ENSG00000187231

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000335289 ENSG00000187231 HEK293_OSMI2_2hA HEK293_TMG_2hB SESTD1 protein_coding nonsense_mediated_decay 11.01822 3.064058 19.56785 0.1944249 0.901246 2.671006 1.894241 1.0777660 2.956033 0.12400880 0.6717025 1.447166 0.21495833 0.35383333 0.1485000 -0.20533333 1.511899e-02 4.505726e-08 FALSE TRUE
ENST00000426988 ENSG00000187231 HEK293_OSMI2_2hA HEK293_TMG_2hB SESTD1 protein_coding nonsense_mediated_decay 11.01822 3.064058 19.56785 0.1944249 0.901246 2.671006 2.159379 0.5253196 4.658948 0.26312876 0.1985818 3.124625 0.17496250 0.16130000 0.2384000 0.07710000 7.252487e-01 4.505726e-08 FALSE TRUE
ENST00000428443 ENSG00000187231 HEK293_OSMI2_2hA HEK293_TMG_2hB SESTD1 protein_coding protein_coding 11.01822 3.064058 19.56785 0.1944249 0.901246 2.671006 1.455479 0.5146237 2.514118 0.03220647 0.1005698 2.266424 0.15363333 0.17083333 0.1285667 -0.04226667 4.409265e-01 4.505726e-08 FALSE TRUE
ENST00000446758 ENSG00000187231 HEK293_OSMI2_2hA HEK293_TMG_2hB SESTD1 protein_coding nonsense_mediated_decay 11.01822 3.064058 19.56785 0.1944249 0.901246 2.671006 2.141966 0.7856995 2.924624 0.24553204 0.5100504 1.882880 0.23229583 0.26456667 0.1518000 -0.11276667 6.160079e-01 4.505726e-08 TRUE TRUE
ENST00000486468 ENSG00000187231 HEK293_OSMI2_2hA HEK293_TMG_2hB SESTD1 protein_coding processed_transcript 11.01822 3.064058 19.56785 0.1944249 0.901246 2.671006 1.345881 0.0000000 2.625174 0.00000000 0.4722368 8.041755 0.08612917 0.00000000 0.1329000 0.13290000 4.505726e-08 4.505726e-08 FALSE TRUE
MSTRG.19590.6 ENSG00000187231 HEK293_OSMI2_2hA HEK293_TMG_2hB SESTD1 protein_coding   11.01822 3.064058 19.56785 0.1944249 0.901246 2.671006 1.959155 0.1606496 3.722181 0.08889888 0.1403334 4.450910 0.13235417 0.04943333 0.1914333 0.14200000 7.492107e-02 4.505726e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000187231 E001 260.0498929 0.0005520096 8.580820e-01 9.124288e-01 2 179101678 179109321 7644 - 2.328 2.337 0.030
ENSG00000187231 E002 4.1616072 0.0274416361 9.871266e-01 9.960011e-01 2 179109322 179109351 30 - 0.641 0.649 0.033
ENSG00000187231 E003 112.4485746 0.0019074433 2.358751e-14 7.341190e-13 2 179109352 179110028 677 - 1.886 2.190 1.019
ENSG00000187231 E004 48.3358367 0.0004671421 1.352724e-02 3.714266e-02 2 179112724 179112845 122 - 1.570 1.717 0.500
ENSG00000187231 E005 52.8517201 0.0004893275 4.199711e-02 9.472183e-02 2 179115065 179115256 192 - 1.616 1.734 0.401
ENSG00000187231 E006 0.4439371 0.0215845920 7.012999e-01 8.005204e-01 2 179116574 179116667 94 - 0.164 0.000 -9.980
ENSG00000187231 E007 34.1810258 0.0067623195 4.644529e-01 6.041669e-01 2 179116668 179116790 123 - 1.447 1.507 0.208
ENSG00000187231 E008 36.5770558 0.0104258405 6.493866e-01 7.606732e-01 2 179117532 179117613 82 - 1.498 1.458 -0.137
