 26 - 0.935 0.971 0.135
ENSG00000187239 E007 90.1091367 0.0003505845 4.223157e-01 5.654486e-01 9 129895838 129895996 159 - 1.941 1.969 0.092
ENSG00000187239 E008 48.4347879 0.0004957614 2.421543e-01 3.767444e-01 9 129899965 129899967 3 - 1.690 1.688 -0.008
ENSG00000187239 E009 56.4459249 0.0004520086 3.534658e-01 4.977073e-01 9 129899968 129899992 25 - 1.748 1.761 0.045
ENSG00000187239 E010 92.6957390 0.0003006822 1.862699e-01 3.090676e-01 9 129899993 129900101 109 - 1.963 1.972 0.030
ENSG00000187239 E011 7.7935806 0.0048727450 7.762357e-01 8.559278e-01 9 129900102 129900104 3 - 0.936 0.954 0.070
ENSG00000187239 E012 71.3047163 0.0004075214 2.921347e-01 4.330858e-01 9 129900426 129900532 107 - 1.850 1.863 0.044
ENSG00000187239 E013 31.6149376 0.0006217161 8.700730e-02 1.706025e-01 9 129900533 129900547 15 - 1.536 1.487 -0.168
ENSG00000187239 E014 47.2014300 0.0004834649 4.146499e-02 9.374343e-02 9 129902869 129902907 39 - 1.704 1.657 -0.160
ENSG00000187239 E015 58.3678925 0.0004177141 8.382428e-01 8.988554e-01 9 129902908 129903001 94 - 1.745 1.793 0.160
ENSG00000187239 E016 65.0641506 0.0004152516 2.628546e-01 4.006711e-01 9 129908890 129908999 110 - 1.812 1.820 0.027
ENSG00000187239 E017 2.7959276 0.0054841091 5.838634e-01 7.078934e-01 9 129915966 129915980 15 - 0.508 0.637 0.584
ENSG00000187239 E018 0.9440995 0.7265612133 7.401074e-01 8.296045e-01 9 129915981 129916243 263 - 0.354 0.224 -0.901
ENSG00000187239 E019 0.2955422 0.0293522935 9.503276e-01   9 129919019 129919242 224 - 0.120 0.125 0.068
ENSG00000187239 E020 54.2707480 0.0004671078 2.331521e-02 5.840580e-02 9 129923844 129923939 96 - 1.767 1.716 -0.172
ENSG00000187239 E021 34.4325319 0.0005956886 3.827663e-01 5.269295e-01 9 129923940 129923996 57 - 1.544 1.548 0.015
ENSG00000187239 E022 17.0173504 0.0010560499 9.474244e-01 9.709449e-01 9 129923997 129924026 30 - 1.219 1.279 0.211
ENSG00000187239 E023 84.4786482 0.0005926816 4.095586e-04 1.811065e-03 9 129924960 129925157 198 - 1.972 1.892 -0.268
ENSG00000187239 E024 78.7279841 0.0065302738 1.166280e-03 4.526515e-03 9 129927195 129927341 147 - 1.959 1.840 -0.398
ENSG00000187239 E025 93.2825678 0.0124074117 4.692612e-03 1.507599e-02 9 129929567 129929695 129 - 2.032 1.917 -0.387
ENSG00000187239 E026 93.4199627 0.0060084402 1.780973e-04 8.698790e-04 9 129957360 129957464 105 - 2.039 1.908 -0.439
ENSG00000187239 E027 75.2725401 0.0045215692 1.749477e-05 1.099427e-04 9 129958491 129958553 63 - 1.959 1.798 -0.541
ENSG00000187239 E028 0.1472490 0.0430777747 4.528426e-01   9 129978347 129978464 118 - 0.120 0.000 -8.760
ENSG00000187239 E029 103.0948375 0.0011442185 6.787304e-12 1.453249e-10 9 129978465 129978612 148 - 2.110 1.911 -0.667
ENSG00000187239 E030 60.4108549 0.0006192412 2.090739e-06 1.619645e-05 9 129979318 129979374 57 - 1.862 1.702 -0.540
ENSG00000187239 E031 61.8796366 0.0004354590 1.450379e-08 1.735206e-07 9 129994843 129994958 116 - 1.888 1.690 -0.666
ENSG00000187239 E032 29.1158409 0.0007229947 1.468986e-04 7.337066e-04 9 130042952 130043194 243 - 1.563 1.374 -0.649