ENSG00000187210

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376730 ENSG00000187210 HEK293_OSMI2_2hA HEK293_TMG_2hB GCNT1 protein_coding protein_coding 1.520769 0.6712466 2.196779 0.02198287 0.09699083 1.695693 0.4758351 0.4343636 0.5577556 0.1450696 0.1242543 0.3535293 0.3752042 0.6613333 0.2529333 -0.4084 0.237088833 0.002660292 FALSE TRUE
ENST00000444201 ENSG00000187210 HEK293_OSMI2_2hA HEK293_TMG_2hB GCNT1 protein_coding protein_coding 1.520769 0.6712466 2.196779 0.02198287 0.09699083 1.695693 0.4623787 0.0000000 1.2324528 0.0000000 0.4372894 6.9570472 0.2370875 0.0000000 0.5456000 0.5456 0.002660292 0.002660292 FALSE TRUE
ENST00000480311 ENSG00000187210 HEK293_OSMI2_2hA HEK293_TMG_2hB GCNT1 protein_coding processed_transcript 1.520769 0.6712466 2.196779 0.02198287 0.09699083 1.695693 0.5554881 0.2132165 0.3828084 0.1767620 0.3828084 0.8153818 0.3657250 0.3025000 0.1911000 -0.1114 0.655430850 0.002660292 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000187210 E001 0.0000000       9 76419850 76419887 38 +      
ENSG00000187210 E002 0.1451727 0.043378128 1.000000000   9 76441666 76442315 650 + 0.073 0.000 -15.896
ENSG00000187210 E003 0.2944980 0.298768472 0.803566698   9 76459152 76459181 30 + 0.135 0.000 -16.895
ENSG00000187210 E004 2.0553816 0.038630287 0.859425285 0.91331895 9 76459182 76459221 40 + 0.452 0.438 -0.072
ENSG00000187210 E005 7.8072295 0.006390657 0.315026081 0.45778326 9 76459222 76459282 61 + 0.930 0.831 -0.377
ENSG00000187210 E006 8.9822375 0.002404284 0.777167628 0.85658898 9 76459283 76459305 23 + 0.957 0.959 0.007
ENSG00000187210 E007 5.4059623 0.061652418 0.145306633 0.25527329 9 76460060 76460177 118 + 0.668 0.935 1.057
ENSG00000187210 E008 15.8768786 0.012971645 0.181912306 0.30361241 9 76500916 76501061 146 + 1.209 1.100 -0.391
ENSG00000187210 E009 0.0000000       9 76501753 76501931 179 +      
ENSG00000187210 E010 176.8674453 0.044374626 0.954274181 0.97534653 9 76502239 76507416 5178 + 2.191 2.231 0.134
ENSG00000187210 E011 0.1817044 0.040978479 0.161015356   9 76515528 76515669 142 + 0.000 0.198 18.939
ENSG00000187210 E012 0.8062992 0.105972010 0.003087282 0.01052239 9 76516514 76516776 263 + 0.000 0.525 20.962
ENSG00000187210 E013 0.4031496 0.026405244 0.037171631 0.08579814 9 76527816 76527895 80 + 0.000 0.334 19.942
ENSG00000187210 E014 0.1817044 0.040978479 0.161015356   9 76564378 76564612 235 + 0.000 0.198 18.939
ENSG00000187210 E015 0.0000000       9 76565689 76565815 127 +      
ENSG00000187210 E016 0.0000000       9 76605850 76605991 142 +      
ENSG00000187210 E017 0.0000000       9 76609249 76609342 94 +      
ENSG00000187210 E018 0.0000000       9 76631397 76631495 99 +      
ENSG00000187210 E019 0.0000000       9 76642194 76642286 93 +      
ENSG00000187210 E020 0.1451727 0.043378128 1.000000000   9 76644718 76644979 262 + 0.073 0.000 -15.895
ENSG00000187210 E021 0.4375944 0.024201366 0.415374667 0.55876933 9 76649953 76651203 1251 + 0.190 0.000 -17.480