ENSG00000187231 E009 28.9006396 0.0180040256 5.069785e-01 6.426025e-01 2 179121770 179121793 24 - 1.406 1.337 -0.240
ENSG00000187231 E010 51.6763694 0.0071667533 3.077985e-01 4.500420e-01 2 179121794 179121929 136 - 1.650 1.576 -0.250
ENSG00000187231 E011 21.2292657 0.0017745024 9.596014e-01 9.786214e-01 2 179123715 179123732 18 - 1.263 1.262 -0.002
ENSG00000187231 E012 32.5339270 0.0107080940 8.327520e-01 8.952174e-01 2 179123733 179123829 97 - 1.442 1.426 -0.054
ENSG00000187231 E013 55.0757180 0.0012117879 6.993670e-01 7.991437e-01 2 179124364 179124558 195 - 1.667 1.649 -0.064
ENSG00000187231 E014 0.2966881 0.0269646031 1.000000e+00   2 179132045 179132303 259 - 0.116 0.000 -9.407
ENSG00000187231 E015 42.0257131 0.0005682420 4.929672e-01 6.300544e-01 2 179132304 179132426 123 - 1.557 1.516 -0.142
ENSG00000187231 E016 0.0000000       2 179142064 179142101 38 -      
ENSG00000187231 E017 29.0461545 0.0006804348 8.823556e-01 9.286698e-01 2 179143592 179143643 52 - 1.396 1.389 -0.025
ENSG00000187231 E018 44.7528770 0.0004772057 2.364572e-01 3.700629e-01 2 179143644 179143803 160 - 1.589 1.516 -0.252
ENSG00000187231 E019 23.6192752 0.0008295118 4.141436e-02 9.365019e-02 2 179146402 179146457 56 - 1.339 1.150 -0.666
ENSG00000187231 E020 0.0000000       2 179146458 179146459 2 -      
ENSG00000187231 E021 31.0702819 0.0006576325 1.107908e-01 2.067004e-01 2 179149297 179149394 98 - 1.447 1.323 -0.428
ENSG00000187231 E022 22.4253111 0.0009663792 2.835680e-01 4.237082e-01 2 179151278 179151322 45 - 1.304 1.210 -0.333
ENSG00000187231 E023 18.7425744 0.0060507478 4.557715e-01 5.962692e-01 2 179151323 179151331 9 - 1.225 1.150 -0.265
ENSG00000187231 E024 30.0506139 0.0010528156 1.270090e-01 2.299739e-01 2 179151332 179151391 60 - 1.430 1.309 -0.420
ENSG00000187231 E025 0.0000000       2 179162483 179162511 29 -      
ENSG00000187231 E026 42.5490409 0.0005527186 8.149178e-03 2.415968e-02 2 179172120 179172233 114 - 1.586 1.401 -0.634
ENSG00000187231 E027 0.4439371 0.0215845920 7.012999e-01 8.005204e-01 2 179174406 179174458 53 - 0.164 0.000 -9.980
ENSG00000187231 E028 37.2441899 0.0006145936 1.385353e-02 3.789358e-02 2 179176448 179176538 91 - 1.533 1.351 -0.628
ENSG00000187231 E029 29.8363818 0.0006635514 1.093350e-02 3.100137e-02 2 179183080 179183188 109 - 1.442 1.228 -0.746
ENSG00000187231 E030 16.9297196 0.0011546057 4.847828e-02 1.064696e-01 2 179191787 179191866 80 - 1.213 0.999 -0.771
ENSG00000187231 E031 0.0000000       2 179263977 179264117 141 -      
ENSG00000187231 E032 0.1515154 0.0434245421 1.000000e+00   2 179264118 179264498 381 - 0.062 0.000 -8.425
ENSG00000187231 E033 13.0335529 0.0014098163 6.740575e-03 2.054975e-02 2 179264499 179264832 334 - 1.122 0.766 -1.341